Results 41 to 50 of about 30,778 (256)

Enhanced Radionuclide Therapy via the Conjugation of Pentadecanoic Acids With ²²⁵Ac- and ¹⁷⁷Lu-Labeled RGD Peptides. [PDF]

Cancer Sci
Radionuclide therapy using PD‐K(225Ac‐DOTA)‐RGD in BxPC‐3‐bearing mice. PD‐K(225Ac‐DOTA)‐RGD successfully suppressed tumor growth. ABSTRACT Improved peptide pharmacokinetics are needed to enhance the therapeutic effects of peptide‐based radionuclide therapy.
Yoshimoto M, Wada SI, Yoshii Y, Hanadate S, Inaki A, Fujii H.   +5 more
europepmc   +2 more sources

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

The application of radionuclide therapy for breast cancer

Frontiers in Nuclear Medicine
Radionuclide-mediated diagnosis and therapy have emerged as effective and low-risk approaches to treating breast cancer. Compared to traditional anatomic imaging techniques, diagnostic radionuclide-based molecular imaging systems exhibit much greater ...
Anna Musket, Anna Musket, Sandra Davern, Brianna M. Elam, Brianna M. Elam, Philip R. Musich, Jonathan P. Moorman, Jonathan P. Moorman, Yong Jiang, Yong Jiang   +9 more
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Advanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su, Guang Li, Yudong Guan, Qi Tian, Youzhi Qi, Yanqiu Zhang, Wenqian Wei, Xinxin Duan, Jiaxin Rui, Hongyan Zhu, Zengping Lin, Changchuan Xie, Zheni Xu, Yaying Wu, Xin Peng, Zhenjie Wang, Kun Chen, Xiaoyan Xin, Bing Zhang   +18 more
wiley   +1 more source

Personalized Dosimetry for Radionuclide Therapy Using Molecular Imaging Tools

Biomedicines, 2016
For treatment of systemic malignancies, when external radiation therapy is not applicable, radionuclide therapy can be an alternative. In this form of therapy, radionuclides are administered to the patient, often in a form where the radionuclide is ...
Michael Ljungberg, Katarina Sjögreen Gleisner   +1 more
doaj   +1 more source

Nuclear medicine and molecular imaging in clinical practice: yesterday, today and tomorrow

Терапевтический архив, 2021
Over the past 40 years, nuclear medicine has grown to be the largest non-invasive diagnostic and therapeutic industry in the world, playing a pivotal role in various fields and disciplines of clinical practice and contributing to improved quality of life
Vladimir B. Sergienko, Aleksei A. Ansheles   +1 more
doaj   +1 more source

It is time to move forward into the era of Theranostics

EJNMMI Research, 2018
Radionuclide therapy, which until 15 years ago included only a few approved therapies, is gaining importance in the treatment of various malignancies. The future of oncology will not be limited to surgery, chemo-, antibody therapies or external radiation;
Hojjat Ahmadzadehfar, Markus Essler
doaj   +1 more source

Production of Sm-153 With Very High Specific Activity for Targeted Radionuclide Therapy

Frontiers in Medicine, 2021
Samarium-153 (153Sm) is a highly interesting radionuclide within the field of targeted radionuclide therapy because of its favorable decay characteristics.
Michiel Van de Voorde, Charlotte Duchemin, Charlotte Duchemin, Reinhard Heinke, Reinhard Heinke, Laura Lambert, Eric Chevallay, Thomas Schneider, Miranda Van Stenis, Thomas Elias Cocolios, Thomas Cardinaels, Thomas Cardinaels, Bernard Ponsard, Maarten Ooms, Thierry Stora, Andrew R. Burgoyne   +15 more
doaj   +1 more source

Radium Speciation in Simulated Digestive Biofluids: Insights from Electrospray Ionization Mass Spectrometry and Thermodynamic Modeling

Analysis &Sensing, EarlyView.
Electrospray ionization mass spectrometry (ESI‐MS) combined with thermodynamic modeling provides the first direct characterization of radium speciation in synthetic gastrointestinal biofluids. Free Ra2+ ions predominate with minimal protein binding and negligible EDTA complexation. Crown ethers enable effective Ra complexation.
Linus Holtmann, Tim Schmalz, Tobias Weissenborn, Felix Stäger, Beate Riebe, Clemens Walther   +5 more
wiley   +1 more source