Results 31 to 40 of about 12,450 (234)

Radiosynthesis and preclinical evaluation of [11C]SNX-ab as an Hsp90α,β isoform-selective PET probe for in vivo brain and tumour imaging

EJNMMI Radiopharmacy and Chemistry, 2023
Background The molecular chaperone, Hsp90, is a key player in the protein quality control system that maintains homeostasis under cellular stress conditions.
Romy Cools, Koen Vermeulen, Valeria Narykina, Renan C. F. Leitao, Guy Bormans   +4 more
doaj   +1 more source

The suppression of DNA repair induced by PARP-1 inhibitors rucaparib and olaparib in combination with the radiopharmaceutical 131I-MIBG in noradrenaline transporter-expressing xenograft tumors [PDF]

, 2018
No abstract ...
Gaze, Mark N., Mairs, Robert J., Nile, Donna L., Nixon, Colin, Rae, Colin   +4 more
core   +1 more source

Nuclear medicine and imaging research (quantitative studies in radiopharmaceutical science) [PDF]

, 1990
This report describes three studies aimed at using radiolabeled pharmaceuticals to explore brain function and anatomy. The first section describes the chemical preparation of (F18)fluorinated benzamides (dopamine D-2 receptor tracers), (F18)fluorinated benzazepines (dopamine D-1 receptor tracers), and tissue distribution of (F18)-fluoxetine (serotonin ...
Cooper, M., Beck, R. N.
openaire   +2 more sources

Immunoscintigraphy for therapy decision making and follow-up of biological therapies [PDF]

, 2016
With the availability of new biological therapies there is the need of more accurate diagnostic tools to noninvasively assess the presence of their targets.
Auletta, S., Carideo, Luciano, Galli, Filippo, Lauri, Chiara, Pacilio, Massimiliano, Signore, Alberto, Valabrega, Stefano   +6 more
core   +2 more sources

Science research experience in the use of radiopharmaceuticals at the N.N. Petrov NMRC of Oncology [PDF]

Pharmacy Formulas, 2021
Radionuclide diagnostics and therapy with open radionuclide sources are one of the most promising and fast-growing areas ofmodern oncology. The paper presents the main achievements of the N.N. Petrov National Medical Research Center of Oncology, one of the leading departments of radionuclide diagnostics in Russia.
openaire   +1 more source

Production and characterization of no-carrier-added 161Tb as an alternative to the clinically-applied 177Lu for radionuclide therapy

EJNMMI Radiopharmacy and Chemistry, 2019
Background 161Tb is an interesting radionuclide for cancer treatment, showing similar decay characteristics and chemical behavior to clinically-employed 177Lu.
Nadezda Gracheva, Cristina Müller, Zeynep Talip, Stephan Heinitz, Ulli Köster, Jan Rijn Zeevaart, Alexander Vögele, Roger Schibli, Nicholas P. van der Meulen   +8 more
doaj   +1 more source

Imaging Active Infection in vivo Using D-Amino Acid Derived PET Radiotracers. [PDF]

, 2017
Occult bacterial infections represent a worldwide health problem. Differentiating active bacterial infection from sterile inflammation can be difficult using current imaging tools. Present clinically viable methodologies either detect morphologic changes
Blecha, Joseph E, Flavell, Robert R, Kwak, Tiffany, Mutch, Christopher A, Neumann, Kiel D, Ohliger, Michael A, Rosenberg, Oren S, Sriram, Renuka, VanBrocklin, Henry F, Villanueva-Meyer, Javier E, Wilson, David M   +10 more
core   +1 more source

Folate Receptor-Positive Gynecological Cancer Cells: In Vitro and In Vivo Characterization

Pharmaceuticals, 2017
The folate receptor (FR) is expressed in a variety of gynecological cancer types. It has been widely used for tumor targeting with folic acid conjugates of diagnostic and therapeutic probes.
Klaudia Siwowska, Raffaella M. Schmid, Susan Cohrs, Roger Schibli, Cristina Müller   +4 more
doaj   +1 more source

A Step-by-Step Guide for the Novel Radiometal Production for Medical Applications: Case Studies with ⁶⁸Ga, ⁴⁴Sc, ¹⁷⁷Lu and ¹⁶¹Tb

Molecules, 2020
The production of novel radionuclides is the first step towards the development of new effective radiopharmaceuticals, and the quality thereof directly affects the preclinical and clinical phases.
Zeynep Talip, Chiara Favaretto, Susanne Geistlich, Nicholas P. van der Meulen   +3 more
doaj   +1 more source

Radiosensitization of noradrenaline transporter-expressing tumour cells by proteasome inhibitors and the role of reactive oxygen species [PDF]

, 2013
Background The radiopharmaceutical 131I-metaiodobenzylguanidine (131I-MIBG) is used for the targeted radiotherapy of noradrenaline transporter (NAT)-expressing neuroblastoma.
Babich, J.W., Boyd, M., Mairs, R.J., Rae, C., Tesson, M.   +4 more
core   +3 more sources