Fully automated synthesis of [18F]T807, a PET tau tracer for Alzheimer’s disease [PDF]
, 2015 The authentic standard T807 and its nitro-precursor T807P as well as t-Boc-protected T807P precursor for radiolabeling were synthesized from (4-bromophenyl)boronic acid, 3-bromo-4-nitropyridine and 3-bromo-6-nitropyridine with overall chemical yield 27 ...
Gao, Mingzhang +2 more
core +1 more source
Radiofluorination of squalenoylated drug analogues
, 2018 The conjugation of drugs with squalene derivatives has found wide spread application due to the ability of the conjugates to form nanoparticles in aqueous solutions. The conjugated drugs exhibit increased bioavailability and effectiveness against the targeted disease.
openaire +2 more sources
Automated synthesis of PET radiotracers by copperâ mediated 18Fâ fluorination of organoborons: Importance of the order of addition and competing protodeborylation [PDF]
, 2018 Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142980/1/jlcr3583_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142980/2/jlcr3583 ...
Bailey, Justin J. +7 more
core +1 more source
Peripheral ganglia in healthy rats as target structures for the evaluation of PSMA imaging agents
BMC Cancer, 2019 Background The recent implementation of PET with prostate specific membrane antigen (PSMA)-specific radiotracers into the clinical practice has resulted in the significant improvement of accuracy in the detection of prostate carcinoma (PCa).
Heike Endepols +8 more
doaj +1 more source
Synthese und trägerarme Radiofluorierung von A2A-Adenosin-Rezeptorliganden für die Positronen-Emissions-Tomographie [PDF]
, 2017 The A$_{2A}$ adenosine receptor (A$_{2A}$AR) localized in the brain has important roles in the regulationof glutamate and dopamine release. In several brain disorders like Parkinson`s disease theexpression profile of A$_{2A}$AR is altered which can be ...
Skraban, Marcel Alexander René
core
Synthesis and evaluation of 18F-labeled inhibitors for targeting mutant isocitrate dehydrogenase 1 (mIDH1) [PDF]
, 2023 PET is a fundamental imaging method used for in vivo visualization of physiological and pathophysiological processes on the molecular level. This technique relies on radiotracers, which consist of a pharmacophore addressing the biological target of ...
Cologni, Roberta
core
Journal of labelled compounds & radiopharmaceuticalsThe σ-1 receptor is a non-opioid transmembrane protein involved in various human pathologies including neurodegenerative diseases, inflammation, and cancer. The previously published ligand [18 F]FTC-146 is among the most promising tools for σ-1 molecular
Anna Marešová +8 more
semanticscholar +1 more source
Spirocyclic hypervalent iodine(III)-mediated radiofluorination of non-activated and hindered aromatics [PDF]
, 2014 Benjamin H. Rotstein +3 more
openalex +1 more source
Rapid, efficient, and economical synthesis of PET tracers in a droplet microreactor: application to O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET). [PDF]
, 2019 BackgroundConventional scale production of small batches of PET tracers (e.g. for preclinical imaging) is an inefficient use of resources. Using O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET), we demonstrate that simple microvolume radiosynthesis ...
Chen, Bao Ying +5 more
core +1 more source
Fluorination of organoboron compounds [PDF]
, 2019 Methods for the fluorination of organoboron compounds are described. This review will cover the fluorination of aromatic and aliphatic systems using both electrophilic and nucleophilc sources of fluorine.
Pattison, Graham
core +2 more sources