Results 61 to 70 of about 51,772 (325)

Flow optimization study of a batch microfluidics PET tracer synthesizing device. [PDF]

, 2010
We present numerical modeling and experimental studies of flow optimization inside a batch microfluidic micro-reactor used for synthesis of human-scale doses of Positron Emission Tomography (PET) tracers.
Daridon, Antoine, Elizarov, Arkadij M, Heath, James R, Huang, Jiang, Kolb, Hartmuth C, Meinhart, Carl, Miraghaie, Reza, van Dam, R Michael   +7 more
core   +4 more sources

Production Of 11C‐Labeled Amides Via “In‐Loop” 11C‐Carbonylation

Asian Journal of Organic Chemistry, EarlyView.
The current work utilizes carbon‐11 labelled aroyl dimethylaminopyridinium salts in a two‐step in‐loop carbonylative cross‐coupling reaction of aryl halides with [¹¹C]CO yielding a diverse range of carbon‐11 labelled primary benzamides with good to excellent yields.
Tanpreet Kaur, Xia Shao, Allen F. Brooks, Peter J. H. Scott   +3 more
wiley   +1 more source

166Dy/166Ho-labeled porous hydroxyapatite microparticles for treatment of inflammatory joint diseases – Exploring the advantages of in vivo generator

Scientific Reports
Holmium-166 [T½ = 26.8 h, Eβ − (max) = 1.74 MeV (48.7%) and 1.85 MeV (50.0%); Eγ = 80.6 keV (10.6%)] is one of the most promising radionuclides in radiation synovectomy (RSV) for the treatment of inflammatory joint diseases, especially of large joints ...
Sourav Patra, Khajan Singh, Avik Chakraborty, Shahiralam Khan Mohammed, Sutapa Rakshit, Rubel Chakravarty, Sudipta Chakraborty   +6 more
doaj   +1 more source

Supramolecular photodynamic agents for simultaneous oxidation of NADH and generation of superoxide radical

Nature Communications, 2022
Tumour hypoxia is a major issue for conventional photodynamic therapies, Here, the authors report on the supramolecular assembly of electron acceptors with photosensitizers which have improved reactive oxygen species production and are able to directly ...
Kun-Xu Teng, Li-Ya Niu, Nan Xie, Qing-Zheng Yang   +3 more
doaj   +1 more source

Preparation and Evaluation of Novel Folate Isonitrile ^99mTc Complexes as Potential Tumor Imaging Agents to Target Folate Receptors

Molecules, 2021
In order to seek novel technetium-99m folate receptor-targeting agents, two folate derivatives (CN5FA and CNPFA) were synthesized and radiolabeled to obtain [99mTc]Tc-CN5FA and [99mTc]Tc-CNPFA complexes, which exhibited high radiochemical purity (>95 ...
Junhong Feng, Xuran Zhang, Qing Ruan, Yuhao Jiang, Junbo Zhang   +4 more
doaj   +1 more source

Ethylenediamine- and propylenediaminediacetic acid derivatives as ligands for the "fac-[M(CO)3]+" core (M = Re, 99mTc) [PDF]

, 2006
The reaction of Re(CO)5Cl with o- or p-N-(nitrophenyl)ethylenediaminediacetic acid (H2L1, H2L2) and o- or p-N-(nitrophenyl)propylenediaminediacetic acid (H2L3, H2L4) in methanol leads to the formation of stable anionic [Et3NH][Re(CO)3(L)]·H2O complexes 1-
Allali, Mustapha, Beauchamp, André L., Benoist, Eric, Coulais, Yvon, Cousinié, Sandra, Dartiguenave, Michèle, Gressier, Marie, Tessier, Christian   +7 more
core   +1 more source

Premenopausal bilateral oophorectomy and Alzheimer's disease imaging biomarkers later in life

Alzheimer's &Dementia, EarlyView.
Abstract INTRODUCTION Premenopausal bilateral oophorectomy (PBO) before the age of 46 years is associated with an increased risk of dementia. We investigated the long‐term effects of PBO performed before age 50 years on amyloid beta (Aβ), tau, and neurodegeneration imaging biomarkers of Alzheimer's disease (AD).
Kejal Kantarci, Ekta Kapoor, Jennifer R. Geske, Anna Castillo, Julie A. Fields, Firat Kara, Evdokiya E. Knyazhanskaya, Christopher G. Schwarz, Matthew L. Senjem, Kent R. Bailey, Val Lowe, Nathan K. LeBrasseur, Walter A. Rocca, Michelle M. Mielke   +13 more
wiley   +1 more source

Euro-American discussion document on entry and advanced level practice in nuclear medicine [PDF]

, 2011
The European Association of Nuclear Medicine Technologist Committee (EANMTC) and the Society of Nuclear Medicine Technologist Section (SNMTS) meet biannually to consider matters of mutual importance. These meetings are held during the SNM and EANM annual
Hogg, P, Medvedec, H, Testanera, G, Waterstram-Rich, K   +3 more
core   +1 more source

Dopamine Transporter Imaging as Objective Monitoring Biomarker in Parkinson's Disease

Annals of Neurology, EarlyView.
Objective Although dopamine transporter (DaT) imaging is a valuable diagnostic biomarker, few studies have investigated its utility in objectively monitoring disease progression in patients with Parkinson's disease (PD). To date, no study has established a longitudinal relationship between the DaT signal decline and the motor symptom increase ...
Verena Dzialas, Gérard N. Bischof, Kathrin Möllenhoff, Alexander Drzezga, Thilo van Eimeren   +4 more
wiley   +1 more source

Activatable theranostic prodrug scaffold with tunable drug release rate for sequential photodynamic and chemotherapy

Smart Molecules
Glutathione (GSH)‐activated prodrugs are promising for overcoming the limitations of conventional anti‐tumor drugs. However, current GSH‐responsive disulfide groups exhibit unregulated reactivity, making it impossible to precisely control the drug ...
Si‐Yu Wang, Ying‐Hao Pan, Yu‐Chen Qu, Xiao‐Xiao Chen, Na Shao, Li‐Ya Niu, Qing‐Zheng Yang   +6 more
doaj   +1 more source