Results 51 to 60 of about 6,202 (205)

Implementation and validation of an in-house combined fluorescein/media-fill test to qualify radiopharmacy operators

EJNMMI Radiopharmacy and Chemistry, 2021
Background The purpose of this work was to design, validate and implement a media-fill test combined with fluorescein (MFT-F) for the specific qualification and training of radiopharmacy operators, in accordance with United States Pharmacopeia General ...
Cyril Fersing, Emmanuel Deshayes, Sarah Langlet, Laurence Calas, Vincent Lisowski, Pierre Olivier Kotzki   +5 more
doaj   +1 more source

Design, Synthesis, and Selective Antiproliferative Activity of Indolizine Derivatives as Microtubule Destabilizers

Archiv der Pharmazie, Volume 358, Issue 12, December 2025.
A series of indolizine derivatives was synthesized and biologically evaluated. Compounds 8e and 8h showed nanomolar antiproliferative activity against cancer cells and low toxicity to normal cells. They act as microtubule‐destabilizing agents, inducing G2/M arrest and modulating key proteins. Docking confirmed binding at the colchicine site of tubulin.
Victor Hugo Catricala Fernandes, Maitê Bueno Giometti, Franco Jazon Caires, Gabriel de Paula Bueno, Gabriel da Silva, Andréia Machado Leopoldino, Anna Junker, Giuliano Cesar Clososki   +7 more
wiley   +1 more source

Replenishment prioritization of highly perishable goods : a case study on nuclear medicine [PDF]

, 2007
Thesis (M. Eng. in Logistics)--Massachusetts Institute of Technology, Engineering Systems Division, 2007.Cataloged from PDF version of thesis.Includes bibliographical references (p.
Yea, Young-bai Michael, Zou, Hui
core  

Opportunities and Challenges of the Application of Nuclear Magnetic Resonance‐Based Cerebrospinal Fluid Metabolomics for Clinical Research

Chemistry–Methods, Volume 5, Issue 12, November 2025.
Cerebrospinal fluid (CSF) is an important diagnostic matrix in neurology. This review illustrates the potentials and pitfalls of current CSF analysis by nuclear magnetic resonance. Created with BioRender.com in BioRender. Berezhnoy, G. (2025) https://BioRender.com/x80l903. Web of Science is owned by Clarivate.
Georgy Berezhnoy, Jannik Sprengel, Claire Cannet, Nils Pompe, Christoph Trautwein   +4 more
wiley   +1 more source

Selection of DNA Aptamers Against Parathyroid Hormone for Electrochemical Impedimetric Biosensor System Development

Biotechnology and Applied Biochemistry, Volume 72, Issue 5, Page 1351-1362, October 2025.
ABSTRACT This work presents the pioneering development of an aptamer‐based electrochemical biosensor for real‐time monitoring of parathyroid hormone (PTH) levels, with a focus on intraoperative assessment during parathyroid surgery. It introduces, for the first time, the selection and characterization of aptamers targeting distinct segments of the PTH ...
Reza Didarian, Saharnaz Bargh, Almina Gülerman, Veli Cengiz Özalp, Özcan Erel, Nimet Yildirim‐Tirgil   +5 more
wiley   +1 more source

COX inhibition: Catalepsy and Striatum Dopaminergic-GABAergic-Glutamatergic Neurotransmission [PDF]

, 2008
Selective COX-2 and COX-1 inhibitors were administered (i.p. acutely) to normal and parkinsonian rats, followed by the analysis of the striatal dopamine, GABA and glutamate concentrations using the microdialysis technique, simultaneously, the catalepsy ...
Abbas Shafiee, Amin Gravand, Davood Barzegar-Pourshuraki, Hadi Fathi-Moghaddam, Hojat Ebrahiminik, Latifeh Navidpour, Mehdi Shafiee Ardestani, Meysam Shafiee Ardestani   +7 more
core   +1 more source

Superparamagnetic Iron Oxide Tracer: A Magnetic Match to Gold Standard in Melanoma Sentinel Lymph Node Biopsy—A Systematic Review and Meta‐Analysis

Journal of Surgical Oncology, Volume 132, Issue 5, Page 860-868, October 2025.
ABSTRACT Superparamagnetic iron oxide (SPIO) tracer is a potential option for sentinel lymph node biopsy (SLNB), though its application in melanoma remains minimally explored. This systematic review evaluated the use of SPIO tracer compared to the standard approach for SLNB in melanoma.
Kadhim Taqi, Eva Lindell Jonsson, Golpira Elmi Assadzad, Cecily Stockley, Ish Bains, Claire Temple‐Oberle   +5 more
wiley   +1 more source

Introducing bromine to the molecular structure as a strategy for drug design

Journal of Medical Science
Nowadays, the search for new pharmaceuticals has resulted in the development of thousands of new substances. One of the effective drug design strategies is to modify a previously obtained and studied substance.
Eduard Potapskyi, Karolina Kustrzyńska, Dawid Łażewski, Paulina Skupin-Mrugalska, Roman Lesyk, Marcin Wierzchowski   +5 more
doaj   +1 more source

Development of Carborane‐Based Halogenated Naphthyridinone‐Analogues as Cannabinoid Receptor Type 2 (CB2R) Ligands

ChemMedChem, Volume 20, Issue 17, September 11, 2025.
There is no suitable radioligand for positron emission tomography imaging of CB2R overexpression for routine clinical usage. Herein, the synthesis, characterization, binding affinity, and docking studies of carborane‐based halo‐substituted naphthyridinone derivatives as CB2R ligands are presented.
Lea Ueberham, Winnie Deuther‐Conrad, Peter Lönnecke, Aleksandr Kazimir, Evamarie Hey‐Hawkins   +4 more
wiley   +1 more source

Emerging Radiopharmaceuticals Beyond FDG for Ovarian Cancer: A Review of Advances in Nuclear Medicine

Cancer Medicine, Volume 14, Issue 17, September 2025.
Emerging radiopharmaceuticals in nuclear medicine could improve ovarian cancer diagnosis and staging, while also enabling assessment of treatment response, therapy resistance, and suitability for targeted therapies. ABSTRACT Aims This review summarizes the role and future prospects of nuclear medicine in ovarian cancer, focusing on novel ...
Mara M. K. Veenstra, Sophie Veldhuijzen van Zanten, Erik Vegt, Ingrid A. Boere, Heleen J. van Beekhuizen, Julie Nonnekens, Frederik A. Verburg, Maarten G. J. Thomeer   +7 more
wiley   +1 more source