Results 81 to 90 of about 15,914 (251)

Review of the Management of Relapsed/Refractory Follicular Lymphoma: An Italian Perspective

Hematological Oncology, Volume 43, Issue 6, November 2025.
ABSTRACT Follicular lymphoma (FL) is an indolent disease characterized by multiple relapses and eventual refractoriness to therapy. Despite advancements in therapeutic approaches, FL treatment algorithm and management remain not well‐established, necessitating both ongoing research into novel therapeutic strategies and in stating patient journey.
Giacomo Loseto, Maria Chiara Tisi, Antonella Anastasia, Alessandro Broccoli, Ilaria Del Giudice, Caterina Patti, Benedetta Puccini, Caterina Stelitano, Vittorio Zilioli, Stefano Luminari   +9 more
wiley   +1 more source

Monoclonal Antibodies for Non-Hodgkin's Lymphoma: State of the Art and Perspectives [PDF]

, 2010
Monoclonal antibodies have been the most successful therapeutics ever brought to cancer treatment by immune technologies. The use of monoclonal antibodies in B-cell Non-Hodgkin's lymphomas (NHL) represents the greatest example of these advances, as the ...
Alessio Nencioni, Eva Moran, Federico Carbone, Franco Patrone, Giulia Motta, Michele Cea, Valeria Augusti   +6 more
core   +2 more sources

Blood-brain barrier transport kinetics of NOTA-modified proteins : the somatropin case [PDF]

, 2020
BACKGROUND: Chemical modifications such as PEG, polyamine and radiolabeling on proteins can alter their pharmacokinetic behaviour and their blood-brain barrier (BBB) transport characteristics. NOTA, i.e. 1,4,7-triazacyclononane-1,4,7-triacetic acid, is a
Bracke, Nathalie, De Spiegeleer, Bart, Janssens, Yorick, Maes, Alex, Sathekge, Mike, Tack, Liesa, Van De Wiele, Christophe, Wynendaele, Evelien   +7 more
core   +1 more source

589 Enhancement of the anti-tumor effects of CD47 blockade in solid tumors by combination with targeted radioimmunotherapy [PDF]

, 2021
Sagarika Pachhal, Emily Greer, Jesse Hwang, Qing Liang, Mary Chen, Eileen M. Geoghegan, Helen Kotanides, Dale L. Ludwig, Denis Beckford   +8 more
openalex   +1 more source

Radioimmunotherapy Dosimetry—A Review [PDF]

Acta Oncologica, 1993
Results from therapeutic trials in systemic radiation therapy with radiolabelled monoclonal antibodies are difficult to compare, because of lack of accurate dosimetry. This applies macroscopically as well as microscopically for both tumours and normal tissues.
S E, Strand, B A, Jönsson, M, Ljungberg, J, Tennvall   +3 more
openaire   +2 more sources

Cancer‐Associated Fibroblasts: Origin, Classification, Tumorigenicity, and Targeting for Cancer Therapy

MedComm, Volume 6, Issue 11, November 2025.
This review explores the multifaceted roles of cancer‐associated fibroblasts (CAFs) in tumor biology. It examines their diverse origins, dynamic activation via signaling pathways, and spatial–temporal heterogeneity, proposing an updated classification of eight distinct CAF subtypes. The review highlights CAFs' contributions to tumor growth, metastasis,
Chang Fan, Wenlong Zhu, Yuan Chen, Wanwan Zhu, Jin Ding   +4 more
wiley   +1 more source

In vitro characterization of 177Lu-radiolabelled chimeric anti-CD20 monoclonal antibody and a preliminary dosimetry study [PDF]

, 2018
Purpose: 131I- and 90Y-labelled anti-CD20 antibodies have been shown to be effective in the treatment of low-grade, B-cell non-Hodgkin's lymphoma (NHL).
Chen, Jianhua, Fani, Melpomeni, Forrer, Flavio, Lohri, Andreas, Maecke, Helmut, Moldenhauer, Gerhard, Müller-Brand, Jan, Powell, Pia   +7 more
core  

Study of the impact of tissue density heterogeneities on 3-dimensional abdominal dosimetry: comparison between dose kernel convolution and direct monte carlo methods. [PDF]

, 2012
Dose kernel convolution (DK) methods have been proposed to speed up absorbed dose calculations in molecular radionuclide therapy. Our aim was to evaluate the impact of tissue density heterogeneities (TDH) on dosimetry when using a DK method and to ...
Baechler, S., Boubaker, A., Dieudonné, A., Gardin, I., Hobbs, R.F., Le Guludec, D., Lebtahi, R., Maurel, F., Sgouros, G., Wahl, R.L.   +9 more
core   +2 more sources

A Nanomodulator Enhances Radiotherapy‐Induced In Situ Cancer Vaccine by Promoting Antigen‐Presenting of Tumor‐Associated Macrophage

Advanced Science, Volume 12, Issue 40, October 27, 2025.
A nanomodulator (Ft‐E64/Hf@Lipo) is developed, combining radiosensitizer hafnium (Hf) and the cysteine protease inhibitor E64, which cooperatively reinvigorated the antigen presentation of TAMs. Ft‐E64/Hf@Lipo sensitized‐RT generated abundant tumor neoantigens, and then E64/antigens, along with the apoptotic tumor cells, trafficked to TAMs via ...
Xiu Zhao, Mengli Li, Jun Li, Yueying Han, Yu Gong, Zhenzhong Zhang, Jinjin Shi, Cheng‐Yun Jin, Junjie Liu, Pilei Si   +9 more
wiley   +1 more source

Review of (90)Y-ibritumomab tiuxetan as first-line consolidation radio-immunotherapy for B-cell follicular non-Hodgkin’s lymphoma

Cancer Management and Research, 2009
Christos EmmanouilidesDepartment of Medical Oncology, Interbalkan Hospital, Thessaloniki, GreeceAbstract: Several studies have indicated that radioimmunotherapy is an effective and clinically relevant complementary therapeutic approach for patients with ...
Christos Emmanouilides
doaj