Results 101 to 110 of about 22,462 (308)

Chelator impact: investigating the pharmacokinetic behavior of copper-64 labeled PD-L1 radioligands

EJNMMI Radiopharmacy and Chemistry
Background Programmed cell death ligand 1 (PD-L1) plays a critical role in the tumor microenvironment and overexpression in several solid cancers has been reported. This was associated with a downregulation of the local immune response, specifically of T-
Fabian Krutzek, Cornelius K. Donat, Sven Stadlbauer   +2 more
doaj   +1 more source

A theranostic PSMA ligand for PET imaging and retargeting of T cells expressing the universal chimeric antigen receptor UniCAR

OncoImmunology, 2019
Chimeric antigen receptor (CAR) T cells have shown impressive therapeutic potential. Due to the lack of direct control mechanisms, therapy-related adverse reactions including cytokine release- and tumor lysis syndrome can even become life-threatening. In
Claudia Arndt, Anja Feldmann, Stefanie Koristka, Martin Schäfer, Ralf Bergmann, Nicola Mitwasi, Nicole Berndt, Dominik Bachmann, Alexandra Kegler, Marc Schmitz, Edinson Puentes-Cala, Javier Andrés Soto, Gerhard Ehninger, Jens Pietzsch, Christos Liolios, Gerd Wunderlich, Jörg Kotzerke, Klaus Kopka, Michael Bachmann   +18 more
doaj   +1 more source

Folate Receptor-Positive Gynecological Cancer Cells: In Vitro and In Vivo Characterization

Pharmaceuticals, 2017
The folate receptor (FR) is expressed in a variety of gynecological cancer types. It has been widely used for tumor targeting with folic acid conjugates of diagnostic and therapeutic probes.
Klaudia Siwowska, Raffaella M. Schmid, Susan Cohrs, Roger Schibli, Cristina Müller   +4 more
doaj   +1 more source

Automatic bone marrow segmentation for precise [177Lu]Lu‐PSMA‐617 dosimetry

Medical Physics, EarlyView.
Abstract Background Bone marrow (BM) is the dominant dose‐limiting organ in [177Lu]Lu‐PSMA‐617 therapy for patients with metastasized castration resistant prostate cancer, where BM dosimetry is challenging due to segmentation. Purpose We aim to develop an automatic image‐based segmentation method on peri‐therapeutic sequential [177Lu]Lu‐PSMA‐617 images
Zhonglin Lu, Jiaxi Hu, Gefei Chen, Han Jiang, Cheng‐Ting Shih, Ali Afshar‐Oromieh, Axel Rominger, Kuangyu Shi, Greta S. P. Mok   +8 more
wiley   +1 more source

Comparison of Tumor Uptake and Kinetics of Different Radiopharmaceuticals Under Experimental Conditions [PDF]

, 1972
D. Emrich, A. von zur Mühlen, F Willgeroth, A. Lammich   +3 more
openalex   +1 more source

A novel fast strategy to calculate equieffective doses under different dose rate conditions

Medical Physics, EarlyView.
Abstract Background Radiopharmaceutical therapy (RPT) has gained notable attention for its potential in treating difficult cancers, with [177Lu]Lu‐DOTATATE being a notable example. However, the radiobiology of RPT is less understood compared to external beam radiotherapy (EBRT), and dosimetry protocols are not standardized.
Mark J. Macsuka, Roger W. Howell, Katherine A. Vallis, Daniel R. McGowan   +3 more
wiley   +1 more source

Direct determination of internal radiation dose in human blood [PDF]

arXiv, 2014
The purpose of this study is to measure the internal radiation dose using a human blood sample. In the literature, there is no process that allows the direct measurement of the internal radiation dose received by a person. The luminescence counts from a blood sample having a laboratory-injected radiation dose and the waste blood of the patient injected
arxiv  

Fast and efficient copper-mediated 18F-fluorination of arylstannanes, aryl boronic acids, and aryl boronic esters without azeotropic drying

EJNMMI Radiopharmacy and Chemistry, 2019
Background Copper-mediated radiofluorination is a straightforward method to produce a variety of [18F]fluoroarenes and [18F]fluoroheteroarenes. To minimize the number of steps in the production of 18F-labelled radiopharmaceuticals, we have developed a ...
Salla Orvokki Lahdenpohja, Noora Annika Rajala, Johan Rajander, Anna Kaarina Kirjavainen   +3 more
doaj   +1 more source

Accuracy of a whole‐body single‐photon emission computed tomography with a thallium‐bromide detector: Verification via Monte Carlo simulations

Medical Physics, EarlyView.
Abstract Background Single‐photon emission computed tomography (SPECT) devices equipped with cadmium–zinc–telluride (CZT) detectors achieve high contrast resolution because of their enhanced energy resolution. Recently, thallium bromide (TlBr) has gained attention as a detector material because of its high atomic number and density.
Toshimune Ito, Keitaro Hitomi, Michael Ljungberg, Sousei Kawasaki, Yuka Katayama, Akane Kato, Hirotatsu Tsuchikame, Kentaro Suzuki, Kyosuke Miyazaki, Ritsushi Mogi   +9 more
wiley   +1 more source

Optical surface information‐based respiratory phase‐sorting and motion‐incorporated reconstruction for SPECT imaging

Medical Physics, EarlyView.
Abstract Background Respiratory motion during the single photon emission computed tomography (SPECT) acquisition can cause blurring artifacts in the reconstructed images, leading to inaccurate estimates for activity and absorbed doses. Purpose To address the impact of respiratory motion, we utilized a new optical surface imaging (OSI) system to extract
Chenguang Li, Lucas A. Polson, Xuzhou Wu, Yibao Zhang, Carlos Uribe, Arman Rahmim   +5 more
wiley   +1 more source