Results 61 to 70 of about 6,202 (205)

The effect of radiolabeled nanostructured lipid carrier systems containing imatinib mesylate on NIH-3T3 and CRL-1739 cells

Drug Delivery, 2020
The aim of current study is to develop new nanostructured lipid carrier systems (NLCSs) containing imatinib mesylate (IMT) and evaluate their targeting efficiency on NIH-3T3 as fibroblast cells and CRL-1739 as gastric adenocarcinoma cells with ...
Evren Atlihan Gundogdu, Emine Selin Demir, Meliha Ekinci, Emre Ozgenc, Derya Ilem Ozdemir, Zeynep Senyigit, Makbule Asikoglu   +6 more
doaj   +1 more source

Development of a robotic prototype system for the preparation and partition of radioactive products [PDF]

, 2015
The ionizing radiation is used in the nuclear medicine field during the execution of diagnosis exams. The continuous exposure of humans to the radiation may cause organs and tissues damage, being its severity dependent of the quantity of the radiation ...
Baptista, Maria do Carmo, Guevara, Gabriela, Leitão, Paulo, Lima, José   +3 more
core   +1 more source

A pathway toward clinical translation of hyperpolarized [1,4‐13C2,2,3‐d2]fumarate as an imaging biomarker for early cellular necrosis in vivo

Magnetic Resonance in Medicine, Volume 94, Issue 3, Page 1202-1217, September 2025.
Abstract Purpose The detection of hyperpolarized carbon‐13 (HP 13C)‐fumarate conversion to 13C‐malate using 13C‐MRSI is a biomarker for early detection of cellular necrosis. Here, we describe the translation of HP 13C‐fumarate as a novel human imaging agent, including the evaluation of biocompatibility and scaling up of the hyperpolarization methods ...
Jonathan R. Birchall, Pascal Wodtke, Ashley Grimmer, Esben S. S. Hansen, Lotte B. Bertelsen, Nikolaj Bøgh, Marta Wylot, Maria J. Zamora‐Morales, Otso Arponen, Ines Horvat‐Menih, Elizabeth C. Latimer, Fung Tan, Evita Pappa, Johann Graggaber, Joseph Cheriyan, Kelly Holmes, Matthew J. Locke, Helen Sladen, Joan Boren, Mikko I. Kettunen, Anita Chhabra, Ian B. Wilkinson, Christoffer Laustsen, Kevin Brindle, Mary A. McLean, Ferdia A. Gallagher   +25 more
wiley   +1 more source

Radiopharmacy services in South African academic hospitals: implications for planning radiopharmacy services in Africa

Frontiers in Nuclear Medicine
BackgroundNuclear medicine (NM) is being embraced by undeveloped countries as a specialty. Due to the high costs involved in establishing new NM and radiopharmacy centres, proper planning is essential.
David Kimani, Beverley Summers, Lerato Mosima   +2 more
doaj   +1 more source

Imidazolium‐Based Lipid Analogs as Lipofection Reagents

Archiv der Pharmazie, Volume 358, Issue 8, August 2025.
Imidazolium‐based lipid analogs were synthesized and assessed for liposome‐mediated gene transfer. Cytotoxicity varied with alkyl chain saturation; di‐unsaturated analogs achieved effective transfection despite higher toxicity. These insights into the effects of lipid structure aid in designing efficient and safer nonviral delivery systems.
Marco Pierau, Ronewa Nematswerani, Calvin Dunker, Frank Glorius, Anna Junker   +4 more
wiley   +1 more source

Radiopharmaceuticals drug interactions: a critical review

Anais da Academia Brasileira de Ciências, 2008
Radiopharmaceuticals play a critical role in modern medicine primarily for diagnostic purposes, but also for monitoring disease progression and response to treatment.
Ralph Santos-Oliveira, Sheila W. Smith, Ana Maria A. Carneiro-Leão   +2 more
doaj   +1 more source

Development and characterisation of improved unifocal primary mouse lung cancer models with metastatic potential

The Journal of Pathology, Volume 266, Issue 4-5, Page 405-420, August 2025.
Abstract Lung cancer is the leading cause of cancer‐related death globally. To better understand the biology of lung cancer, mouse models have been developed using either tail vein‐injected tumour cell lines or genetically modified mice. The current gold‐standard models typically present with multiple lung foci.
Ana‐Rita Pedrosa, Alejandro Castillo‐Kauil, Yuliia Kravchuk, Louise Reynolds, Bruce Williams, David Moore, Cameron Lang, Srinivas Allanki, Eleni Maniati, Alexandros Hardas, Jozafina Haj, Rebecca Drake, Julie Cleaver, Julie Foster, Jana Kim, Ester Stern, Jane Sosabowski, Gilbert O. Fruhwirth, Erik Sahai, Ori Wald, Kairbaan Hodivala‐Dilke   +20 more
wiley   +1 more source

PPoma Review: Epidemiology, Aetiopathogenesis, Prognosis and Treatment

Diseases, 2018
Generally, pancreatic polypeptide-secreting tumor of the distal pancreas (PPoma) is classified as a rare tumor, and may occur sporadically or be associated in families or with multiple endocrine neoplasia type 1 (NEM 1).
Thais Ligiero Braga, Ralph Santos-Oliveira   +1 more
doaj   +1 more source

The evolving role of positron emission tomography in precision prostate cancer biopsy

European Journal of Clinical Investigation, Volume 55, Issue 8, August 2025.
Prostate biopsy plays a pivotal role in the detection and characterization of prostate cancer. PSMA PET‐targeted biopsy represents a significant advancement in prostate cancer diagnostics, offering higher sensitivity, specificity and accuracy in detecting clinically significant lesions compared to traditional methods. PSMA PET, when combined with mpMRI,
Alessio Imperiale, Valentina Berti, Roberto Luigi Cazzato, Darejan Mamulashvili Bessac, Alice Ressault, Luca Vaggelli, Mehdi Helali, Camilo Garcia, Hervé Lang, Desirée Deandreis, Luc Mertz, Afshin Gangi   +11 more
wiley   +1 more source

Guidance on validation and qualification of processes and operations involving radiopharmaceuticals

EJNMMI Radiopharmacy and Chemistry, 2017
Background Validation and qualification activities are nowadays an integral part of the day by day routine work in a radiopharmacy. This document is meant as an Appendix of Part B of the EANM “Guidelines on Good Radiopharmacy Practice (GRPP)” issued by ...
S. Todde, P. Kolenc Peitl, P. Elsinga, J. Koziorowski, V. Ferrari, E. M. Ocak, O. Hjelstuen, M. Patt, T. L. Mindt, M. Behe   +9 more
doaj   +1 more source