Results 91 to 100 of about 362 (158)

Evaluation of folate receptor-alpha and other surface markers as potential targets for radionuclide therapy of ovarian cancer

EJNMMI Research
Background Epithelial ovarian cancer (EOC) has the highest mortality rate among gynecological malignancies, primarily due to frequent late-stage diagnosis and the development of resistance to chemotherapy.
Benjamin D. Hunkeler, Jakob Heimer, Ana Katrina Mapanao, Matthias Choschzick, Cristina Müller, Niels J. Rupp   +5 more
doaj   +1 more source

Increased Binding of [18F]Nifene, a PET Imaging Probe for α4β2* Nicotinic Acetylcholinergic Receptors in Hippocampus–Subiculum of Postmortem Human Parkinson's Disease Brain

Synapse, Volume 80, Issue 5, September 2026.
[18F]Nifene, a PET imaging probe for α4β2* nicotinic acetylcholine receptors, was used to discretely measure changes in hippocampus (HP) and subiculum (SUB) of postmortem Parkinson's disease (PD) cases compared to cognitively normal (CN) cases. Significant increased [18F]nifene binding in PD was observed.
Jogeshwar Mukherjee, Fariha Karim, Allyson Ngo, Christopher Liang, Geidy E. Serrano, Thomas G. Beach   +5 more
wiley   +1 more source

A Four‐Week Treatment With Dapagliflozin Is Associated With a Reduction in Insulin‐Stimulated Renal Cortical Glucose Uptake: A Post Hoc Analysis From a Pilot Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 9, Page 8329-8336, September 2026.
ABSTRACT Introduction and Objective Treatment with sodium‐glucose cotransporter‐2 inhibitors (SGLT‐2i) reduces the risk of both cardiovascular and renal outcomes in type 2 diabetes (T2D). The specific mechanism by which this happens has not yet been clarified.
Shawn Gugliandolo, Cassandra Morciano, Andrea Guarneri, Gian Pio Sorice, Marta Giaccari, Luigi Cappannoli, Umberto Capece, Amelia Splendore, Adriana Avolio, Lorenzo Diego Greco, Patricia Iozzo, Rossana Moroni, Alfredo Pontecorvi, Maria Lucia Calcagni, Francesco Burzotta, Domenico D'Amario, Filippo Crea, Lucia Leccisotti, Francesca Cinti   +18 more
wiley   +1 more source

<b>Indic-Origin Radiotheranostics: Integrating Indian Medicinal Botanicals into Next-Generation Radiopharmaceutical Science</b>

Vidhyayana
Despite radiotheranostics being at the forefront of Precision Oncology, most radiopharmaceuticals in use today are based on synthetic ligands and/or synthetic peptides, which are often costly and unavailable in many geographies (Hofman et al., 2020; Hope et al., 2019).
null Aswathy Rajesh, null Amy Sharon Janet, null Noyal Babu   +2 more
openaire   +1 more source

Sugar Amino Acid Linkers for the Design of [18F]SiFA‐PSMA Radioligands

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Sugar amino acid (SAA) linkers were incorporated into silicon‐fluoride‐acceptor (SiFA)‐prostate‐specific membrane antigen (PSMA) radioligands to modulate pharmacokinetic properties while preserving efficient 18F isotopic exchange radiolabeling. Furanose‐based SAAs outperformed pyranose analogues, enabling specific tumor visualization by PET despite ...
Narendar R. Gade, Melinda Wuest, Justin J. Bailey, Atul Bhardwaj, Ralf Schirrmacher, Frank Wuest   +5 more
wiley   +1 more source

Terbium sisters: current development status and upscaling opportunities

Frontiers in Nuclear Medicine
The interest in terbium radionuclides, which can be used in nuclear medicine, has increased tremendously over the last decade. Several research studies have shown the potential of four terbium radionuclides 149,152,155,161Tb both for cancer diagnosis as ...
Anzhelika N. Moiseeva, Chiara Favaretto, Chiara Favaretto, Zeynep Talip, Pascal V. Grundler, Nicholas P. van der Meulen, Nicholas P. van der Meulen   +6 more
doaj   +1 more source

Scanner‐agnostic artificial intelligence approach for fast bone scintigraphy

Journal of Applied Clinical Medical Physics, Volume 27, Issue 8, August 2026.
Abstract Purpose Current bone scintigraphy protocols often demand full‐count, 10–15 min scans to preserve image quality, and existing deep‐learning (DL) denoisers typically need to be retrained or retuned for each camera manufacturer. We introduce a scanner‐agnostic adaptive‐diffusion U‐Net designed to reconstruct diagnostic‐grade images from half‐time
Vinicius de Oliveira Menezes, Cleiton Cavalcante Queiroz, Antônio Augusto Silva Oliveira, Aurílio José dos Santos Filho, Allisson Francisco de Morais, Adriano de Oliveira Vigário, Maria Eduarda Flamini, Felipe Alves Mourato, Tsang Ing Ren, Marcos Antônio Dórea Machado   +9 more
wiley   +1 more source

Radiation safety management for stereotactic body radiation therapy incidentally concurrent with Pluvicto® (Lu‐177) therapy ‐ a case report

Journal of Applied Clinical Medical Physics, Volume 27, Issue 8, August 2026.
Abstract A patient with castration‐resistant prostate cancer (CRPC) was referred to our clinic seeking palliative management of a painful metastasis in the left pelvis. At the time of referral, the patient was receiving [177Lu]Lu‐PSMA 617 (Pluvicto®) therapy at an outside institution, with the next scheduled administration approaching within days.
Dongxu Wang, Bae P. Chu, Maria F. Chan, Jeonghoon Park, Yolanda Scott, Puneeth Iyengar, Matthew Williams   +6 more
wiley   +1 more source

Affinity‐Tuned Albumin Hitchhiking Extends the Bioorthogonal Capture Window in Pretargeting Radiotheranostics

Advanced Healthcare Materials, Volume 15, Issue 29, 7 August 2026.
Pharmacokinetic engineering of clickable radioligands was achieved via albumin hitchhiking approach within a pretargeted radiotheranostics delivery platform. This approach reduced rapid renal elimination, expanded bioorthogonal capture window, boosted tumor uptake by ∼3.5‐fold, and improved the tumor‐to‐liver ratio by ∼6‐fold.
Xie He, Nicholas L. Fletcher, Gayathri R. Ediriweera, Yifei Zhu, James Humphries, Christopher B. Howard, Jiazheng Wang, Craig A. Bell, Kristian Kempe, Kristofer J. Thurecht   +9 more
wiley   +1 more source

The Development and Pilot Clinical Study of CD147 Targeted Antagonistic Peptide Probe for Tumor Imaging

Advanced Science, Volume 13, Issue 46, 17 August 2026.
This study establishes [68Ga]Ga‐DOTA‐AP9 as a first‐in‐human CD147‐targeted PET tracer with favorable safety and specific tumor uptake. Tracer accumulation correlates with CD147 expression in patients, enabling noninvasive quantification of CD147‐positive malignancies.
Xiaokun Ma, Rui Guo, Dongfeng Niu, Yufei Song, Zhenyao Zhang, Xiangxi Meng, Lili Mao, Haifeng Huang, Hua Zhu, Zhi Yang, Teli Liu   +10 more
wiley   +1 more source