Results 111 to 120 of about 2,283,209 (217)

A rapid bead-based radioligand binding assay for the determination of target-binding fraction and quality control of radiopharmaceuticals. [PDF]

Nucl Med Biol, 2019
Sharma SK, Lyashchenko SK, Park HA, Pillarsetty N, Roux Y, Wu J, Poty S, Tully KM, Poirier JT, Lewis JS.   +9 more
europepmc   +1 more source

Acute Effects of Beclamide on Brain Regional Monoamine Concentrations, their Metabolites and Radioligand Binding Studies

, 1991
The effects of beclamide on regional brain monoamine levels and radioligand binding have been studied in rats. One hour oral pre-treatment with beclamide (400 mg kg−1) increased rat striatal dopamine turnover by increasing the levels of its major ...
Nicholls, P. J., P J Nicholls, Sewell, Robert David Edmund, N A Darmani, Darmani, N. A., R D E Sewell   +5 more
core   +1 more source

Synthesis and in vitro evaluation of novel compounds and discovery of a promising iodine-125 radioligand for purinergic P2X7 receptor (P2X7R)

The purinergic P2X ligand-gated ion channel 7 receptor (P2X7R) plays a critical role in various inflammatory processes and other diseases. Fast determination of compounds P2X7R binding potency and discovery of a promise PET radiotracer for imaging P2X7R ...
Qiu, Lin, Tu, Zhude, Egan, Terrance M, Perlmutter, Joel S, Wang, Jinzhi, Tewari, Manju, Rensing, Derek T   +6 more
core   +1 more source

Neuropeptide Y Receptor Binding Profiles of Endogenous Ligands in the Presence and Absence of Sodium: A Panoramic View. [PDF]

ACS Pharmacol Transl Sci
Gattor AO, Schettler F, Erl J, Brunner T, Wegener J, Koch P, Keller M.   +6 more
europepmc   +1 more source

Development of dual SST₂/SST₅ targeting radioligands through rational structural design. [PDF]

RSC Med Chem
Spinnler F, Del Pozzo L, Bohrmann L, Zanger S, Blum NK, Brendel M, Schulz S, Mansi R, Fani M.   +8 more
europepmc   +1 more source

Three Distinct Binding Modes Govern High-Affinity Ligand Interactions with Amyloid Fibrils. [PDF]

Biochemistry
Chisholm TS.
europepmc   +1 more source

Characterization of the binding of the novel compound GT-002 to GABAA receptors in the mammalian brain : Development and validation of a radioligand binding assay. A comparative study to Flumazenil

, 2017
Gamma-Amino butyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system (CNS) and inhibits the neurotransmission by targeting the ionotropic transmembrane GABAA receptor.
Emelie, Zemowska
core  

Development of pH-Sensitive β‑Adrenergic Receptor Antagonists. [PDF]

ACS Pharmacol Transl Sci
Braun T, Pröll T, Weißing N, Hübner H, Gmeiner P.   +4 more
europepmc   +1 more source

Synthesis and Characterization of Tritium-Labeled Neuropeptide Y Y₅ Receptor Ligands Derived From CGP71683A. [PDF]

Arch Pharm (Weinheim)
Schettler F, Koch P, Keller M.
europepmc   +1 more source

"Imaging Triplets on Two Wheels": 61Cu-, 64Cu-, and 68Ga-labeled Bicyclic Peptides Targeting Nectin-4 Enable High-Contrast PET Imaging of Urothelial Carcinoma and Triple-Negative Breast Cancer. [PDF]

Bioconjug Chem
Mauersberger J, Krönke T, Ullrich M, Laube M, Brandt F, Pretze M, Lohaus F, Hoberück S, Thomas C, Miederer M, Bundschuh RA, Stadlbauer S, Kopka K, Pietzsch J, Wodtke R.   +14 more
europepmc   +1 more source