Results 41 to 50 of about 29,053 (244)
Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo
Advanced Healthcare Materials, EarlyView.This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla +16 more
wiley +1 more source
Advanced Materials, EarlyView.A multifunctional nanomedicine co‐loading of the α‐emitter 223RaCl2 within iron‐based MOFs is developed. Precisely targeted to mitochondria, it exploits the full decay spectrum to synchronize three therapeutic actions: direct α‐particle ionization, self‐powered catalytic H2O2 generation via secondary electrons, and immunogenic cell death induction ...
Xian Li +7 more
wiley +1 more source
Peptide‐Based Biomaterials as a Promising Tool for Cancer Radiotherapy
Advanced Science, EarlyView.This review provides a systematic overview of peptide‐based biomaterials in tumor radiotherapy, covering their roles as both radiosensitizers and radiopharmaceuticals. Peptide‐based radiosensitizers are generally divided into three categories: peptides as direct radiosensitizers, peptides as carriers of radiosensitizers, and targeted‐peptide‐modified ...
Qian Wang, Xinhui Chu, Jianfeng Liu
wiley +1 more source
It is time to move forward into the era of Theranostics
EJNMMI Research, 2018 Radionuclide therapy, which until 15 years ago included only a few approved therapies, is gaining importance in the treatment of various malignancies. The future of oncology will not be limited to surgery, chemo-, antibody therapies or external radiation;
Hojjat Ahmadzadehfar, Markus Essler
doaj +1 more source
Production of Sm-153 With Very High Specific Activity for Targeted Radionuclide Therapy
Frontiers in Medicine, 2021 Samarium-153 (153Sm) is a highly interesting radionuclide within the field of targeted radionuclide therapy because of its favorable decay characteristics.
Michiel Van de Voorde +15 more
doaj +1 more source
Visualization of the Spiral Ganglion Neuron in Vivo Using a Novel 177Lu Nuclear Molecule Label
Advanced Science, EarlyView.The study developed and validated a radionuclide‐labeled anti‐VGLUT1 antibody probe for the first nuclear imaging of cochlear spiral ganglion neurons (SGNs) in vivo. This approach may provide aid in screening candidates suitable for CI surgery by quantifying the number of surviving SGNs, and predicting the potential for postoperative hearing ...
Chenyang Kong +11 more
wiley +1 more source
Исследования и практика в медицине, 2015 The pain syndrome accompanying metastatic damage of bones, significantly reduces quality of patients life. In recent decades, medical practice implemented methods systemic radionuclide therapy of bone metastases using different radionuclides, which ...
A. D. Kaprin +5 more
doaj +1 more source
Targeted radionuclide therapy frontiers in theranostics [PDF]
Frontiers in Bioscience, 2017 The concept of targeted radionuclide therapy (TRT) relies on the use of injected nuclear medicine as treating agents, targeted at the cellular or molecular level. The growth of the interest in TRT was stimulated by the advances in radionuclide production and labeling as well as by the improvement in the knowledge of appropriate and specific molecular ...
Francesca Gallivanone 1 +7 more
openaire +5 more sources
Targeting Hyperglycemic Bone Pre‐Metastatic Niche for Breast Cancer Bone Metastasis Therapy
Advanced Science, EarlyView.This study reveals that breast cancer creates a hyperglycemic pre‐metastatic niche in bone prior to colonization and amplifies glucose metabolism post‐metastasis. To target this mechanism, a biomimetic enzyme‐engineered nanoplatform that disrupts tumor glycolytic pathways, proposing a therapeutic strategy to inhibit breast cancer bone metastasis by ...
Jianxin Ye +13 more
wiley +1 more source
Advanced Science, EarlyView.FM‐DEL1 and FM‐DEL2 are constructed by installing one or two sets of building blocks on a phenylalanine central scaffold. FM‐DELs are screened against markers of prostate, and renal cell carcinoma, and against an immunological target expressed on the surface of natural killer cells.
Francesca Migliorini +12 more
wiley +1 more source