Results 41 to 50 of about 362 (158)

44Sc for labeling of DOTA- and NODAGA-functionalized peptides: preclinical in vitro and in vivo investigations

EJNMMI Radiopharmacy and Chemistry, 2016
Background Recently, 44Sc (T1/2 = 3.97 h, Eβ+ av = 632 keV, I = 94.3 %) has emerged as an attractive radiometal candidate for PET imaging using DOTA-functionalized biomolecules.
Katharina A. Domnanich, Cristina Müller, Renata Farkas, Raffaella M. Schmid, Bernard Ponsard, Roger Schibli, Andreas Türler, Nicholas P. van der Meulen   +7 more
doaj   +1 more source

Perivascular Spaces as Determinants of Amyloid, Tau, and Vascular Biomarker Progression

Annals of Neurology, EarlyView.
Objective Magnetic resonance imaging (MRI)‐visible enlarged perivascular spaces (PVS) are markers of cerebral small vessel disease (SVD) and aging, processes implicated in both neurodegenerative and cerebrovascular pathologies. However, longitudinal positron emission tomography (PET) studies examining PVS as a mechanism underlying Alzheimer's disease ...
Audrey Low, Jeffrey L. Gunter, Mingzhao Hu, Sheelakumari Raghavan, Scott A. Przybelski, Christopher G. Schwarz, Kejal Kantarci, Val J. Lowe, Ronald C. Petersen, Jonathan Graff‐Radford, Clifford R. Jack Jr, Prashanthi Vemuri   +11 more
wiley   +1 more source

Targeted Radiotherapeutics from 'Bench-to-Bedside'

CHIMIA, 2020
he concept of targeted radionuclide therapy (TRT) is the accurate and efficient delivery of radiation to disseminated cancer lesions while minimizing damage to healthy tissue and organs.
Cristina Müller, Martin Béhé, Susanne Geistlich, Nicholas P. van der Meulen, Roger Schibli   +4 more
doaj   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Multifactorial analysis of radiochemical purity in high-activity 177Lu-labeled theranostics: impact of precursor source, 177Lu form, and production parameters

EJNMMI Radiopharmacy and Chemistry
Background Lutetium-177 (177Lu) theranostics have revolutionized personalized cancer treatment, particularly with FDA-approved therapies like [177Lu]Lu-DOTA-TATE for neuroendocrine tumors and [177Lu]Lu-PSMA for prostate cancer.
William Hunt, Mathew Long, Usama Kamil, Sunil Kellapatha, Wayne Noonan, Peter D. Roselt, Nathan Papa, Brittany Emmerson, Michael S. Hofman, Mohammad B. Haskali   +9 more
doaj   +1 more source

Stability of Silver Nanoparticles as Imaging Materials [PDF]

Journal of Pure and Applied Chemistry Research, 2016
Determining the stability of silver nanoparticles is a very important process. It was associated with unwanted metal charge and materials properties. Therefore, we studied to synthesis and stability of silver nanoparticles (AgNPs).
Umi Nur Sholikhah, Anung Pujiyanto, Enny Lestari, Endang Sarmini, Triani Widyaningrum, Kadarisman, Triyanto, Putri Puspitasari   +7 more
doaj   +1 more source

Radiopharmaceuticals for Cancer Imaging and Therapy

Pharmaceutics, 2023
Nuclear medicine has emerged as a pivotal player in cancer patient care, revolutionizing the way cancer is detected, diagnosed, monitored, and treated [...]
Guy Bormans, Frederik Cleeren
doaj   +1 more source

Homo‐/Heterodimeric Substrates Bias the Type and Multiplicity of Hydroxamic Acid Chelators Assembled by a NIS Synthetase DesD

Chemistry – A European Journal, EarlyView.
Chemoenzymatic reactions using the siderophore synthetase DesD from Salinispora tropica and hydroxamic acid substrates (native, non‐native) with different multiplicities (monomer, dimer) and components (homo‐/heterodimer) followed different reaction trajectories, which biased the architectures of the chelator major products and indicated DesD contains ...
Callum A. Rosser, Todd E. Markham, Rachel Codd   +2 more
wiley   +1 more source

Peptide Marriages: Modular Assembly of Multi‐Agonist Therapeutics

Chemistry – A European Journal, EarlyView.
A modular polyethylene glycol (PEG) scaffold enables rapid assembly of dual peptide agonists using strain‐promoted azide–alkyne cycloaddition (SPAAC) and copper‐catalysed azide–alkyne cycloaddition (CuAAC). Glucagon‐like peptide‐1 (GLP‐1) and amylin agonists were combined with controlled valency, yielding low‐picomolar activity and receptor‐selective ...
Kristina A. Kostadinova, Jan L. Venne, Sona Krajcovicova, James Dodgson, Wouter F. J. Hogendorf, Thomas E. Nielsen, David Hymel, Hannah Bolt, Andie Collinson, Jason Day, Jefferson Revell, David R. Spring   +11 more
wiley   +1 more source

Comparison of desferrioxamine and NODAGA for the gallium-68 labeling of exendin-4

EJNMMI Radiopharmacy and Chemistry, 2019
Introduction Radiolabeled exendin-4 (Ex4) derivatives are used to target the glucagon-like peptide-1 receptor (GLP-1R) for the clinical diagnosis of insulinomas, a rare type of neuroendocrine tumor.
Simon A. M. Kaeppeli, Roger Schibli, Thomas L. Mindt, Martin Behe   +3 more
doaj   +1 more source