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Radioimmunotherapy of lymphoma
1993The development of radiolabeled monoclonal antibodies (MoAb) was a significant advance in the use of these molecules for the treatment of human neoplasms. Unlabeled murine MoAbs had proven to have modest activity against human neoplasms due to (1) the relatively poor interactions between the antibody Fc receptors and human effector cells, and (2) the ...
T M, Kuzel, S T, Rosen
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Radioimmunotherapy for lymphoma
Current Opinion in Oncology, 1999After more than a decade of unfulfilled promises, radioimmunotherapy for the treatment of non-Hodgkin's lymphoma has been demonstrated to be efficacious in the treatment of refractory disease. It is likely that in the near future, the Food and Drug Administration will approve one or more radioimmunoconjugates for clinical use.
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Selection of Radionuclides for Radioimmunotherapy
Medical Physics, 1993Selection criteria for radionuclides to be used in radioimmunotherapy are reviewed. Among the topics covered are half‐life, specific activity, type of emission, and ease of preparation. (AIP)
L F Mausner +2 more
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Review of Clinical Radioimmunotherapy
Expert Review of Anticancer Therapy, 2006Radioimmunotherapy involves a form of biologically targeted radiopharmaceutical treatment in which a radioactive isotope (typically a short-range, high-energy beta-emitter) is chemically bound to a target-specific monoclonal antibody or fragment. Thus, these radioimmunoconjugates combine the exquisite targeting specificity of the humoral immune system ...
Roger M Macklis +2 more
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Fundamentals of radioimmunotherapy
International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, 1991Design of a radioimmunotherapy trial is a complex process. This involves antibody selection, choice of radioisotope, and labeling method. Observation of the behavior of the new radiopharmaceutical involves determination of normal organ and tumor uptake, as well as residence time.
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Experimental radioimmunotherapy
Seminars in Radiation Oncology, 2000Experimental radioimmunotherapy (RIT) studies in animal models have contributed significantly to the design of clinical RIT protocols, although the results have not always been directly translated. Reviewed in this article are current areas of active research in experimental RIT to increase the therapeutic ratio that are likely to have a significant ...
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Radioimmunotherapy With Engineered Antibodies
Expert Opinion on Biological Therapy, 2004Although the advent of monoclonal antibody technology in the 1970s provided the means to specifically target radioisotopes to tumours, the initial clinical evaluations of radioimmunotherapy (RAIT) were largely unsuccessful. Over the past few decades, molecular biology techniques have advanced sufficiently to allow scientists to re-engineer antibodies ...
Gregory P Adams
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Radioimmunotherapy for Peritoneal Cancers
Immunotherapy, 2013Peritoneal carcinomatosis is the most common secondary cancerous disease to affect the peritoneal cavity, implying poor prognosis. Standard therapy consists of cytoreductive surgery in combination with adjuvant chemotherapy. To improve the therapeutic outcome, targeted therapy using radionuclides such as α-, β- and Auger emitters coupled to antibodies ...
Christof, Seidl, Markus, Essler
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Bifunctional Antibodies for Radioimmunotherapy
Hybridoma, 1995In two-step targeting technique using bifunctional antibodies, a nonradiolabeled immunoconjugate with slow uptake kinetics (several days) is initially injected, followed by a small radiolabeled hapten with fast kinetics (several hours) that binds to the bispecific immunoconjugate already taken up by the tumor target.
J F, Chatal +5 more
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Abscopal effect in radioimmunotherapy
International Immunopharmacology, 2020Abscopal effect is an interesting phenomenon in radiobiology that causes activation of immune system against cancer cells. Traditionally, this phenomenon was known as a suppressor of non-irradiated tumors or metastasis. However, it can be used as a stimulator of the immune system against primary tumor during radiotherapy.
Milad, Ashrafizadeh +5 more
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