Results 71 to 80 of about 6,121 (195)
Histone Deacetylase 6 Brain PET in Amyotrophic Lateral Sclerosis‐Frontotemporal Spectrum Disorder
Annals of Clinical and Translational Neurology, Volume 12, Issue 7, Page 1350-1359, July 2025.ABSTRACT Objective [18F]EKZ‐001 is a positron emission tomography (PET) tracer targeting histone deacetylase 6 (HDAC6), an enzyme responsible for intracellular transport and clearance of misfolded proteins. HDAC6 modulation is a promising treatment strategy in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS).
Greet Vanderlinden +15 more
wiley +1 more source
Practical recommendations for radium-223 treatment of metastatic castration-resistant prostate cancer [PDF]
, 2017 is the first targeted alpha therapy for patients with castration resistant prostate cancer and symptomatic bone metastases. Radium-223 provides a new treatment option for this setting, but also necessitates a new treatment management approach.
Carrió, Ignasi +11 more
core +4 more sources
Journal of Applied Clinical Medical Physics, Volume 26, Issue 6, June 2025.Abstract The establishment of guidelines and curriculum standards for medical physics residency training is a critical component of setting expectations and competencies for the profession. Since the last publication of these standards, residency training has become integrated into the eligibility criteria for most medical physics certification bodies.
Jonathon A. Nye +16 more
wiley +1 more source
International Journal of Nanomedicine, 2016 Fagner Santos do Carmo,1,2 Eduardo Ricci-Junior,3 Cristal Cerqueira-Coutinho,4 Marta de Souza Albernaz,1,5 Emerson Soares Bernardes,6 Sotiris Missailidis,7 Ralph Santos-Oliveira2 1Rio de Janeiro State University, Biology Institute Roberto Alcantara ...
Santos do Carmo F +6 more
doaj
Molecules, 2020 Background: The frequent overexpression of gastrin-releasing peptide receptors (GRPRs) in human cancers provides the rationale for delivering clinically useful radionuclides to tumor sites using peptide carriers.
Panagiotis Kanellopoulos +6 more
doaj +1 more source
Advanced Science, Volume 12, Issue 21, June 5, 2025.Novel carbon‐11 labeled pyrimidine derivatives are developed as PET imaging probes for visualizing sigma‐1 receptors in the brain. [11C]CNY‐01 demonstrates superior brain uptake and binding specificity in both rodents and non‐human primates. The study reveals decreased sigma‐1 receptor expression in Alzheimer's disease, offering a promising tool for ...
Ping Bai +12 more
wiley +1 more source
EJNMMI Radiopharmacy and Chemistry, 2016 This is a position paper of the Radiopharmacy Committee of the EANM (European Association of Nuclear Medicine) addressing toxicology studies for application of new diagnostic and therapeutic radiopharmaceuticals (RP) that are not approved (i.e., not ...
J. Koziorowski +8 more
doaj +1 more source
COX inhibition: Catalepsy and Striatum Dopaminergic-GABAergic-Glutamatergic Neurotransmission [PDF]
, 2008 Selective COX-2 and COX-1 inhibitors were administered (i.p. acutely) to normal and parkinsonian rats, followed by the analysis of the striatal dopamine, GABA and glutamate concentrations using the microdialysis technique, simultaneously, the catalepsy ...
Abbas Shafiee +7 more
core +1 more source