Results 31 to 40 of about 7,465 (248)

Targeted Alpha Therapy: All We Need to Know about 225Ac’s Physical Characteristics and Production as a Potential Theranostic Radionuclide

, 2023
The high energy of α emitters, and the strong linear energy transfer that goes along with it, lead to very efficient cell killing through DNA damage.
Cati Raluca Stolniceanu, Vlad Ghizdovat, Irena Cristina Grierosu, Ioana Pavaleanu, Teodor Ionescu, Mihaela Moscalu, Cipriana Stefanescu, Wael Jalloul   +7 more
core   +1 more source

Albumin-Binding PSMA Radioligands: Impact of Minimal Structural Changes on the Tissue Distribution Profile

Molecules, 2020
The concept of using ibuprofen as an albumin-binding entity was recently demonstrated by the development of [177Lu]Lu-Ibu-PSMA-01. In the present study, we designed a novel ibuprofen-containing radioligand (Ibu-PSMA-02) with subtle structural changes ...
Luisa M. Deberle, Viviane J. Tschan, Francesca Borgna, Fan Sozzi-Guo, Peter Bernhardt, Roger Schibli, Cristina Müller   +6 more
doaj   +1 more source

Radiosynthesis and preclinical evaluation of [11C]SNX-ab as an Hsp90α,β isoform-selective PET probe for in vivo brain and tumour imaging

EJNMMI Radiopharmacy and Chemistry, 2023
Background The molecular chaperone, Hsp90, is a key player in the protein quality control system that maintains homeostasis under cellular stress conditions.
Romy Cools, Koen Vermeulen, Valeria Narykina, Renan C. F. Leitao, Guy Bormans   +4 more
doaj   +1 more source

Science research experience in the use of radiopharmaceuticals at the N.N. Petrov NMRC of Oncology [PDF]

Pharmacy Formulas, 2021
Radionuclide diagnostics and therapy with open radionuclide sources are one of the most promising and fast-growing areas ofmodern oncology. The paper presents the main achievements of the N.N. Petrov National Medical Research Center of Oncology, one of the leading departments of radionuclide diagnostics in Russia.
openaire   +1 more source

A Fast and Simple Method for the Determination of TBA in 18F-Labeled Radiopharmaceuticals

, 2020
A simple color spot test for determining the presence of residual tetrabutylammonium (TBA) in various 18F-radiopharmaceuticals is described. The test can be performed in less than five minutes.
Ole Heine Kvernenes, Nils Erik Halvorsen
core   +1 more source

Reactive Palladium–Ligand Complexes for 11C-Carbonylation at Ambient Pressure: A Breakthrough in Carbon-11 Chemistry

, 2023
The Pd–Xantphos-mediated 11C-carbonylation protocol (also known as the “Xantphos- method”), due to its simplistic and convenient nature, has facilitated researchers in meeting a longstanding need for preparing 11C-carbonyl-labeled ...
Lindberg, A, Dahl, Kenneth, Kenneth Dahl, Schou, Magnus, Anton Lindberg, Vasdev, Neil, Magnus Schou, Vasdev, N, Lindberg, Anton, Neil Vasdev, Dahl, K, Schou, M   +11 more
core   +1 more source

Folate Receptor-Positive Gynecological Cancer Cells: In Vitro and In Vivo Characterization

Pharmaceuticals, 2017
The folate receptor (FR) is expressed in a variety of gynecological cancer types. It has been widely used for tumor targeting with folic acid conjugates of diagnostic and therapeutic probes.
Klaudia Siwowska, Raffaella M. Schmid, Susan Cohrs, Roger Schibli, Cristina Müller   +4 more
doaj   +1 more source

[68Ga]/[188Re] Complexed [CDTMP] Trans-1,2-Cyclohexyldinitrilotetraphosphonic Acid As a Theranostic Agent for Skeletal Metastases

Frontiers in Medicine, 2017
ObjectiveMetastasis of the osseous tissue is one of the frequent and severe aggravations as a result of several neoplastic conditions, such as metabolic disorders, infections, and cancer.
Ambika P. Jaswal, Virendra K. Meena, Surbhi Prakash, Ankita Pandey, Baljinder Singh, Anil K. Mishra, Puja P. Hazari   +6 more
doaj   +1 more source

A Step-by-Step Guide for the Novel Radiometal Production for Medical Applications: Case Studies with ⁶⁸Ga, ⁴⁴Sc, ¹⁷⁷Lu and ¹⁶¹Tb

Molecules, 2020
The production of novel radionuclides is the first step towards the development of new effective radiopharmaceuticals, and the quality thereof directly affects the preclinical and clinical phases.
Zeynep Talip, Chiara Favaretto, Susanne Geistlich, Nicholas P. van der Meulen   +3 more
doaj   +1 more source

Radiopharmaceutical Formulation and Preclinical Testing of ⁶⁸Ga-Labeled DOTA-MGS5 for the Regulatory Approval of a First Exploratory Clinical Trial

, 2021
The new minigastrin analog DOTA-MGS5 is a promising new candidate for targeting cholecystokinin-2 receptor (CCK2R)-expressing tumors. To enable the clinical translation of PET/CT imaging using 68Ga-labeled DOTA-MGS5, different quality and safety aspects ...
Irene J. Virgolini, Elisabeth von Guggenberg, Maximilian Klingler, Christian Mair, Clemens Decristoforo, Anton A. Hörmann, Christian Uprimny, Christine Rangger   +7 more
core   +1 more source