Results 71 to 80 of about 17,138 (209)

Novel immunotheranostic FAP-inhibitor target modules for imaging and elimination of FAP-positive cells by UniCAR T-cells

OncoImmunology
The fibroblast activation protein alpha (FAPα) is overexpressed in the tumor microenvironment of most solid cancers and, in some cases, in cancer cells, making it an interesting target for theranostic applications.
Hugo Boutier, Jürgen Kogler, Liliana R. Loureiro, Christin Neuber, Nicole Berndt, Claudia Arndt, Sven Stadlbauer, Holger Stephan, Anja Feldmann, Klaus Kopka, Christoph E. Hagemeyer, Michael Bachmann   +11 more
doaj   +1 more source

Dynamic SPECT Assessment of Hepatic Function in Patients With Liver Disease: A Systematic Review and Meta‐Analysis

Journal of Medical Imaging and Radiation Oncology, EarlyView.
ABSTRACT Introduction Dynamic Single Photon Emission Computed Tomography (dynSPECT) is an advanced functional imaging modality that enables estimation of temporal changes in radiopharmaceutical distribution and physiological function. While dynSPECT has been employed in several clinical applications, it has not been widely applied to liver imaging ...
Bader Aloufi, Roger Fulton, Kathy Willowson, Peter L. Kench   +3 more
wiley   +1 more source

It’s a match: use of the radionuclide theranostic pair 133La/225Ac for the radiopharmacological characterization of EGFR-targeted single-domain antibodies

EJNMMI Radiopharmacy and Chemistry
Background Targeted alpha therapy represents an advanced and rapidly evolving form of precision cancer treatment with increasing importance in recent years.
Johanna Trommer, Martin Ullrich, Falco Reissig, Santiago Andres Brühlmann, Anne-Kathrin Nitt-Weber, Zbynek Novy, Katarina Hajduova, Daniela Kurfurstova, Romana Hendrychova, Jan Bouchal, Milos Petrik, Christin Neuber, Wiebke Sihver, Sven Stadlbauer, Jens Pietzsch, Martin Kreller, Klaus Kopka, Constantin Mamat, Kristof Zarschler   +18 more
doaj   +1 more source

GMP‐compliant production, validation and dosimetry of clinical grade [18F]3‐(3‐fluoropropyl)‐2‐phenyl‐2,3‐dihydrobenzo[d]thiazole ([18F]FPBT) for oxidative stress PET imaging

British Journal of Pharmacology, EarlyView.
Background and Purpose Oxidative stress plays a critical role in the pathophysiology of various diseases, yet current methods for its non‐invasive detection remain limited. This study aimed to systematically validate a superoxide‐selective PET tracer, [18F]FPBT, for the early diagnosis and therapeutic monitoring of oxidative stress‐related conditions ...
Hua Zhang, Fangfang Sun, Chun Li, Xin Wang, Yuexuan Song, Lu Jiang, Paul Gape, Samantha Y. A. Terry, Shujun He, Ran Yan, Zhi Lu   +10 more
wiley   +1 more source

Automated GMP production and long-term experience in radiosynthesis of the SV2A tracer [11C]UCB-J

EJNMMI Radiopharmacy and Chemistry
Background Positron emission tomography (PET) is a non-invasive imaging technique that enables the quantification of specific biological and pharmacological processes in vivo.
Saara Wahlroos, Anna Krzyczmonik, Semi Helin, Johan Rajander, Olof Solin, Anna K. Kirjavainen   +5 more
doaj   +1 more source

Determination of Radiochemical Purity of 99mTc-DTPA Using One-System Method of Paper Chromatography [PDF]

Journal of Pure and Applied Chemistry Research, 2019
The more efficient and effective quality control techniques for 99mTc-DTPA are needed because 99mTc has a short half-life of around 6.0 hours. We have succeeded in developing a one-system of TLC for radiochemical purity testing system that is faster and ...
Maskur Maskur, Enny Lestari, Amal Rezka Putra, Dede Kurniasih, Endang Sarmini, Yayan Tahyan, Adang Hardi Gunawan, Arni Aries   +7 more
doaj  

Diagnosis and surgical treatment of four radiographically incomplete, articular, proximal third metatarsal bone fractures

Equine Veterinary Education, EarlyView.
Summary The objective was to describe the diagnosis, surgical repair and outcome of four radiographically incomplete, articular, proximal third metatarsal bone fractures with an uncommon, dorsomedial–plantarolateral oblique configuration and this is a retrospective analysis of four racehorses presenting for surgical treatment of this uncommon fracture ...
M. J. S. Duggan, I. Wright, A. Campos Schweitzer, F. Rossignol, E. Cillán García, W. Schofield   +5 more
wiley   +1 more source

Nanomaterial‐Mediated Radiotherapy–Immunotherapy Combinations: Breaking Immunosuppression and Revolutionizing Cancer Treatment

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
Nanomaterials integrate radiotherapy and immunotherapy by enhancing radiosensitivity, remodeling the immunosuppressive tumor microenvironment, and promoting systemic antitumor immunity. This review summarizes the latest strategies of nanomaterial‐mediated combinations (RT, immunotherapy, IRT) and highlights future directions for overcoming clinical ...
Peijie Li, Xiangqin Wang, Sisi He, Hu Ma
wiley   +1 more source

Synthesis of Nano-α-Al2O3 for 99Mo Adsorbent

Atom Indonesia, 2018
The fission-product 99Mo, having a high specific activity, is commonly used in alumina-based 99Mo/99mTc generator. Due to the limitation on the use of fission-product 99Mo, an alternative route for 99Mo production, namely activation of natural molybdenum
K Kadarisman, S Sriyono, A Abidin, E. Lestari, M Marlina, I. Saptiama, H. Setiawan   +6 more
doaj   +1 more source

Increased Binding of [18F]Nifene, a PET Imaging Probe for α4β2* Nicotinic Acetylcholinergic Receptors in Hippocampus–Subiculum of Postmortem Human Parkinson's Disease Brain

Synapse, Volume 80, Issue 5, September 2026.
[18F]Nifene, a PET imaging probe for α4β2* nicotinic acetylcholine receptors, was used to discretely measure changes in hippocampus (HP) and subiculum (SUB) of postmortem Parkinson's disease (PD) cases compared to cognitively normal (CN) cases. Significant increased [18F]nifene binding in PD was observed.
Jogeshwar Mukherjee, Fariha Karim, Allyson Ngo, Christopher Liang, Geidy E. Serrano, Thomas G. Beach   +5 more
wiley   +1 more source