Results 21 to 30 of about 6,328 (205)

Neuroimaging with Radiopharmaceuticals Targeting the Glutamatergic System

CHIMIA, 2020
Radiopharmacy at ETH has worked on the development of novel PET tracers for neuro-, cardiac- and tumor imaging for many years. In this paper, our efforts on targeting the glutamatergic system of the metabotropic glutamate receptor subtype 5 (mGluR5) and ...
Linjing Mu, Stefanie D. Kramer, Hazem Ahmed, Stefan Gruber, Susanne Geistlich, Roger Schibli, Simon M. Ametamey   +6 more
doaj   +1 more source

Comparative analysis of cancer cell responses to targeted radionuclide therapy (TRT) and external beam radiotherapy (EBRT)

Journal of Hematology & Oncology, 2022
The vast majority of our knowledge regarding cancer radiobiology and the activation of radioresistance mechanisms emerged from studies using external beam radiation therapy (EBRT).
Michal Grzmil, Paul Boersema, Ashish Sharma, Alain Blanc, Stefan Imobersteg, Martin Pruschy, Paola Picotti, Roger Schibli, Martin Behe   +8 more
doaj   +1 more source

Therapeutic Response of CCKBR-Positive Tumors to Combinatory Treatment with Everolimus and the Radiolabeled Minigastrin Analogue [¹⁷⁷Lu]Lu-PP-F11N

Pharmaceutics, 2021
The inhibition of the mammalian target of rapamycin complex 1 (mTORC1) by everolimus (RAD001) was recently shown to enhance the tumor uptake of radiolabeled minigastrin.
Michal Grzmil, Stefan Imobersteg, Alain Blanc, Stephan Frank, Roger Schibli, Martin P. Béhé   +5 more
doaj   +1 more source

Albumin-Binding PSMA Radioligands: Impact of Minimal Structural Changes on the Tissue Distribution Profile

Molecules, 2020
The concept of using ibuprofen as an albumin-binding entity was recently demonstrated by the development of [177Lu]Lu-Ibu-PSMA-01. In the present study, we designed a novel ibuprofen-containing radioligand (Ibu-PSMA-02) with subtle structural changes ...
Luisa M. Deberle, Viviane J. Tschan, Francesca Borgna, Fan Sozzi-Guo, Peter Bernhardt, Roger Schibli, Cristina Müller   +6 more
doaj   +1 more source

Radiosynthesis and preclinical evaluation of [11C]SNX-ab as an Hsp90α,β isoform-selective PET probe for in vivo brain and tumour imaging

EJNMMI Radiopharmacy and Chemistry, 2023
Background The molecular chaperone, Hsp90, is a key player in the protein quality control system that maintains homeostasis under cellular stress conditions.
Romy Cools, Koen Vermeulen, Valeria Narykina, Renan C. F. Leitao, Guy Bormans   +4 more
doaj   +1 more source

Pharmaceuticals—Special Issue on Radiopharmaceutical Chemistry between Imaging and Endoradiotherapy

Pharmaceuticals, 2014
The fields of molecular biology, immunology and genetics have generated many important developments that advance the understanding of the induction and progression of oncological, cardiological and neurological diseases as well as the identification of ...
Klaus Kopka
doaj   +1 more source

Medical Imaging Graduates' Knowledge About Infection Prevention and Control in Pharmaceutical Administration Including Contrast in CT and Radiopharmaceutical in Nuclear Medicine. [PDF]

J Med Radiat Sci
This study explores infection prevention and control (IPC) knowledge and training among radiographers and nuclear medicine technologists regarding pharmaceutical administration in medical imaging, including contrast in computed tomography and radiopharmaceuticals in nuclear medicine.
Freihat R, Kench P, Lewis S, Jimenez Y.
europepmc   +2 more sources

Folate Receptor-Positive Gynecological Cancer Cells: In Vitro and In Vivo Characterization

Pharmaceuticals, 2017
The folate receptor (FR) is expressed in a variety of gynecological cancer types. It has been widely used for tumor targeting with folic acid conjugates of diagnostic and therapeutic probes.
Klaudia Siwowska, Raffaella M. Schmid, Susan Cohrs, Roger Schibli, Cristina Müller   +4 more
doaj   +1 more source

Positron Emission Tomography Imaging of Bacterial Infections With an Enterobactin Analog to Monitor Treatment Efficacy With a Catechol Antibiotic

Angewandte Chemie, EarlyView.
Synopsis. The [68Ga]GaIII‐TREN‐CAM radiochelate selectively accumulates in Gram‐negative sites of infection and noninvasively monitors treatment response a siderophore antibiotic. ABSTRACT Positron emission tomography (PET) is an emerging tool under clinical investigation for the detection of bacterial infections.
M. Andrey Joaqui‐Joaqui, Phuong Nguyen Tran, Axia Marlin, Fiona Armstrong‐Pavlik, Minhua Cao, Valérie C. Pierre, Eszter Boros   +6 more
wiley   +2 more sources

Production and characterization of no-carrier-added 161Tb as an alternative to the clinically-applied 177Lu for radionuclide therapy

EJNMMI Radiopharmacy and Chemistry, 2019
Background 161Tb is an interesting radionuclide for cancer treatment, showing similar decay characteristics and chemical behavior to clinically-employed 177Lu.
Nadezda Gracheva, Cristina Müller, Zeynep Talip, Stephan Heinitz, Ulli Köster, Jan Rijn Zeevaart, Alexander Vögele, Roger Schibli, Nicholas P. van der Meulen   +8 more
doaj   +1 more source