Results 11 to 20 of about 15,914 (251)
Differentiated T Lymphocytes and Cancer Cell Mitochondrial Metabolism to Enhance Radioimmunotherapy by a Biomimetic Nanozyme System. [PDF]
Adv Sci (Weinh)T cell membrane‐coated MgCO3/Fe‐CD nanozyme loaded with TEPP‐46 (TFMP) enhances breast cancer radioimmunotherapy by reprogramming mitochondrial metabolism in T cells and tumors. It targets PD‐L1, converts H2O2 into ROS, neutralizes acidity, and releases Mg2⁺/TEPP‐46 to boost T cell activation.
Zhang H +7 more
europepmc +2 more sources
Bioactive Materials, 2023 Aggregation-Induced Emission luminogen (AIEgen) possess great potential in enhancing bioimaging-guided radiotherapeutic effects and radioimmunotherapy to improve the therapeutic effects of the tumor with good biosafety. Bacteria as a natural carrier have
Yanhong Duo +7 more
doaj +1 more source
Journal for ImmunoTherapy of Cancer, 2020 Background Radioimmunotherapy has a promising antitumor effect in hepatocellular carcinoma (HCC), depending on the regulatory effect of radiotherapy on tumor immune microenvironment.
Hui Wang +12 more
doaj +1 more source
Cell Death Discovery, 2022 Radiation resistance and unsatisfactory efficacy of radioimmunotherapy are important barriers to non-small cell lung cancer (NSCLC) treatment. The impacts of anlotinib on radiation and tumor immune microenvironment (TIME) in NSCLC remain to be resolved ...
Dong Han +5 more
doaj +1 more source
Pretargeted Alpha Therapy of Disseminated Cancer Combining Click Chemistry and Astatine-211
Pharmaceuticals, 2023 To enhance targeting efficacy in the radioimmunotherapy of disseminated cancer, several pretargeting strategies have been developed. In pretargeted radioimmunotherapy, the tumor is pretargeted with a modified monoclonal antibody that has an affinity for ...
Chiara Timperanza +4 more
doaj +1 more source
Pretargeted Radioimmunotherapy
International Journal of Radiation Oncology*Biology*Physics, 2006 This brief review covers the concept of pretargeted radioimmunotherapy and summarize the results obtained in preclinical animal models and initial phase I clinical trials. Reagents studied have been a bifunctional antibody prepared by crosslinking Fab' fragments from two antibodies with different specificity, one binding the target antigen expressed on
Ruby F, Meredith, Donald J, Buchsbaum
openaire +4 more sources
Immunostimulatory effects of radioimmunotherapy [PDF]
Journal for ImmunoTherapy of Cancer, 2022 Radiation therapy (RT) is known for its ability to kill cancer cells in an immunogenic manner. Recent preclinical data demonstrate that targeted alpha-particle therapy shares with RT the capacity to elicit immunostimulatory effects, standing out as a promising strategy to circumvent immune checkpoint inhibitor resistance in immunologically ‘cold ...
Constanzo, Julie +2 more
openaire +3 more sources
Pharmaceuticals, 2021 Background: Osteosarcoma (OS) has an overall patient survival rate of ~70% with no significant improvements in the last two decades, and novel effective treatments are needed.
Jaline Broqueza +8 more
doaj +1 more source
Immunoscintigraphy for therapy decision making and follow-up of biological therapies [PDF]
, 2016 With the availability of new biological therapies there is the need of more accurate diagnostic tools to noninvasively assess the presence of their targets.
Auletta, S. +6 more
core +2 more sources
Seminars in Radiation Oncology, 2000 Radioimmunotherapy (RIT) is a promising new therapy for the treatment of a variety of malignancies. General principles of RIT are discussed, including important considerations in the selection of monoclonal antibodies (MAb) and radionuclides for RIT.
S J, Knox, R F, Meredith
openaire +2 more sources