Results 51 to 60 of about 362 (158)

Quantitative studies in radiopharmaceutical science. Final report, January 1, 1993--December 31, 1993 [PDF]

, 1996
This report briefly summarizes published research at the University of Chicago in the area of quantitative studies in radiopharmaceutical science covering radiochemistry and PET/MRI imaging.
Cooper, M., Beck, R.N.
openaire   +2 more sources

Retro‐Hetero‐Michael Addition Strategies in Organic Synthesis

European Journal of Organic Chemistry, EarlyView.
In this review, synthetic approaches to carbo‐ and heterocyclic compounds, including natural products, published in the last 15 years (2011–2025) which have either relied upon or included a retro‐hetero‐Michael addition step at any stage are discussed.
Dina Scarpi, Ernesto G. Occhiato
wiley   +1 more source

Terbium-149 production: a focus on yield and quality improvement towards preclinical application

Scientific Reports
Terbium-149 (T1/2 = 4.1 h, Eα = 3.98 MeV (16.7%), 28 µm range in tissue) is a radionuclide with potential for targeted alpha therapy. Due to the negligible emission of α-emitting daughter nuclides, toxicity to healthy tissue may be reduced in comparison ...
C. Favaretto, P. V. Grundler, Z. Talip, U. Köster, K. Johnston, S. D. Busslinger, P. Sprung, C. C. Hillhouse, R. Eichler, R. Schibli, C. Müller, N. P. van der Meulen   +11 more
doaj   +1 more source

66Ga: A Novelty or a Valuable Preclinical Screening Tool for the Design of Targeted Radiopharmaceuticals?

Molecules, 2018
Emerging interest in extending the plasma half-life of small molecule radioligands warrants a consideration of the appropriate radionuclide for PET imaging at longer time points (>8 h). Among candidate positron-emitting radionuclides, 66Ga (t1/2 = 9.5
Alejandro Amor-Coarasa, James M. Kelly, Shashikanth Ponnala, Anastasia Nikolopoulou, Clarence Williams, John W. Babich   +5 more
doaj   +1 more source

Detecting radio- and chemoresistant cells in 3D cancer co-cultures using chromatin biomarkers

Scientific Reports, 2023
The heterogenous treatment response of tumor cells limits the effectiveness of cancer therapy. While this heterogeneity has been linked to cell-to-cell variability within the complex tumor microenvironment, a quantitative biomarker that identifies and ...
Tina Pekeč, Saradha Venkatachalapathy, Anne R. Shim, Daniel Paysan, Michal Grzmil, Roger Schibli, Martin Béhé, G. V. Shivashankar   +7 more
doaj   +1 more source

Epigenetic Dysregulation of Somatostatin Receptors (SSTR) 1–5 and Therapeutic Implications in Neuroendocrine and Non‐Neuroendocrine Malignancies

International Journal of Cancer, EarlyView.
ABSTRACT Somatostatin receptors (SSTR) mediate the antiproliferative, antisecretory, and proapoptotic effects of somatostatin and its synthetic analogs. Their surface expression on neuroendocrine tumor (NET) cells is required for somatostatin analog therapy and radiopharmaceutical therapy (RPT).
Neeraj Kumari, Pablo Hoffmann, Laura Reichl, Maximilian Schmutz, Nina Fischer, Thi Tuong Vi Dang, Fulvia Ferrazzi, Pascal Johann, Michaela Kuhlen, Constantin Lapa, Rainer Claus   +10 more
wiley   +1 more source

Radiosynthesis and evaluation of an 18F–labeled silicon containing exendin-4 peptide as a PET probe for imaging insulinoma

EJNMMI Radiopharmacy and Chemistry, 2018
Background Analogues of exendin-4 have been radiolabeled for imaging the glucagon-like peptide type 1 receptors (GLP-1R) which are overexpressed in insulinoma. The aim of this research was to synthesize an 18F–labeled silicon containing exendin-4 peptide
Lukas O. Dialer, Andreas Jodal, Roger Schibli, Simon M. Ametamey, Martin Béhé   +4 more
doaj   +1 more source

Precise activity measurements of medical radionuclides using an ionization chamber: a case study with Terbium-161

EJNMMI Physics, 2022
Background 161Tb draws an increasing interest in nuclear medicine for therapeutic applications. More than 99% of the emitted gamma and X-rays of 161Tb have an energy below 100 keV.
Frédéric Juget, Zeynep Talip, Youcef Nedjadi, M. Teresa Durán, Pascal V. Grundler, Jan Rijn Zeevaart, Nicholas P. van der Meulen, Claude Bailat   +7 more
doaj   +1 more source

Technical Assessment of Preclinical Noninvasive Imaging Methods for Endometriosis Follow‐Up in Murine Models

iRADIOLOGY, EarlyView.
This schematic rapidly illustrates the diverse imaging modalities used in preclinical endometriosis research. It highlights optical techniques, such as bioluminescence, fluorescence, and nanoparticle‐assisted imaging, alongside non optical approaches like MRI, ultrasound, and PET, which are key tools in advancing diagnostic precision and understanding ...
Peyman Palay, Tayyebeh Zamani‐Badi, Zeinab Ghezelayagh, Kiandokht Kiani   +3 more
wiley   +1 more source

Occupational burnout in nuclear medicine technologists working in Australia and New Zealand – results of a multi‐national survey

Journal of Medical Radiation Sciences, Volume 72, Issue 1, Page 25-33, March 2025.
Occupational burnout is associated with negative feelings about the workplace and is often caused by a high workload and a non‐supportive workplace. It is associated with absenteeism, high turnover of staff and decreased patient care. More than half of the New Zealand participants and three quarters of the Australian participants had moderate levels of
Melissa Shields, Daphne James, Lynne McCormack   +2 more
wiley   +1 more source