Results 11 to 20 of about 26,238 (200)

Radiolabeled Silicon-Rhodamines as Bimodal PET/SPECT-NIR Imaging Agents

Pharmaceuticals, 2021
Radiolabeled fluorescent dyes are decisive for bimodal imaging as well as highly in demand for nuclear- and optical imaging. Silicon-rhodamines (SiRs) show unique near-infrared (NIR) optical properties, large quantum yields and extinction coefficients as
Thines Kanagasundaram, Markus Laube, Johanna Wodtke, Carsten Sven Kramer, Sven Stadlbauer, Jens Pietzsch, Klaus Kopka   +6 more
doaj   +1 more source

Synthesis of [18F]FMISO, a hypoxia-specific imaging probe for PET, an overview from a radiochemist’s perspective

EJNMMI Radiopharmacy and Chemistry, 2023
Background [18F]fluoromisonidazole ([18F]FMISO, 1H-1-(3-[18F]fluoro-2-hydroxypropyl)-2-nitroimidazole) is a commonly used radiotracer for imaging hypoxic conditions in cells.
Torsten Kniess, Jörg Zessin, Peter Mäding, Manuela Kuchar, Oliver Kiss, Klaus Kopka   +5 more
doaj   +1 more source

CRISPR/Cas9 Mediated Knockout of Cyclooxygenase-2 Gene Inhibits Invasiveness in A2058 Melanoma Cells

Cells, 2022
The inducible isoenzyme cyclooxygenase-2 (COX-2) is an important hub in cellular signaling, which contributes to tumor progression by modulating and enhancing a pro-inflammatory tumor microenvironment, tumor growth, apoptosis resistance, angiogenesis and
Cathleen Haase-Kohn, Markus Laube, Cornelius K. Donat, Birgit Belter, Jens Pietzsch   +4 more
doaj   +1 more source

Therapy with Radiopharmaceuticals [PDF]

Acta Oncologica, 2002
In an investigation by the Swedish Cancer Society, an expert group described the present status, critical issues and future aspects and potentials for each of nine major areas of radiation therapy research. The present report deals with therapy with radiopharmaceuticals.
Jörgen, Carlsson, Eva, Forssell-Aronsson, Bengt, Glimelius, Sören, Mattsson, The, Swedish Cancer Society Investigation Group   +4 more
openaire   +2 more sources

Radiopharmaceutical Validation for Clinical Use [PDF]

, 2021
Radiopharmaceuticals are reemerging as attractive anticancer agents, but there are no universally adopted guidelines or standardized procedures for evaluating agent validity before early-phase trial implementation.
Capala, Jacek, Myint, Zin W., Howells, Rodney, Chauhan, Aman, Kunos, Charles A., El Khouli, Riham H., Bernard, Mark E.   +6 more
core   +1 more source

Exploring Nitric Oxide (NO)-Releasing Celecoxib Derivatives as Modulators of Radioresponse in Pheochromocytoma Cells

Molecules, 2022
COX-2 can be considered as a clinically relevant molecular target for adjuvant, in particular radiosensitizing treatments. In this regard, using selective COX-2 inhibitors, e.g., in combination with radiotherapy or endoradiotherapy, represents an ...
Florian Brandt, Martin Ullrich, Verena Seifert, Cathleen Haase-Kohn, Susan Richter, Torsten Kniess, Jens Pietzsch, Markus Laube   +7 more
doaj   +1 more source

Regulation of Radiopharmaceutical Products [PDF]

, 2022
The fast development of diagnostic and therapeutic radionuclide technologies requires enhanced legislative regulation of radiopharmaceuticals. The article addresses the challenge of classifying radiopharmaceuticals depending on the manufacturing ...
A. A. Trapkova, S. N. Kalmykov, V. V. Kosenko   +2 more
core   +1 more source

The Radiobiology of Radiopharmaceuticals

Seminars in Radiation Oncology, 2021
Radiopharmaceutical therapy or targeted radionuclide therapy (TRT) is a well-established class of cancer therapeutics that includes a growing number of FDA-approved drugs and a promising pipeline of experimental therapeutics. Radiobiology is fundamental to a mechanistic understanding of the therapeutic capacity of these agents and their potential ...
Zachary S, Morris, Andrew Z, Wang, Susan J, Knox   +2 more
openaire   +3 more sources

Fluorination of silyl prosthetic groups by fluorine mediated silyl ether linker cleavage: a concept study with conditions applicable in radiofluorination

EJNMMI Radiopharmacy and Chemistry, 2022
Background Positron emission tomography (PET) is a powerful tool in medical imaging, especially in combination with the PET radionuclide fluorine-18 that possesses optimal characteristics.
Carsten Sven Kramer, Luca Greiner, Klaus Kopka, Martin Schäfer   +3 more
doaj   +1 more source

Prediction of radiation dose to adult human from radiopharmaceutical manufactured by third generation bisphosphonate labeled with Rhenium

Nuclear Engineering and Technology, 2023
Introduction: The crucial step in preclinical process of radiopharmaceutical production is internal dosimetry evaluation by different ways to realize radiobiological dose-response relationships and to extract the results for clinical use.
Zahra Pourhabib, Hassan Ranjbar
doaj   +1 more source