Results 71 to 80 of about 7,465 (248)

Targeted Radiotherapeutics from 'Bench-to-Bedside'

CHIMIA, 2020
he concept of targeted radionuclide therapy (TRT) is the accurate and efficient delivery of radiation to disseminated cancer lesions while minimizing damage to healthy tissue and organs.
Cristina Müller, Martin Béhé, Susanne Geistlich, Nicholas P. van der Meulen, Roger Schibli   +4 more
doaj   +1 more source

Stability of Silver Nanoparticles as Imaging Materials [PDF]

Journal of Pure and Applied Chemistry Research, 2016
Determining the stability of silver nanoparticles is a very important process. It was associated with unwanted metal charge and materials properties. Therefore, we studied to synthesis and stability of silver nanoparticles (AgNPs).
Umi Nur Sholikhah, Anung Pujiyanto, Enny Lestari, Endang Sarmini, Triani Widyaningrum, Kadarisman, Triyanto, Putri Puspitasari   +7 more
doaj   +1 more source

Radiopharmaceuticals for Cancer Imaging and Therapy

Pharmaceutics, 2023
Nuclear medicine has emerged as a pivotal player in cancer patient care, revolutionizing the way cancer is detected, diagnosed, monitored, and treated [...]
Guy Bormans, Frederik Cleeren
doaj   +1 more source

The Development and Pilot Clinical Study of CD147 Targeted Antagonistic Peptide Probe for Tumor Imaging

Advanced Science, EarlyView.
This study establishes [68Ga]Ga‐DOTA‐AP9 as a first‐in‐human CD147‐targeted PET tracer with favorable safety and specific tumor uptake. Tracer accumulation correlates with CD147 expression in patients, enabling noninvasive quantification of CD147‐positive malignancies.
Xiaokun Ma, Rui Guo, Dongfeng Niu, Yufei Song, Zhenyao Zhang, Xiangxi Meng, Lili Mao, Haifeng Huang, Hua Zhu, Zhi Yang, Teli Liu   +10 more
wiley   +1 more source

Biomimetic Polymerization of Tellurocysteine: Breaking the Natural Amino Acid Radioprotection Limitation

Advanced Science, EarlyView.
Inspired by natural amino acid polymer‐melanin systems, this study strategically incorporated tellurocysteine to develop advanced radiation‐shielding materials. This approach transformed the primary interaction mechanism between melanin‐based materials and incident photons from Compton scattering to the photoelectric effect. Tellurocysteine‐polymerized
Wei Chen, Hanjie Zhu, Yue Zhang, Yuqing Qiao, Ruotong Deng, Huaping Xu, Wei Cao   +6 more
wiley   +1 more source

Comparison of desferrioxamine and NODAGA for the gallium-68 labeling of exendin-4

EJNMMI Radiopharmacy and Chemistry, 2019
Introduction Radiolabeled exendin-4 (Ex4) derivatives are used to target the glucagon-like peptide-1 receptor (GLP-1R) for the clinical diagnosis of insulinomas, a rare type of neuroendocrine tumor.
Simon A. M. Kaeppeli, Roger Schibli, Thomas L. Mindt, Martin Behe   +3 more
doaj   +1 more source

Radiosynthesis and Preclinical Evaluation of [99mTc]Tc-Tigecycline Radiopharmaceutical to Diagnose Bacterial Infections

Background/Objectives: As a primary source of mortality and disability, bacterial infections continue to develop a severe threat to humanity. Nuclear medicine imaging (NMI) is known for its promising potential to diagnose deep-seated bacterial infections.
Mohamed Fawzy Ramadan, Hassan Ali Almubarak, Abdullah M. Alkahtani, Maha Abdullah Momenah, Asma Noureen, Muhammad Shahzad Afzal, Tauqir A. Sherazi, Syeda Marab Saleem, Meshari A. Alsuwat, Tania Jabbar, Syed Ali Raza Naqvi, Hafiza Zahra Rab Nawaz, Muhammad Babar Imran   +12 more
core   +1 more source

Development and Validation of a GMP-Compliant High-Pressure Liquid Chromatography Method for the Determination of the Chemical and Radiochemical Purity of [¹⁸F]PSMA-1007, a PET Tracer for the Imaging of Prostate Cancer

, 2021
For the PET imaging of prostate cancer, radiotracers targeting the prostate-specific membrane antigen (PSMA) are nowadays used in clinical practice.
Klaus Kopka, Ute Hennrich, Heike Marx, Ines Katzschmann   +3 more
core   +1 more source

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

Advanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu, Zhenwen Zhao, Yangjie Wang, Zhigang Liu, Zhijie Liu, Xiaoling Li, Zhichen Mao, Lu Xu, Gan Lin, Gang Liu, Hongjuan Ma   +10 more
wiley   +1 more source

Terbium-149 production: a focus on yield and quality improvement towards preclinical application

Scientific Reports
Terbium-149 (T1/2 = 4.1 h, Eα = 3.98 MeV (16.7%), 28 µm range in tissue) is a radionuclide with potential for targeted alpha therapy. Due to the negligible emission of α-emitting daughter nuclides, toxicity to healthy tissue may be reduced in comparison ...
C. Favaretto, P. V. Grundler, Z. Talip, U. Köster, K. Johnston, S. D. Busslinger, P. Sprung, C. C. Hillhouse, R. Eichler, R. Schibli, C. Müller, N. P. van der Meulen   +11 more
doaj   +1 more source