Results 31 to 40 of about 16,901 (99)

Bridging from Brain to Tumor Imaging: (S)-(−)- and (R)-(+)-[18F]Fluspidine for Investigation of Sigma-1 Receptors in Tumor-Bearing Mice

Molecules, 2018
Sigma-1 receptors (Sig1R) are highly expressed in various human cancer cells and hence imaging of this target with positron emission tomography (PET) can contribute to a better understanding of tumor pathophysiology and support the development of ...
Mathias Kranz, Ralf Bergmann, Torsten Kniess, Birgit Belter, Christin Neuber, Zhengxin Cai, Gang Deng, Steffen Fischer, Jiangbing Zhou, Yiyun Huang, Peter Brust, Winnie Deuther-Conrad, Jens Pietzsch   +12 more
doaj   +1 more source

Scalability study on [133La]LaCl3 production with a focus on potential clinical applications

EJNMMI Radiopharmacy and Chemistry
Background In recent years, targeted alpha therapy has gained importance in the clinics, and in particular, the alpha-emitter 225Ac plays a fundamental role in this clinical development.
Santiago Andrés Brühlmann, Martin Walther, Magdalena Kerstin Blei, Constantin Mamat, Klaus Kopka, Robert Freudenberg, Martin Kreller   +6 more
doaj   +1 more source

It’s a match: use of the radionuclide theranostic pair 133La/225Ac for the radiopharmacological characterization of EGFR-targeted single-domain antibodies

EJNMMI Radiopharmacy and Chemistry
Background Targeted alpha therapy represents an advanced and rapidly evolving form of precision cancer treatment with increasing importance in recent years.
Johanna Trommer, Martin Ullrich, Falco Reissig, Santiago Andres Brühlmann, Anne-Kathrin Nitt-Weber, Zbynek Novy, Katarina Hajduova, Daniela Kurfurstova, Romana Hendrychova, Jan Bouchal, Milos Petrik, Christin Neuber, Wiebke Sihver, Sven Stadlbauer, Jens Pietzsch, Martin Kreller, Klaus Kopka, Constantin Mamat, Kristof Zarschler   +18 more
doaj   +1 more source

Novel immunotheranostic FAP-inhibitor target modules for imaging and elimination of FAP-positive cells by UniCAR T-cells

OncoImmunology
The fibroblast activation protein alpha (FAPα) is overexpressed in the tumor microenvironment of most solid cancers and, in some cases, in cancer cells, making it an interesting target for theranostic applications.
Hugo Boutier, Jürgen Kogler, Liliana R. Loureiro, Christin Neuber, Nicole Berndt, Claudia Arndt, Sven Stadlbauer, Holger Stephan, Anja Feldmann, Klaus Kopka, Christoph E. Hagemeyer, Michael Bachmann   +11 more
doaj   +1 more source

Determination of Radiochemical Purity of 99mTc-DTPA Using One-System Method of Paper Chromatography [PDF]

Journal of Pure and Applied Chemistry Research, 2019
The more efficient and effective quality control techniques for 99mTc-DTPA are needed because 99mTc has a short half-life of around 6.0 hours. We have succeeded in developing a one-system of TLC for radiochemical purity testing system that is faster and ...
Maskur Maskur, Enny Lestari, Amal Rezka Putra, Dede Kurniasih, Endang Sarmini, Yayan Tahyan, Adang Hardi Gunawan, Arni Aries   +7 more
doaj  

Synthesis of Nano-α-Al2O3 for 99Mo Adsorbent

Atom Indonesia, 2018
The fission-product 99Mo, having a high specific activity, is commonly used in alumina-based 99Mo/99mTc generator. Due to the limitation on the use of fission-product 99Mo, an alternative route for 99Mo production, namely activation of natural molybdenum
K Kadarisman, S Sriyono, A Abidin, E. Lestari, M Marlina, I. Saptiama, H. Setiawan   +6 more
doaj   +1 more source

Preparation and Characterization of Zirconia Nanomaterial as a Molybdenum-99 Adsorbent

Atom Indonesia, 2017
The present study deals with the synthesis and characterization of ZrO2 nanomaterial which can be used as an adsorbent for Molybdenum-99 (99Mo). The adsorbent can potentially be utilized as the material for 99Mo/99mTc generator column.
M Marlina, E. Sarmini, H Herlina, S Sriyono, I. Saptiama, H. Setiawan, K Kadarisman   +6 more
doaj   +1 more source

Structure–activity relationship of 18F-labeled PD-L1-targeting small molecule ligands: impact of radiolabeling strategy on affinity and in vivo performance

EJNMMI Radiopharmacy and Chemistry
Background Immune checkpoint inhibitor therapy addressing the PD-1/PD-L1 axis is a promising approach in cancer treatment. A clinically suitable radiotracer would allow molecular imaging of the temporospatial changes in tumor PD-L1 expression. This could
Fabian Krutzek, Cornelius K. Donat, Sven Stadlbauer   +2 more
doaj   +1 more source

Evaluation of resazurin phenoxazine dye as a highly sensitive cell viability potency assay for natural killer cell‐derived extracellular vesicle‐based cancer biotherapeutics

Journal of Extracellular Biology
Natural killer cell‐derived extracellular vesicles (NK‐EVs) are candidate biotherapeutics against various cancers. However, standardised potency assays are necessary for a reliable assessment of NK‐EVs' cytotoxicity.
Frederic St‐Denis‐Bissonnette, Shirley Qiu, Sarah E. Cummings, Melanie Kirkby, Yohannes Haile, Sarah Wassmer, Gauri Muradia, Jelica Mehic, Andrew Stalker, Amit Shrestha, Michele Ardolino, Seung‐Hwan Lee, Dylan Burger, Lisheng Wang, Jessie R. Lavoie   +14 more
doaj   +1 more source

Radiopharmaceutical transport in solid tumors via a 3-dimensional image-based spatiotemporal model

npj Systems Biology and Applications
Lutetium-177 prostate-specific membrane antigen (177Lu-PSMA)-targeted radiopharmaceutical therapy is a clinically approved treatment for patients with metastatic castration-resistant prostate cancer (mCRPC).
Anahita Piranfar, Farshad Moradi Kashkooli, Wenbo Zhan, Ajay Bhandari, Babak Saboury, Arman Rahmim, M. Soltani   +6 more
doaj   +1 more source