Results 71 to 80 of about 6,202 (205)

Histone Deacetylase 6 Brain PET in Amyotrophic Lateral Sclerosis‐Frontotemporal Spectrum Disorder

Annals of Clinical and Translational Neurology, Volume 12, Issue 7, Page 1350-1359, July 2025.
ABSTRACT Objective [18F]EKZ‐001 is a positron emission tomography (PET) tracer targeting histone deacetylase 6 (HDAC6), an enzyme responsible for intracellular transport and clearance of misfolded proteins. HDAC6 modulation is a promising treatment strategy in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS).
Greet Vanderlinden, Charles Carron, Donatienne Van Weehaeghe, Joke De Vocht, Fouke Ombelet, Pegah Masrori, Caro De Weerdt, Rebecca E. James, Lauren T. Evans, Frederick A. Schroeder, Jacob M. Hooker, Michel Koole, Janice E. Kranz, Tonya M. Gilbert, Philip Van Damme, Koen Van Laere   +15 more
wiley   +1 more source

GMP production of [18F]FE-PE2I on a TRACERLab FX2 N synthesis module, a radiotracer for in vivo PET imaging of the dopamine transport

EJNMMI Radiopharmacy and Chemistry
Background Parkinson's disease is a neurodegenerative disorder that is characterized by a degeneration of the dopaminergic system. Dopamine transporter (DAT) positron emission tomography (PET) imaging has emerged as a powerful and non-invasive method to ...
Mélodie Ferrat, Mohammad M. Moein, Carmen Cananau, Tetyana Tegnebratt, Paul Saliba, Fredrik Norman, Carsten Steiger, Klas Bratteby, Erik Samén, Kenneth Dahl, Thuy A. Tran   +10 more
doaj   +1 more source

Preclinical efficacy of hK2 targeted [177Lu]hu11B6 for prostate cancer theranostics [PDF]

, 2019
Androgen ablating drugs increase life expectancy in men with metastatic prostate cancer, but resistance inevitably develops. In a majority of these recurrent tumors, the androgen axis is reactivated in the form of increased androgen receptor (AR ...
Beattie, Bradley J., Beattie, Kai A., Elgqvist, Jörgen, Eriksson, Sophie E., Larsson, Erik, Strand, Sven-Erik, Thorek, Daniel L. J., Timmermand, Oskar Vilhelmsson, Tran, Thuy A., Ulmert, David, Örbom, Anders   +10 more
core   +2 more sources

AAPM Task Group No. 249.B—Essentials and guidelines for clinical medical physics residency training programs

Journal of Applied Clinical Medical Physics, Volume 26, Issue 6, June 2025.
Abstract The establishment of guidelines and curriculum standards for medical physics residency training is a critical component of setting expectations and competencies for the profession. Since the last publication of these standards, residency training has become integrated into the eligibility criteria for most medical physics certification bodies.
Jonathon A. Nye, Joseph P. Dugas, William D. Erwin, David P. Gierga, Darryl G. Kaurin, Stephanie M. Leon, Ho‐Ling Anthony Liu, Zheng Feng Lu, Alphonso W. Magri, Lynn N. Rill, Leah K. Schubert, Beth A. Schueler, Irina Vergalasova, John Vetter, Brian D. Wichman, Amy Shu‐Jung Yu, Dandan Zheng   +16 more
wiley   +1 more source

Towards Translational ImmunoPET/MR Imaging of Invasive Pulmonary Aspergillosis: The Humanised Monoclonal Antibody JF5 Detects Aspergillus Lung Infections In Vivo [PDF]

, 2017
This is the final published versionAvailable from Ivyspring International Publisher via the DOI in this recordInvasive pulmonary aspergillosis (IPA) is a life-threatening lung disease of hematological malignancy and bone marrow transplant patients caused
Boschetti, F, Davies, G, Denat, F, Dubois, A, Eichner, M, Foslet, J, Gunzer, M, Hasenberg, M, Jensen, M, Maurer, A, Pichler, BJ, Rolle, A-M, Ryder, LS, Schibli, R, Schillinger, C, Solouk-Saran, D, Spycher, PR, Thornton, CR, Weski, J, Wiehr, S   +19 more
core   +3 more sources

Anti-MUC1 nano-aptamers for triple-negative breast cancer imaging by single-photon emission computed tomography in inducted animals: initial considerations

International Journal of Nanomedicine, 2016
Fagner Santos do Carmo,1,2 Eduardo Ricci-Junior,3 Cristal Cerqueira-Coutinho,4 Marta de Souza Albernaz,1,5 Emerson Soares Bernardes,6 Sotiris Missailidis,7 Ralph Santos-Oliveira2 1Rio de Janeiro State University, Biology Institute Roberto Alcantara ...
Santos do Carmo F, Ricci-Junior E, Cerqueira-Coutinho C, Albernaz MS, Bernardes ES, Missailidis S, Santos-Oliveira R   +6 more
doaj  

Position paper on requirements for toxicological studies in the specific case of radiopharmaceuticals

EJNMMI Radiopharmacy and Chemistry, 2016
This is a position paper of the Radiopharmacy Committee of the EANM (European Association of Nuclear Medicine) addressing toxicology studies for application of new diagnostic and therapeutic radiopharmaceuticals (RP) that are not approved (i.e., not ...
J. Koziorowski, M. Behe, C. Decristoforo, J. Ballinger, P. Elsinga, V. Ferrari, P. Kolenc Peitl, S. Todde, T. L. Mindt   +8 more
doaj   +1 more source

Focal Spot, Spring 2008 [PDF]

, 2008
https://digitalcommons.wustl.edu/focal_spot_archives/1108/thumbnail ...

core   +1 more source

Focal Spot, Summer 2002 [PDF]

, 2002
https://digitalcommons.wustl.edu/focal_spot_archives/1091/thumbnail ...

core   +1 more source

P-glycoprotein at the blood-brain barrier: kinetic modeling of 11C-desmethylloperamide in mice using a 18F-FDG μPET scan to determine the input function [PDF]

, 2011
Purpose: The objective of this study is the implementation of a kinetic model for C-11-desmethylloperamide (C-11-dLop) and the determination of a typical parameter for P-glycoprotein (P-gp) functionality in mice.
Lieselotte Moerman, Dieter De Naeyer, Paul Boon, Filip De Vos   +3 more
core   +2 more sources