Results 41 to 50 of about 26,238 (200)

Adjuvant Drug-Assisted Bone Healing: Advances and Challenges in Drug Delivery Approaches

Pharmaceutics, 2020
Bone defects of critical size after compound fractures, infections, or tumor resections are a challenge in treatment. Particularly, this applies to bone defects in patients with impaired bone healing due to frequently occurring metabolic diseases (above ...
Rebecca Rothe, Sandra Hauser, Christin Neuber, Markus Laube, Sabine Schulze, Stefan Rammelt, Jens Pietzsch   +6 more
doaj   +1 more source

A tool for nuclear imaging of the SARS-CoV-2 entry receptor: molecular model and preclinical development of ACE2-selective radiopeptides

EJNMMI Research, 2023
Purpose The angiotensin converting enzyme-2 (ACE2)—entry receptor of SARS-CoV-2—and its homologue, the angiotensin-converting enzyme (ACE), play a pivotal role in maintaining cardiovascular homeostasis.
Darja Beyer, Christian Vaccarin, Xavier Deupi, Ana Katrina Mapanao, Susan Cohrs, Fan Sozzi-Guo, Pascal V. Grundler, Nicholas P. van der Meulen, Jinling Wang, Matthias Tanriver, Jeffrey W. Bode, Roger Schibli, Cristina Müller   +12 more
doaj   +1 more source

Synthesis and Cyclooxygenase Inhibition of Sulfonamide-Substituted (Dihydro)Pyrrolo[3,2,1-hi]indoles and Their Potential Prodrugs

Molecules, 2019
Non-invasive imaging of cyclooxygenase-2 (COX-2) by radiolabeled ligands is attractive for the diagnosis of cancer, and novel highly affine leads with optimized pharmacokinetic profile are of great interest for future developments.
Markus Laube, Cemena Gassner, Torsten Kniess, Jens Pietzsch   +3 more
doaj   +1 more source

A Fast and Simple Method for the Determination of TBA in 18F-Labeled Radiopharmaceuticals

, 2020
A simple color spot test for determining the presence of residual tetrabutylammonium (TBA) in various 18F-radiopharmaceuticals is described. The test can be performed in less than five minutes.
Ole Heine Kvernenes, Nils Erik Halvorsen
core   +1 more source

Pyridyl-Ala in the third position of radiolabeled somatostatin antagonists: the effect of regioisomeric substitution

EJNMMI Radiopharmacy and Chemistry
Background The radiolabeled somatostatin receptor subtype 2 (SST2) antagonists LM3 (Phe(4-Cl)1‐c(dCys2‐Tyr3‐dAph(Cbm)4‐Lys5‐Thr6‐Cys7)-dTyr8-NH2) and JR11 (Phe(4-Cl)1‐c(dCys2‐Aph(Hor)3‐dAph(Cbm)4‐Lys5‐Thr6‐Cys7)-dTyr8-NH2) are under clinical evaluation ...
Rosalba Mansi, Natalie Bertarelli, Luigi Del Pozzo, Sandra Zanger, Tais Basaco Bernabeu, Helmut Maecke, Melpomeni Fani   +6 more
doaj   +1 more source

Immunotheranostic target modules for imaging and navigation of UniCAR T-cells to strike FAP-expressing cells and the tumor microenvironment

Journal of Experimental & Clinical Cancer Research, 2023
Background Chimeric antigen receptor (CAR) T-cells are a promising approach in cancer immunotherapy, particularly for treating hematologic malignancies.
Liliana R. Loureiro, Lydia Hoffmann, Christin Neuber, Luise Rupp, Claudia Arndt, Alexandra Kegler, Manja Kubeil, Christoph E. Hagemeyer, Holger Stephan, Marc Schmitz, Anja Feldmann, Michael Bachmann   +11 more
doaj   +1 more source

Overexpression of Receptor Tyrosine Kinase EphB4 Triggers Tumor Growth and Hypoxia in A375 Melanoma Xenografts: Insights from Multitracer Small Animal Imaging Experiments

Molecules, 2018
Experimental evidence has associated receptor tyrosine kinase EphB4 with tumor angiogenesis also in malignant melanoma. Considering the limited in vivo data available, we have conducted a systematic multitracer and multimodal imaging investigation in ...
Christin Neuber, Birgit Belter, Sebastian Meister, Frank Hofheinz, Ralf Bergmann, Hans-Jürgen Pietzsch, and Jens Pietzsch   +6 more
doaj   +1 more source

Radiopharmaceuticals for treatment of adrenocortical carcinoma

, 2023
Adrenocortical carcinoma (ACC) represents a rare tumor entity with limited treatment options and usually rapid tumor progression in case of metastatic disease.
Hartrampf, Philipp E., Kosmala, Aleksander, Wiebke Schlötelburg, Stefanie Hahner, Andreas K. Buck, Schlötelburg, Wiebke, Buck, Andreas K., Hahner, Stefanie, Schirbel, Andreas, Kerstin Michalski, Andreas Schirbel, Michalski, Kerstin, Philipp E. Hartrampf, Aleksander Kosmala   +13 more
core   +1 more source

Stability of Silver Nanoparticles as Imaging Materials [PDF]

Journal of Pure and Applied Chemistry Research, 2016
Determining the stability of silver nanoparticles is a very important process. It was associated with unwanted metal charge and materials properties. Therefore, we studied to synthesis and stability of silver nanoparticles (AgNPs).
Umi Nur Sholikhah, Anung Pujiyanto, Enny Lestari, Endang Sarmini, Triani Widyaningrum, Kadarisman, Triyanto, Putri Puspitasari   +7 more
doaj   +1 more source

Preclinical evaluation of an 18F-labeled N ε-acryloyllysine piperazide for covalent targeting of transglutaminase 2

EJNMMI Radiopharmacy and Chemistry
Background Transglutaminase 2 (TGase 2) is a multifunctional protein and has a prominent role in various (patho)physiological processes. In particular, its transamidase activity, which is rather latent under physiological conditions, gains importance in ...
Robert Wodtke, Markus Laube, Sandra Hauser, Sebastian Meister, Friedrich-Alexander Ludwig, Steffen Fischer, Klaus Kopka, Jens Pietzsch, Reik Löser   +8 more
doaj   +1 more source