Results 51 to 60 of about 27,148 (204)

Centrum Semiovale Perivascular Spaces Predict First Hemorrhagic Lesion in Asymptomatic Amyloid‐Positive Individuals

Annals of Neurology, EarlyView.
Objective Identification of cerebral amyloid angiopathy (CAA) before its hemorrhagic manifestations remains limited. We aimed to determine whether severe enlarged perivascular spaces in the centrum semiovale (EPVS‐CSO) identify a prehemorrhagic stage of sporadic CAA by predicting the first appearance of CAA‐related hemorrhagic lesions or incident ...
Baris Alten, Elif Gokcal, Reisa A. Sperling, Zahra Shirzadi, Jasmeer P. Chhatwal, M. Edip Gurol, Scott E. Kasner, Steven M. Greenberg, Brett L. Cucchiara   +8 more
wiley   +1 more source

Prediction of First and Recurrent Falls in Parkinson's Disease

Annals of Neurology, EarlyView.
Objective To develop and externally validate prediction models for next‐year falls in Parkinson's disease (PD), and to evaluate the incremental value of imaging and fluid biomarkers. Methods We developed models in Parkinson's Progression Markers Initiative (PPMI) to predict next‐year falls with external validation in University of Pennsylvania (UPenn ...
Joaquin A. Vizcarra, Kat Hefter, Michael Tran Duong, Ashkan Ertefaie, Umberto Tachinardi, Christopher A. Olm, Hamsanandini Radhakrishnan, Corey T. McMillan, David Irwin, Daniel Weintraub, Brian Litt, Dani S. Bassett, Andrew Siderowf, The Parkinson's Progression Markers Initiative   +13 more
wiley   +1 more source

Radiosynthesis and Preclinical Evaluation of [99mTc]Tc-Tigecycline Radiopharmaceutical to Diagnose Bacterial Infections

Background/Objectives: As a primary source of mortality and disability, bacterial infections continue to develop a severe threat to humanity. Nuclear medicine imaging (NMI) is known for its promising potential to diagnose deep-seated bacterial infections.
Mohamed Fawzy Ramadan, Hassan Ali Almubarak, Abdullah M. Alkahtani, Maha Abdullah Momenah, Asma Noureen, Muhammad Shahzad Afzal, Tauqir A. Sherazi, Syeda Marab Saleem, Meshari A. Alsuwat, Tania Jabbar, Syed Ali Raza Naqvi, Hafiza Zahra Rab Nawaz, Muhammad Babar Imran   +12 more
core   +1 more source

Cyclotron production and radiochemical purification of terbium-155 for SPECT imaging

EJNMMI Radiopharmacy and Chemistry, 2021
Background Terbium-155 [T1/2 = 5.32 d, Eγ = 87 keV (32%) 105 keV (25%)] is an interesting radionuclide suitable for single photon emission computed tomography (SPECT) imaging with potential application in the diagnosis of oncological disease.
C. Favaretto, Z. Talip, F. Borgna, P. V. Grundler, G. Dellepiane, A. Sommerhalder, H. Zhang, R. Schibli, S. Braccini, C. Müller, N. P. van der Meulen   +10 more
doaj   +1 more source

Enhanced contrast in FAP-targeting PET imaging with 61Cu-labeled FAP inhibitors: development and preclinical evaluation of novel [61Cu]Cu-Kalios PET radioligands

EJNMMI Radiopharmacy and Chemistry
Background Fibroblast activation protein (FAP)-targeting radioligands have gained attention for the ability to image multiple tumor types. Current FAP-targeting radioligands are labeled with 68Ga and 18F, but their short half-lives limit distribution ...
Jacopo Millul, Tais Basaco Bernabeu, Raghuvir H. Gaonkar, Francesco De Rose, Leila Jaafar-Thiel, Gary A. Ulaner, Rosalba Mansi, Melpomeni Fani   +7 more
doaj   +1 more source

Investigation of the Putative Relationship Between Copper Transport and the Anticancer Activity of Cisplatin in Ductal Pancreatic Adenocarcinoma

Cells
Pancreatic ductal adenocarcinoma (PDAC) is a highly heterogeneous cancer with a severe stromal reaction mediated by pancreatic stellate cells (PSCs), leading to increased resistance to chemotherapy and radiotherapy.
Alina Doctor, Jonas Schädlich, Sandra Hauser, Jens Pietzsch   +3 more
doaj   +1 more source

Production of the PET radionuclide 61Cu via the 62Ni(p,2n)61Cu nuclear reaction

EJNMMI Radiopharmacy and Chemistry
Background There are only a handful of true theranostic matched pairs, and in particular the theranostic radiocopper trio 61Cu, 64Cu and 67Cu, for diagnosis and therapy respectively, is a very attractive candidate. In fact, the alternative of two imaging
Santiago Andrés Brühlmann, Martin Walther, Klaus Kopka, Martin Kreller   +3 more
doaj   +1 more source

Designing assessment for radiopharmaceutical scientist training

, 2017
ACER is working with radiopharmaceutical scientists to develop fit-for-purpose progressive assessment practices for a new training program, as Jacob Pearce ...
Pearce, Jacob
core   +1 more source

Synthesis and preclinical evaluation of FAP-targeting radiotracers for PET and optical imaging

EJNMMI Radiopharmacy and Chemistry
Background Successful treatment of solid cancers relies on precise diagnosis, e.g. using noninvasive molecular imaging, followed by surgical removal and/or chemo/immunotherapy.
Jürgen Kogler, Cornelius K. Donat, Johanna Trommer, Klaus Kopka, Sven Stadlbauer   +4 more
doaj   +1 more source

[68Ga]Ga-DOTA-TOC: The First FDA-Approved 68Ga-Radiopharmaceutical for PET Imaging

, 2020
In the United States, [68Ga]Ga-DOTA-TOC has been approved by the Food and Drug Administration (FDA) in 2019 as the first 68Ga-radiopharmaceutical for imaging of somatostatin receptor (SSTR) positive gastroenteropancreatic neuroendocrine tumors while ...
Ute Hennrich, Martina Benešová
core   +1 more source