Results 21 to 30 of about 12,381 (205)

Preclinical efficacy of hK2 targeted [177Lu]hu11B6 for prostate cancer theranostics [PDF]

, 2019
Androgen ablating drugs increase life expectancy in men with metastatic prostate cancer, but resistance inevitably develops. In a majority of these recurrent tumors, the androgen axis is reactivated in the form of increased androgen receptor (AR ...
Beattie, Bradley J., Beattie, Kai A., Elgqvist, Jörgen, Eriksson, Sophie E., Larsson, Erik, Strand, Sven-Erik, Thorek, Daniel L. J., Timmermand, Oskar Vilhelmsson, Tran, Thuy A., Ulmert, David, Örbom, Anders   +10 more
core   +2 more sources

Pattern of antigen expression in metastases after radioimmunotherapy of a syngeneic rat colon carcinoma utilizing the BR96 antibody

Experimental Hematology & Oncology, 2012
Background Repeated administration of antibody-based therapies such as radioimmunotherapy depends on preserved antigen expression in tumor lesions. The purpose of this study was to evaluate whether the antigen expression in metastases observed after ...
Elgström Erika, Eriksson Sophie E, Ohlsson Tomas G, Tennvall Jan, Nilsson Rune   +4 more
doaj   +1 more source

Trop2 and its overexpression in cancers: regulation and clinical/therapeutic implications. [PDF]

, 2014
Trop2 is a transmembrane glycoprotein encoded by the Tacstd2 gene. It is an intracellular calcium signal transducer that is differentially expressed in many cancers. It signals cells for self-renewal, proliferation, invasion, and survival.
Bonavida, Benjamin, Shvartsur, Anna
core   +2 more sources

Chemotherapy synergizes with radioimmunotherapy targeting La autoantigen in tumors.

PLoS ONE, 2009
BackgroundTo date, inefficient delivery of therapeutic doses of radionuclides to solid tumors limits the clinical utility of radioimmunotherapy. We aim to test the therapeutic utility of Yttrium-90 ((90)Y)-radio-conjugates of a monoclonal antibody, which
Fares Al-Ejeh, Jocelyn M Darby, Michael P Brown   +2 more
doaj   +1 more source

Evaluation of response to fractionated radioimmunotherapy with 90Y-epratuzumab in non-Hodgkin’s lymphoma by 18F-fluorodeoxyglucose positron emission tomography

Haematologica, 2008
Background The study aimed to evaluate FDG-PET imaging for early prediction of response to radioimmunotherapy in patients with non-Hodgkin’s lymphoma.Design and Methods Twenty-seven patients from a large ongoing, multicenter, phase I/II trial of ...
Caroline Bodet-Milin, Françoise Kraeber-Bodéré, Benoît Dupas, Franck Morschhauser, Thomas Gastinne, Steven Le Gouill, Loïc Campion, Jean-Luc Harousseau, William A. Wegener, David M. Goldenberg, Damien Huglo   +10 more
doaj   +1 more source

Radioimmunotherapy Targeting IGF2R on Canine-Patient-Derived Osteosarcoma Tumors in Mice and Radiation Dosimetry in Canine and Pediatric Models

Pharmaceuticals, 2021
Background: Osteosarcoma (OS) has an overall patient survival rate of ~70% with no significant improvements in the last two decades, and novel effective treatments are needed.
Jaline Broqueza, Chandra B. Prabaharan, Kevin J. H. Allen, Rubin Jiao, Darrell R. Fisher, Ryan Dickinson, Valerie MacDonald-Dickinson, Maruti Uppalapati, Ekaterina Dadachova   +8 more
doaj   +1 more source

Current concepts of radioimmonotherapy for lymphoma [PDF]

Vojnosanitetski Pregled, 2015
nema
Mihailović Jasna, Ubavić Milan, Trifunović Jasna   +2 more
doaj   +1 more source

Pretargeted Alpha Therapy of Disseminated Cancer Combining Click Chemistry and Astatine-211

Pharmaceuticals, 2023
To enhance targeting efficacy in the radioimmunotherapy of disseminated cancer, several pretargeting strategies have been developed. In pretargeted radioimmunotherapy, the tumor is pretargeted with a modified monoclonal antibody that has an affinity for ...
Chiara Timperanza, Holger Jensen, Tom Bäck, Sture Lindegren, Emma Aneheim   +4 more
doaj   +1 more source

Analysis of radiation-induced cell death in head and neck squamous cell carcinoma and rat liver maintained in microfluidic devices [PDF]

, 2013
Objective The aim of this study was to investigate how head and neck squamous cell carcinoma (HNSCC) tissue biopsies maintained in a pseudo in vivo environment within a bespoke microfluidic device respond to radiation treatment.
Burcombe R, Cai L, Eriksson D, Eriksson D, Fernberg JO, Hattersley SM, Hattersley SM, Ianzini F, Jemal A, Kamotani Y, Kroemer G, Lee P, Ma H, Mamouni J, Mansilla S, Mauk MG, Mirzaie-Joniani H, Mulhall HJ, Nevill JT, Parkin DM, Reddy AC, Remmerbach TW, Skoda C, Ts’ao C, Weigum SE, Withrow KP, Young EW, Ziober BL   +27 more
core   +2 more sources

Gut microbiota: A novel and potential target for radioimmunotherapy in colorectal cancer

Frontiers in Immunology, 2023
Colorectal cancer (CRC) is one of the most common cancers, with a high mortality rate, and is a major burden on human health worldwide. Gut microbiota regulate human immunity and metabolism through producing numerous metabolites, which act as signaling ...
Hanghang Yuan, Hanghang Yuan, Ruirui Gui, Ruirui Gui, Zhicheng Wang, Fang Fang, Hongguang Zhao   +6 more
doaj   +1 more source