Results 11 to 20 of about 16,460 (187)

Simultaneous Visualization of ¹⁶¹Tb- and ¹⁷⁷Lu-Labeled Somatostatin Analogues Using Dual-Isotope SPECT Imaging

Pharmaceutics, 2021
The decay of terbium-161 results in the emission of β¯-particles as well as conversion and Auger electrons, which makes terbium-161 interesting for therapeutic purposes.
Francesca Borgna, Patrick Barritt, Pascal V. Grundler, Zeynep Talip, Susan Cohrs, Jan Rijn Zeevaart, Ulli Köster, Roger Schibli, Nicholas P. van der Meulen, Cristina Müller   +9 more
doaj   +1 more source

Radiopharmaceutical Therapy [PDF]

Health Physics, 2019
Abstract Radiopharmaceutical therapy involves the use of radionuclides that are either conjugated to tumor-targeting agents (e.g., nanoscale constructs, antibodies, peptides, and small molecules) or that concentrate in tumors through natural physiological mechanisms that occur predominantly in neoplastic cells.
openaire   +2 more sources

The Use of Low Ammonia Concentration in the Radiochemical Purity Test of [153Sm]Sm-EDTMP by Using the Thin Layer Chromatography Method [PDF]

Journal of Pure and Applied Chemistry Research, 2021
Radiochemical purity testing of [153Sm]Sm-EDTMP usually uses the Thin Layer Chromatography method. The mobile phase used is a mixture of 25% ammonia and water. However, the lowest ratio of 25% ammonia in the mobile phase is unknown.
Amal Rezka Putra, Khoirunnisa Fauziah Asyikin, Robertus Dwi Hendarto, Agus Ariyanto, Enny Lestari, Sumandi Juliyanto, Ahsanal Fikri   +6 more
doaj  

Improved accuracy of S-value-based dosimetry: a guide to transition from Cristy–Eckerman to ICRP adult phantoms

EJNMMI Physics, 2022
Background In 2016, the International Commission on Radiological Protection (ICRP) published the results of Monte Carlo simulations performed using updated and anatomically realistic voxelized phantoms. The resulting specific absorbed fractions are based
Shalini Subramanian, Bin He, Eric Frey, Derek W. Jokisch, Wesley Bolch, George Sgouros   +5 more
doaj   +1 more source

Leveraging National Cancer Institute Programmatic Collaboration for Single Radiopharmaceutical Drug Master Files

Frontiers in Oncology, 2019
Targeted radiopharmaceutical conjugates intended for therapeutic use often are made of three key components, a decaying radionuclide, a chemical chelator/linker, and a targeted molecular entity.
Charles A. Kunos, Jacek Capala, Susan Percy Ivy   +2 more
doaj   +1 more source

Development of Antioxidant COX-2 Inhibitors as Radioprotective Agents for Radiation Therapy—A Hypothesis-Driven Review

Antioxidants, 2016
Radiation therapy (RT) evolved to be a primary treatment modality for cancer patients. Unfortunately, the cure or relief of symptoms is still accompanied by radiation-induced side effects with severe acute and late pathophysiological consequences ...
Markus Laube, Torsten Kniess, Jens Pietzsch   +2 more
doaj   +1 more source

Adjuvant Drug-Assisted Bone Healing: Advances and Challenges in Drug Delivery Approaches

Pharmaceutics, 2020
Bone defects of critical size after compound fractures, infections, or tumor resections are a challenge in treatment. Particularly, this applies to bone defects in patients with impaired bone healing due to frequently occurring metabolic diseases (above ...
Rebecca Rothe, Sandra Hauser, Christin Neuber, Markus Laube, Sabine Schulze, Stefan Rammelt, Jens Pietzsch   +6 more
doaj   +1 more source

A tool for nuclear imaging of the SARS-CoV-2 entry receptor: molecular model and preclinical development of ACE2-selective radiopeptides

EJNMMI Research, 2023
Purpose The angiotensin converting enzyme-2 (ACE2)—entry receptor of SARS-CoV-2—and its homologue, the angiotensin-converting enzyme (ACE), play a pivotal role in maintaining cardiovascular homeostasis.
Darja Beyer, Christian Vaccarin, Xavier Deupi, Ana Katrina Mapanao, Susan Cohrs, Fan Sozzi-Guo, Pascal V. Grundler, Nicholas P. van der Meulen, Jinling Wang, Matthias Tanriver, Jeffrey W. Bode, Roger Schibli, Cristina Müller   +12 more
doaj   +1 more source

Immunotheranostic target modules for imaging and navigation of UniCAR T-cells to strike FAP-expressing cells and the tumor microenvironment

Journal of Experimental & Clinical Cancer Research, 2023
Background Chimeric antigen receptor (CAR) T-cells are a promising approach in cancer immunotherapy, particularly for treating hematologic malignancies.
Liliana R. Loureiro, Lydia Hoffmann, Christin Neuber, Luise Rupp, Claudia Arndt, Alexandra Kegler, Manja Kubeil, Christoph E. Hagemeyer, Holger Stephan, Marc Schmitz, Anja Feldmann, Michael Bachmann   +11 more
doaj   +1 more source

Synthesis and Cyclooxygenase Inhibition of Sulfonamide-Substituted (Dihydro)Pyrrolo[3,2,1-hi]indoles and Their Potential Prodrugs

Molecules, 2019
Non-invasive imaging of cyclooxygenase-2 (COX-2) by radiolabeled ligands is attractive for the diagnosis of cancer, and novel highly affine leads with optimized pharmacokinetic profile are of great interest for future developments.
Markus Laube, Cemena Gassner, Torsten Kniess, Jens Pietzsch   +3 more
doaj   +1 more source