Results 41 to 50 of about 6,202 (205)

Targeted Radiotherapeutics from 'Bench-to-Bedside'

CHIMIA, 2020
he concept of targeted radionuclide therapy (TRT) is the accurate and efficient delivery of radiation to disseminated cancer lesions while minimizing damage to healthy tissue and organs.
Cristina Müller, Martin Béhé, Susanne Geistlich, Nicholas P. van der Meulen, Roger Schibli   +4 more
doaj   +1 more source

Rapid, efficient, and economical synthesis of PET tracers in a droplet microreactor: application to O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET). [PDF]

, 2019
BackgroundConventional scale production of small batches of PET tracers (e.g. for preclinical imaging) is an inefficient use of resources. Using O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET), we demonstrate that simple microvolume radiosynthesis ...
Chen, Bao Ying, Clark, Peter M, Fong, Kelly Mun-Ming, Lisova, Ksenia, van Dam, R Michael, Wang, Jia   +5 more
core   +1 more source

Ga(III) chelates of amphiphilic DOTA-based ligands : synthetic route and in vitro and in vivo studies [PDF]

, 2011
In this work we report a synthetic strategy of amphiphilic DOTA-based chelators bearing a variable size α-alkyl chain at one of the pendant acetate arms (from six to fourteen carbon atoms), compatible with their covalent coupling to amine-bearing ...
André, João P., Fontes, André Filipe Gomes Soares, Geraldes, Carlos F. G. C., Prata, M. Isabel M.   +3 more
core   +1 more source

High‐resolution deuterium metabolic imaging of the human brain at 9.4 T using phase‐cycled balanced SSFP spectral–spatial acquisitions

Magnetic Resonance in Medicine, Volume 95, Issue 3, Page 1304-1322, March 2026.
Abstract Purpose The aim was to improve the sensitivity and robustness against B0 inhomogeneities of deuterium metabolic imaging (DMI) using phase‐cycled balanced SSFP (bSSFP) methods at 9.4 T. Methods We investigated two variants of phase‐cycled bSSFP acquisitions, namely uniformly weighted multi‐echo and acquisition‐weighted chemical shift imaging ...
Praveen Iyyappan Valsala, Rolf Pohmann, Rahel Heule, Georgiy A. Solomakha, Nikolai I. Avdievich, Jörn Engelmann, Laura Kuebler, André F. Martins, Klaus Scheffler   +8 more
wiley   +1 more source

Integrating Nuclear Medicine Services Into Health Care Systems in Low‐ and Middle‐Income Countries: A Review of Challenges and Innovations

iRADIOLOGY, Volume 4, Issue 1, Page 3-12, February 2026.
Nuclear medicine is capable of solving noncommunicable diseases in LMICs but poses its own challenges. Research and investments are still needed. For nuclear medicine to answer the dynamics of noncommunicable diseases in the LMICs, it would have to overcome the high costs and regulations involved in this practice.
Biruk Demisse Ayalew, Saim Mahmood Khan, Helina K. Teklehaimanot, Zebeaman Tibebu Gorfu, Biniyam Jemaneh Batu, Zemichael Getu Alemayehu, Brook Lelisa Sime, Eyerusalem Kebede Zewde, Temesgen Mamo Sharew, Muhidin Ibrahim Hundisa, Yeamlak Tariku Tewodros, Jawairya Muhammad Hussain, Barina Khan   +12 more
wiley   +1 more source

Optimized, automated and cGMP-compliant synthesis of the HER2 targeting [68Ga]Ga-ABY-025 tracer

EJNMMI Radiopharmacy and Chemistry, 2023
Background The Affibody molecule, ABY-025, has demonstrated utility to detect human epidermal growth factor receptor 2 (HER2) in vivo, either radiolabelled with indium-111 (111In) or gallium-68 (68Ga).
Emma Jussing, Mélodie Ferrat, Mohammad M. Moein, Henrik Alfredéen, Tetyana Tegnebratt, Klas Bratteby, Erik Samén, Joachim Feldwisch, Renske Altena, Rimma Axelsson, Thuy A. Tran   +10 more
doaj   +1 more source

Advancements in Targeted Radiopharmaceuticals: Innovations in Diagnosis and Therapy for Enhanced Cancer Management

ChemBioChem, Volume 27, Issue 1, January 2026.
Radiopharmaceuticals enable precise cancer diagnosis and targeted therapy by combining radioactive isotopes with carrier molecules. This review summarizes advances from 2014 to 2025, emphasizing probe design, click chemistry, novel targets, and nanodelivery systems.
Mohd Sayeed Shaikh, Rupesh R. Kurhade, Abrar A. M. Siddiqui, Shaikh Shahbaz A. Majeed, Thomas J. Webster, Mohammad Intakhab Alam, Abdul Wasy Zia, Md. Faiyazuddin   +7 more
wiley   +1 more source

The Necessity of Using Heparin in an UltraTag™ RBC Kit when Tagging Blood for a Nuclear Medicine Study [PDF]

, 2016
The purpose of this research was to evaluate the need to use heparin when preparing an UltraTag red blood cell (RBC) kit for a nuclear medicine study.
Brehl, Nicholas C., Nielsen, Cybil J., Pigmon, Sarah R., Weatherman, Kara D.   +3 more
core   +1 more source

Astatine‐211—Towards In Vivo Stable Astatine‐211 Labeled Radiopharmaceuticals and Their (Pre)Clinical Applications

Medicinal Research Reviews, Volume 46, Issue 1, Page 203-237, January 2026.
ABSTRACT Targeted radioligand therapy has emerged as a promising treatment option for eradicating advanced cancer forms. α‐Emitters are considered particularly promising as they can obliterate (micro)‐metastases. The α‐emitter astatine‐211 (211At) has experienced increased interest due to its favorable decay properties.
Marius Müller, Nadia Bom Pedersen, Vladimir Shalgunov, Andreas Ingemann Jensen, Umberto Maria Battisti, Matthias Manfred Herth   +5 more
wiley   +1 more source

Brain Incidentalomas in Positron Emission Tomography: A Systematic Literature Review and Meta‐Analysis

Clinical Neuroimaging, Volume 3, Issue 1, 2026.
ABSTRACT Background and Purpose Over the past decades, whole‐body PET‐CT scanning has undergone considerable innovation, with a considerable increase in clinical indications becoming a key diagnostic imaging method. Subsequently PET is contributing to the growth in imaging incidentaloma rates, including those of the brain, a critical functional tissue.
Feras Chehade, Zainab Salman, Shorouk Hajeer, Joya Hadchiti, Jean ABI Ghosn, Linda Abou‐Abbas, Adam Bekkhoucha, Asaad Mohanna   +7 more
wiley   +1 more source