Results 11 to 20 of about 47,032 (177)

Fluorination of silyl prosthetic groups by fluorine mediated silyl ether linker cleavage: a concept study with conditions applicable in radiofluorination

EJNMMI Radiopharmacy and Chemistry, 2022
Background Positron emission tomography (PET) is a powerful tool in medical imaging, especially in combination with the PET radionuclide fluorine-18 that possesses optimal characteristics.
Carsten Sven Kramer, Luca Greiner, Klaus Kopka, Martin Schäfer   +3 more
doaj   +1 more source

Radiopharmaceutical therapy in cancer: clinical advances and challenges

Nature reviews. Drug discovery, 2020
Radiopharmaceutical therapy (RPT) is emerging as a safe and effective targeted approach to treating many types of cancer. In RPT, radiation is systemically or locally delivered using pharmaceuticals that either bind preferentially to cancer cells or ...
G. Sgouros, L. Bodei, M. McDevitt, Jessie R. Nedrow   +3 more
semanticscholar   +1 more source

Radiopharmaceutical Treatments for Cancer Therapy, Radionuclides Characteristics, Applications, and Challenges

Molecules, 2022
Advances in the field of molecular biology have had an impact on biomedical applications, which provide greater hope for both imaging and therapeutics.
Suliman Salih, Ajnas Alkatheeri, Wijdan Alomaim, Aisyah Elliyanti   +3 more
semanticscholar   +1 more source

Theranostic digital twins for personalized radiopharmaceutical therapies: Reimagining theranostics via computational nuclear oncology

Frontiers in Oncology, 2022
This work emphasizes that patient data, including images, are not operable (clinically), but that digital twins are. Based on the former, the latter can be created.
A. Rahmim, J. Brosch-Lenz, A. Fele-Paranj, F. Yousefirizi, M. Soltani, C. Uribe, B. Saboury   +6 more
semanticscholar   +1 more source

Good practices for 68Ga radiopharmaceutical production

EJNMMI Radiopharmacy and Chemistry, 2022
Background The radiometal gallium-68 ( 68 Ga) is increasingly used in diagnostic positron emission tomography (PET), with 68 Ga-labeled radiopharmaceuticals developed as potential higher-resolution imaging alternatives to traditional 99m Tc agents.
Bryce J B Nelson, J. Andersson, F. Wuest, S. Spreckelmeyer   +3 more
semanticscholar   +1 more source

Prediction of radiation dose to adult human from radiopharmaceutical manufactured by third generation bisphosphonate labeled with Rhenium

Nuclear Engineering and Technology, 2023
Introduction: The crucial step in preclinical process of radiopharmaceutical production is internal dosimetry evaluation by different ways to realize radiobiological dose-response relationships and to extract the results for clinical use.
Zahra Pourhabib, Hassan Ranjbar
doaj   +1 more source

Dosimetry for Radiopharmaceutical Therapy: Current Practices and Commercial Resources.

Journal of Nuclear Medicine, 2021
With the ongoing dramatic growth of radiopharmaceutical therapy, research and development in internal radiation dosimetry continue to advance both at academic medical centers and in industry.
J. Capala, S. Graves, A. Scott, G. Sgouros, S. James, P. Zanzonico, B. Zimmerman   +6 more
semanticscholar   +1 more source

Artificial Intelligence and the Future of Diagnostic and Therapeutic Radiopharmaceutical Development:: In Silico Smart Molecular Design. [PDF]

PET Clinics, 2021
Novel diagnostic and therapeutic radiopharmaceuticals are increasingly becoming a central part of personalized medicine. Continued innovation in the development of new radiopharmaceuticals is key to sustained growth and advancement of precision medicine.
Bahar Ataeinia, P. Heidari
semanticscholar   +1 more source

A Primer on Radiopharmaceutical Therapy.

International Journal of Radiation Oncology, Biology, Physics, 2022
The goal of this manuscript is to serve as a primer for the United States-based radiation oncologist who may be interested in learning more about radiopharmaceutical therapy (RPT).
K. Salerno, Soumyajit Roy, Cathy Ribaudo, Teresa L. Fisher, R. Patel, E. Mena, Freddy E. Escorcia   +6 more
semanticscholar   +1 more source

Influence of Storage Temperature on Radiochemical Purity of 99mTc-Radiopharmaceuticals [PDF]

, 2018
The influence of effective room temperature on the radiochemical purity of 99mTc-radiopharmaceuticals was reported. This study was born from the observation that in the isolators used for the preparation of the 99mTc-radiopharmaceuticals the ...
Bartolomei, Mirco, Boschi, Alessandra, Cittanti, Corrado, Donatella, Farina, Doretta, Bortolotti, Elena, Govoni, Elisa, Zappaterra, Giganti, Melchiore, Luca, Lodi, Martini, Petra, Rizzo, Carlotta, Samanta, Zaccaria, Simona, Romani, Stefania, Bertelli, Uccelli, Licia   +14 more
core   +2 more sources