Results 51 to 60 of about 47,032 (177)

Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): An Emerging Tool in Radiopharmaceutical Science

Journal of the American Chemical Society
Although radioactive experiments are necessary in radiopharmaceutical drug discovery and theranostic cancer research, they are expensive, require special facilities, and face certain restrictions.
K. Klika, Jianlin Han, Marvin S Busse, Vadim A. Soloshonok, Ramin Javahershenas, F. Vanhaecke, Ata Makarem   +6 more
semanticscholar   +1 more source

Adjuvant Drug-Assisted Bone Healing: Advances and Challenges in Drug Delivery Approaches

Pharmaceutics, 2020
Bone defects of critical size after compound fractures, infections, or tumor resections are a challenge in treatment. Particularly, this applies to bone defects in patients with impaired bone healing due to frequently occurring metabolic diseases (above ...
Rebecca Rothe, Sandra Hauser, Christin Neuber, Markus Laube, Sabine Schulze, Stefan Rammelt, Jens Pietzsch   +6 more
doaj   +1 more source

Evaluation of melanin-targeted radiotherapy in combination with radiosensitizing drugs for the treatment of melanoma [PDF]

, 2014
The incidence of malignant melanoma is rising faster than that of any other cancer in the United States. An [131I]-labeled benzamide - [131I]MIP-1145 - selectively targets melanin, reduces melanoma tumor burden and increases survival in preclinical ...
Babich, John, Boyd, Marie, Hutchison, Sharon, Mairs, Robert, Rae, Colin, Tesson, Mathias   +5 more
core   +1 more source

Reimbursement Approaches for Radiopharmaceutical Dosimetry: Current Status and Future Opportunities.

Journal of Nuclear Medicine, 2021
Interest in performing dosimetry for clinical radiopharmaceutical therapy procedures has grown in recent years. Several approved therapies include dosimetry in the Food and Drug Administration-approved label instructions, and other therapies are best ...
S. Graves, A. Bageac, J. Crowley, D. Merlino   +3 more
semanticscholar   +1 more source

Synthesis and Cyclooxygenase Inhibition of Sulfonamide-Substituted (Dihydro)Pyrrolo[3,2,1-hi]indoles and Their Potential Prodrugs

Molecules, 2019
Non-invasive imaging of cyclooxygenase-2 (COX-2) by radiolabeled ligands is attractive for the diagnosis of cancer, and novel highly affine leads with optimized pharmacokinetic profile are of great interest for future developments.
Markus Laube, Cemena Gassner, Torsten Kniess, Jens Pietzsch   +3 more
doaj   +1 more source

The role of copper in disulfiram-induced toxicity and radiosensitization of cancer cells [PDF]

, 2013
<p>Disulfiram has been used for several decades in the treatment of alcoholism. It now shows promise as an anti-cancer drug and radiosensitizer. Proposed mechanisms of action include the induction of oxidative stress and inhibition of proteasome ...
Ballangrud, Børup, Cen, Cohen, Hald, Maris, Sullivan, Yu, Yuhas   +8 more
core   +1 more source

Localized radiotherapy of solid tumors using radiopharmaceutical loaded implantable system: insights from a mathematical model

Frontiers in Oncology
Introduction Computational models yield valuable insights into biological interactions not fully elucidated by experimental approaches. This study investigates an innovative spatiotemporal model for simulating the controlled release and dispersion of ...
Anahita Piranfar, M. Souri, A. Rahmim, M. Soltani   +3 more
semanticscholar   +1 more source

Radiopharmaceutical Validation for Clinical Use

Frontiers in Oncology, 2021
Radiopharmaceuticals are reemerging as attractive anticancer agents, but there are no universally adopted guidelines or standardized procedures for evaluating agent validity before early-phase trial implementation.
C. Kunos, R. Howells, A. Chauhan, Z. Myint, M. Bernard, Riham H El Khouli, J. Capala   +6 more
semanticscholar   +1 more source

Pyridyl-Ala in the third position of radiolabeled somatostatin antagonists: the effect of regioisomeric substitution

EJNMMI Radiopharmacy and Chemistry
Background The radiolabeled somatostatin receptor subtype 2 (SST2) antagonists LM3 (Phe(4-Cl)1‐c(dCys2‐Tyr3‐dAph(Cbm)4‐Lys5‐Thr6‐Cys7)-dTyr8-NH2) and JR11 (Phe(4-Cl)1‐c(dCys2‐Aph(Hor)3‐dAph(Cbm)4‐Lys5‐Thr6‐Cys7)-dTyr8-NH2) are under clinical evaluation ...
Rosalba Mansi, Natalie Bertarelli, Luigi Del Pozzo, Sandra Zanger, Tais Basaco Bernabeu, Helmut Maecke, Melpomeni Fani   +6 more
doaj   +1 more source

Immunotheranostic target modules for imaging and navigation of UniCAR T-cells to strike FAP-expressing cells and the tumor microenvironment

Journal of Experimental & Clinical Cancer Research, 2023
Background Chimeric antigen receptor (CAR) T-cells are a promising approach in cancer immunotherapy, particularly for treating hematologic malignancies.
Liliana R. Loureiro, Lydia Hoffmann, Christin Neuber, Luise Rupp, Claudia Arndt, Alexandra Kegler, Manja Kubeil, Christoph E. Hagemeyer, Holger Stephan, Marc Schmitz, Anja Feldmann, Michael Bachmann   +11 more
doaj   +1 more source