Results 21 to 30 of about 26,238 (200)

[68Ga]Ga-PSMA-11: The First FDA-Approved 68Ga-Radiopharmaceutical for PET Imaging of Prostate Cancer

, 2021
For the positron emission tomography (PET) imaging of prostate cancer, radiotracers targeting the prostate-specific membrane antigen (PSMA) are nowadays used in clinical practice. Almost 10 years after its discovery, [68Ga]Ga-PSMA-11 has been approved in
Matthias Eder, Ute Hennrich, Eder, Matthias, Hennrich, Ute   +3 more
core   +1 more source

Sulfur [¹⁸F]Fluoride Exchange Reaction Enables Rapid Access to ¹⁸F-Labeled PET Tracers

Medical Sciences Forum, 2022
Efficient 18F-fluorination procedures for the production of radiopharmaceuticals are urgently needed to satisfy the increasing demand for clinical diagnostics using positron emission tomography (PET).
Austin Craig, Jürgen Kogler, Fabian Krutzek, Florian Brandt, Markus Laube, Martin Ullrich, Cornelius Kurt Donat, Klaus Kopka, Sven Stadlbauer   +8 more
doaj   +1 more source

Binding Parameters of [¹¹C]MPC-6827, a Microtubule-Imaging PET Radiopharmaceutical in Rodents

, 2023
Impairment and/or destabilization of neuronal microtubules (MTs) resulting from hyper-phosphorylation of the tau proteins is implicated in many pathologies, including Alzheimer’s disease (AD), Parkinson’s disease and other neurological disorders ...
Naresh Damuka, Ivan Krizan, Mack Miller, Suzanne Craft, Akiva Mintz, Krishna Kumar Gollapelli, Avinash H. Bansode, Bhuvanachandra Bhoopal, Kiran Kumar Solingapuram Sai   +8 more
core   +1 more source

Versatile chimeric antigen receptor platform for controllable and combinatorial T cell therapy

OncoImmunology, 2020
Chimeric antigen receptor (CAR) T cells show remarkable therapeutic effects in some hematological malignancies. However, CAR T cells can also cause life-threatening side effects.
Anja Feldmann, Anja Hoffmann, Ralf Bergmann, Stefanie Koristka, Nicole Berndt, Claudia Arndt, Liliana Rodrigues Loureiro, Enrico Kittel-Boselli, Nicola Mitwasi, Alexandra Kegler, Chris Lamprecht, Karla Elizabeth González Soto, Michael Bachmann   +12 more
doaj   +1 more source

Radiosynthesis Standardization and Preclinical Assessment of the [68Ga]Ga-DOTA-Ubiquicidin29-41: A Translational Study Targeting Differential Diagnosis of Infectious Processes

, 2023
Human bacterial infections significantly contribute to the increase in healthcare-related burdens. This scenario drives the study of novel techniques for the early and precise diagnosis of infectious processes. Some alternatives include Nuclear Medicine-
Fábio Fernando Alves da Silva, Walter Miguel Turato, Marycel Figols de Barboza, Lilian Yuri Itaya Yamaga, Fernanda Ferreira Mendonça, Akemi Osawa, Jorge Mejia, Luciana Malavolta, Leonardo Lima Fuscaldi, Solange Amorim Nogueira, Ana Cláudia Camargo Miranda   +10 more
core   +1 more source

Combination of lutetium-177 labelled anti-L1CAM antibody chCE7 with the clinically relevant protein kinase inhibitor MK1775: a novel combination against human ovarian carcinoma

BMC Cancer, 2018
Background Protein kinase inhibitors (PKIs) are currently tested in clinical studies (phase I-III) as an alternative strategy against (recurrent) ovarian cancer.
Dennis Lindenblatt, Nastassja Terraneo, Giovanni Pellegrini, Susan Cohrs, Philipp René Spycher, David Vukovic, Martin Béhé, Roger Schibli, Jürgen Grünberg   +8 more
doaj   +1 more source

Radiopharmaceutical Switch Maintenance for Relapsed Ovarian Carcinoma

, 2020
Switch maintenance, or using alternative therapeutic agents that were not administered during a prior course of cancer treatment, has emerged as an active clinical research and regulatory agency-approvable path in the National Cancer Institute (NCI ...
Charles Kunos, Jacek Capala
core   +1 more source

APPLICABILITY OF BACTERIAL ENDOTOXIN TEST (BET) FOR SOME RADIOPHARMACEUTICAL STERILE KITS BY THE USE OF TACHYPLEUS AMEBOCYTE LYSATE (TAL)

Jurnal Farmasi Sains dan Komunitas, 2019
The application of bacterial endotoxin test (BET) using TAL reagent on radiopharmaceutical kits is very important to conduct. The radiopharmaceutical kits that will be tested are macro aggregated albumin (MAA), tetrofosmin and ethambutol kits.
Amal Rezka Putra, Enny Lestari, Dede Kurniasih, Karyadi Karyadi, Endang Sarmini, Arni Aries   +5 more
doaj   +1 more source

Financial Toxicity Encountered in Therapeutic Radiopharmaceutical Clinical Development for Ovarian Cancer

, 2020
Financial toxicity or the debt a cancer survivor incurs from the costs of their medical cancer care is an understudied aspect in the clinical development of experimental therapeutic agents. The United States National Cancer Institute (NCI) Cancer Therapy
Rita Abdallah, Charles A. Kunos
core   +1 more source

The Use of Low Ammonia Concentration in the Radiochemical Purity Test of [153Sm]Sm-EDTMP by Using the Thin Layer Chromatography Method [PDF]

Journal of Pure and Applied Chemistry Research, 2021
Radiochemical purity testing of [153Sm]Sm-EDTMP usually uses the Thin Layer Chromatography method. The mobile phase used is a mixture of 25% ammonia and water. However, the lowest ratio of 25% ammonia in the mobile phase is unknown.
Amal Rezka Putra, Khoirunnisa Fauziah Asyikin, Robertus Dwi Hendarto, Agus Ariyanto, Enny Lestari, Sumandi Juliyanto, Ahsanal Fikri   +6 more
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