Results 21 to 30 of about 27,148 (204)

Annual Report 2003 - Institute of Bioinorganic and Radiopharmaceutical chemistry [PDF]

, 2004
The report gives an overview on the activities of the Institute ofBioinorganic and Radiopharmaceutical Chemistry in ...
Spies, H., Seifert, S.
core   +2 more sources

Adjuvant Drug-Assisted Bone Healing: Advances and Challenges in Drug Delivery Approaches

Pharmaceutics, 2020
Bone defects of critical size after compound fractures, infections, or tumor resections are a challenge in treatment. Particularly, this applies to bone defects in patients with impaired bone healing due to frequently occurring metabolic diseases (above ...
Rebecca Rothe, Sandra Hauser, Christin Neuber, Markus Laube, Sabine Schulze, Stefan Rammelt, Jens Pietzsch   +6 more
doaj   +1 more source

Development of Antioxidant COX-2 Inhibitors as Radioprotective Agents for Radiation Therapy—A Hypothesis-Driven Review

Antioxidants, 2016
Radiation therapy (RT) evolved to be a primary treatment modality for cancer patients. Unfortunately, the cure or relief of symptoms is still accompanied by radiation-induced side effects with severe acute and late pathophysiological consequences ...
Markus Laube, Torsten Kniess, Jens Pietzsch   +2 more
doaj   +1 more source

Radiosynthesis Standardization and Preclinical Assessment of the [68Ga]Ga-DOTA-Ubiquicidin29-41: A Translational Study Targeting Differential Diagnosis of Infectious Processes

, 2023
Human bacterial infections significantly contribute to the increase in healthcare-related burdens. This scenario drives the study of novel techniques for the early and precise diagnosis of infectious processes. Some alternatives include Nuclear Medicine-
Fábio Fernando Alves da Silva, Walter Miguel Turato, Marycel Figols de Barboza, Lilian Yuri Itaya Yamaga, Fernanda Ferreira Mendonça, Akemi Osawa, Jorge Mejia, Luciana Malavolta, Leonardo Lima Fuscaldi, Solange Amorim Nogueira, Ana Cláudia Camargo Miranda   +10 more
core   +1 more source

Synthesis and Cyclooxygenase Inhibition of Sulfonamide-Substituted (Dihydro)Pyrrolo[3,2,1-hi]indoles and Their Potential Prodrugs

Molecules, 2019
Non-invasive imaging of cyclooxygenase-2 (COX-2) by radiolabeled ligands is attractive for the diagnosis of cancer, and novel highly affine leads with optimized pharmacokinetic profile are of great interest for future developments.
Markus Laube, Cemena Gassner, Torsten Kniess, Jens Pietzsch   +3 more
doaj   +1 more source

A tool for nuclear imaging of the SARS-CoV-2 entry receptor: molecular model and preclinical development of ACE2-selective radiopeptides

EJNMMI Research, 2023
Purpose The angiotensin converting enzyme-2 (ACE2)—entry receptor of SARS-CoV-2—and its homologue, the angiotensin-converting enzyme (ACE), play a pivotal role in maintaining cardiovascular homeostasis.
Darja Beyer, Christian Vaccarin, Xavier Deupi, Ana Katrina Mapanao, Susan Cohrs, Fan Sozzi-Guo, Pascal V. Grundler, Nicholas P. van der Meulen, Jinling Wang, Matthias Tanriver, Jeffrey W. Bode, Roger Schibli, Cristina Müller   +12 more
doaj   +1 more source

Pyridyl-Ala in the third position of radiolabeled somatostatin antagonists: the effect of regioisomeric substitution

EJNMMI Radiopharmacy and Chemistry
Background The radiolabeled somatostatin receptor subtype 2 (SST2) antagonists LM3 (Phe(4-Cl)1‐c(dCys2‐Tyr3‐dAph(Cbm)4‐Lys5‐Thr6‐Cys7)-dTyr8-NH2) and JR11 (Phe(4-Cl)1‐c(dCys2‐Aph(Hor)3‐dAph(Cbm)4‐Lys5‐Thr6‐Cys7)-dTyr8-NH2) are under clinical evaluation ...
Rosalba Mansi, Natalie Bertarelli, Luigi Del Pozzo, Sandra Zanger, Tais Basaco Bernabeu, Helmut Maecke, Melpomeni Fani   +6 more
doaj   +1 more source

Overexpression of Receptor Tyrosine Kinase EphB4 Triggers Tumor Growth and Hypoxia in A375 Melanoma Xenografts: Insights from Multitracer Small Animal Imaging Experiments

Molecules, 2018
Experimental evidence has associated receptor tyrosine kinase EphB4 with tumor angiogenesis also in malignant melanoma. Considering the limited in vivo data available, we have conducted a systematic multitracer and multimodal imaging investigation in ...
Christin Neuber, Birgit Belter, Sebastian Meister, Frank Hofheinz, Ralf Bergmann, Hans-Jürgen Pietzsch, and Jens Pietzsch   +6 more
doaj   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Radiopharmaceutical Production for PET Imaging in Poland [PDF]

, 2015
At the beginning of 2000 the PET technique was not available in Poland. The structure and organization of the Radiopharmaceuticals Production and Research Centre at the Heavy Ion Laboratory, University of Warsaw is described as an example of a production
Choiński, J.
core   +1 more source