Results 21 to 30 of about 34,120 (225)

Imaging glutathione depletion in the rat brain using ascorbate-derived hyperpolarized MR and PET probes. [PDF]

, 2018
Oxidative stress is a critical feature of several common neurologic disorders. The brain is well adapted to neutralize oxidative injury by maintaining a high steady-state concentration of small-molecule intracellular antioxidants including glutathione in
Carroll, Valerie N, Flavell, Robert R, Keshari, Kayvan R, Kurhanewicz, John, Mutch, Christopher A, Qin, Hecong, Sriram, Renuka, Villanueva-Meyer, Javier E, von Morze, Cornelius, Wang, Zhen Jane, Wilson, David M   +10 more
core   +1 more source

Versatile chimeric antigen receptor platform for controllable and combinatorial T cell therapy

OncoImmunology, 2020
Chimeric antigen receptor (CAR) T cells show remarkable therapeutic effects in some hematological malignancies. However, CAR T cells can also cause life-threatening side effects.
Anja Feldmann, Anja Hoffmann, Ralf Bergmann, Stefanie Koristka, Nicole Berndt, Claudia Arndt, Liliana Rodrigues Loureiro, Enrico Kittel-Boselli, Nicola Mitwasi, Alexandra Kegler, Chris Lamprecht, Karla Elizabeth González Soto, Michael Bachmann   +12 more
doaj   +1 more source

Combination of lutetium-177 labelled anti-L1CAM antibody chCE7 with the clinically relevant protein kinase inhibitor MK1775: a novel combination against human ovarian carcinoma

BMC Cancer, 2018
Background Protein kinase inhibitors (PKIs) are currently tested in clinical studies (phase I-III) as an alternative strategy against (recurrent) ovarian cancer.
Dennis Lindenblatt, Nastassja Terraneo, Giovanni Pellegrini, Susan Cohrs, Philipp René Spycher, David Vukovic, Martin Béhé, Roger Schibli, Jürgen Grünberg   +8 more
doaj   +1 more source

Aptamer-based therapeutics and their potential in radiopharmaceutical design [PDF]

, 2007
Aptamers, short, single stranded oligonucleotide entities, have been developed in the past 15 years against a plethora of targets and for a variety of applications.
Ferreira, Catia S. M., Missailidis, Sotiris   +1 more
core   +3 more sources

APPLICABILITY OF BACTERIAL ENDOTOXIN TEST (BET) FOR SOME RADIOPHARMACEUTICAL STERILE KITS BY THE USE OF TACHYPLEUS AMEBOCYTE LYSATE (TAL)

Jurnal Farmasi Sains dan Komunitas, 2019
The application of bacterial endotoxin test (BET) using TAL reagent on radiopharmaceutical kits is very important to conduct. The radiopharmaceutical kits that will be tested are macro aggregated albumin (MAA), tetrofosmin and ethambutol kits.
Amal Rezka Putra, Enny Lestari, Dede Kurniasih, Karyadi Karyadi, Endang Sarmini, Arni Aries   +5 more
doaj   +1 more source

Simultaneous Visualization of ¹⁶¹Tb- and ¹⁷⁷Lu-Labeled Somatostatin Analogues Using Dual-Isotope SPECT Imaging

Pharmaceutics, 2021
The decay of terbium-161 results in the emission of β¯-particles as well as conversion and Auger electrons, which makes terbium-161 interesting for therapeutic purposes.
Francesca Borgna, Patrick Barritt, Pascal V. Grundler, Zeynep Talip, Susan Cohrs, Jan Rijn Zeevaart, Ulli Köster, Roger Schibli, Nicholas P. van der Meulen, Cristina Müller   +9 more
doaj   +1 more source

Immunoscintigraphy for therapy decision making and follow-up of biological therapies [PDF]

, 2016
With the availability of new biological therapies there is the need of more accurate diagnostic tools to noninvasively assess the presence of their targets.
Auletta, S., Carideo, Luciano, Galli, Filippo, Lauri, Chiara, Pacilio, Massimiliano, Signore, Alberto, Valabrega, Stefano   +6 more
core   +2 more sources

Radiopharmaceutical Therapy [PDF]

Health Physics, 2019
Abstract Radiopharmaceutical therapy involves the use of radionuclides that are either conjugated to tumor-targeting agents (e.g., nanoscale constructs, antibodies, peptides, and small molecules) or that concentrate in tumors through natural physiological mechanisms that occur predominantly in neoplastic cells.
openaire   +2 more sources

Locally vascularized pelvic accessory spleen [PDF]

, 2015
Il polisplenismo e la milza accessoria sono anomalie congenite generalmente asintomatiche. Riportiamo un raro caso di polisplenismo con milza pelvica ectopica in una donna bianca di 67 anni.
DRUDI, Francesco Maria, FRANTELLIZZI, VIVIANA, Iorio, F., LIBERATORE, Mauro, MAGHELLA, FABRIZIO   +4 more
core   +1 more source

Leveraging National Cancer Institute Programmatic Collaboration for Single Radiopharmaceutical Drug Master Files

Frontiers in Oncology, 2019
Targeted radiopharmaceutical conjugates intended for therapeutic use often are made of three key components, a decaying radionuclide, a chemical chelator/linker, and a targeted molecular entity.
Charles A. Kunos, Jacek Capala, Susan Percy Ivy   +2 more
doaj   +1 more source