Results 61 to 70 of about 78,818 (344)
Aptamer-based therapeutics and their potential in radiopharmaceutical design [PDF]
, 2007 Aptamers, short, single stranded oligonucleotide entities, have been developed in the past 15 years against a plethora of targets and for a variety of applications.
Ferreira, Catia S. M. +1 more
core +3 more sources
Bioinorganic Chemistry and Applications, 2009 A neutral compound Re(CO)3(L) (L: 2-((2-(2,6-diethylphenylamino)-2-oxoethyl)(2-ethoxy-2-oxoethyl)amino)acetic acid, an IDA analogue) has been synthesized and evaluated for in vitro imaging probes of β-amyloid (Aβ) aggregates.
Yang Yang +3 more
doaj +1 more source
Регуляторные исследования и экспертиза лекарственных средств, 2021 Radiopharmaceuticals differ from other medicines mainly by the specific nature of their pharmacological action based on radioactivity, by absence of multiple-dose regimens, and by miniscule concentrations of the active pharmaceutical ingredient (10-9–10 ...
O. E. Klementyeva +2 more
doaj +1 more source
Insight into the Development of PET Radiopharmaceuticals for Oncology
Cancers, 2020 While the development of positron emission tomography (PET) radiopharmaceuticals closely follows that of traditional drug development, there are several key considerations in the chemical and radiochemical synthesis, preclinical assessment, and clinical ...
Joseph Lau +5 more
semanticscholar +1 more source
Experimental setup for light-to-heat NIR conversion measurements of gold nano-particles\u2019 solutions [PDF]
, 2018 In recent years, there is a constantly increasing interest in the application of nanoparticles for cancer diagnosis and cancer therapy. In this respect, the most promising nano-objects at present are the gold nanoparticles. A very convenient and powerful
Bello, Michele +3 more
core +2 more sources
Development of new copper-64 labeled rhodamine: a potential PET myocardial perfusion imaging agent
EJNMMI Radiopharmacy and Chemistry, 2022 Background Myocardial perfusion imaging (MPI) is one of the most commonly performed investigations in nuclear medicine procedures. Due to the longer half-life of the emerging positron emitter copper-64 and its availability from low energy cyclotron ...
Norah AlHokbany +5 more
doaj +1 more source
Microphysiological Solid Tumor Models in Hydrogel Beads for CAR T Cell Immunotherapy Evaluation
Advanced Science, EarlyView.The complex physical and biochemical barriers of the tumor microenvironment are major triggers of immune exclusion. Here, a 3D micrometastasis model is developed to mimic key microenvironmental cues, enabling in vitro evaluation of chimeric antigen receptor (CAR) T cell immunotherapy. Abstract Micrometastases are challenging to resect surgically and to
Xuan Peng +14 more
wiley +1 more source
Radiopharmaceutical Therapy [PDF]
Health Physics, 2019 Abstract Radiopharmaceutical therapy involves the use of radionuclides that are either conjugated to tumor-targeting agents (e.g., nanoscale constructs, antibodies, peptides, and small molecules) or that concentrate in tumors through natural physiological mechanisms that occur predominantly in neoplastic cells.
openaire +2 more sources
Advanced Science, EarlyView.Ligand topology and non‐coordination atoms are proved to be important for the design of effective water‐soluble actinide masking agents. Abstract Water‐soluble actinide‐masking ligands are fundamentally important for achieving efficient lanthanide/actinide separation and for the development of water‐soluble f‐block complexes for bioimaging and ...
Bin Li +9 more
wiley +1 more source
Application of chiral 2-isoxazoline for the synthesis of syn-1,3-diol analogs
Beilstein Journal of Organic Chemistry, 2019 The asymmetric cycloaddition of TIPS nitronate catalyzed by “Cu(II)-bisoxazoline” gave the 2-isoxazoline product in 95% yield, which was converted into tert-butyl (3S,5R)-6-hydroxy-3,5-O-isopropylidene-3,5-dihydroxyhexanoate in 14 steps through a β ...
Juanjuan Feng +3 more
doaj +1 more source