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128 Overcoming Cancer Radioresistance Factors of radioresistance in prostate cancer
Radiotherapy and OncologyKrause, M., Dubrovska, A., Baumann, M.
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Correction to "Nanoparticles (NPs)-Meditated LncRNA AFAP1-AS1 Silencing to Block Wnt/β-Catenin Signaling Pathway for Synergistic Reversal of Radioresistance and Effective Cancer Radiotherapy". [PDF]
Adv Sci (Weinh)europepmc +1 more source
Radioresistance of Brain Tumors [PDF]
Cancers, 2016 Radiation therapy (RT) is frequently used as part of the standard of care treatment of the majority of brain tumors. The efficacy of RT is limited by radioresistance and by normal tissue radiation tolerance. This is highlighted in pediatric brain tumors where the use of radiation is limited by the excessive toxicity to the developing brain.
Jonathan Knisely +2 more
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Radioresistance in Glioblastoma and the Development of Radiosensitizers [PDF]
Cancers, 2020 Ionizing radiation is a common and effective therapeutic option for the treatment of glioblastoma (GBM). Unfortunately, some GBMs are relatively radioresistant and patients have worse outcomes after radiation treatment. The mechanisms underlying intrinsic radioresistance in GBM has been rigorously investigated over the past several years, but the ...
John M Buatti +2 more
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The Role of PI3K/AKT/mTOR Signaling in Tumor Radioresistance and Advances in Inhibitor Research
International Journal of Molecular SciencesCancer is a major threat to human health, and radiotherapy is a key treatment method. However, its effectiveness is often limited by tumor radioresistance.
Manfred Jücker
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Ion Transport and Radioresistance
2020Neoplastic transformation is associated with alterations of the ion transports across plasma and intracellular membranes. These alterations are crucial elements of the phenotypical reprogramming of the transformed cells and may promote adaptation to hypoxia, malignant progression, tumor spreading and metastasis, as well as therapy resistance.
Bastian, Roth, Stephan M, Huber
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GPR56/ADGRG1 Inhibits Mesenchymal Differentiation and Radioresistance in Glioblastoma [PDF]
Cell Reports, 2017 A mesenchymal transition occurs both during the natural evolution of glioblastoma (GBM) and in response to therapy. Here, we report that the adhesion G-protein-coupled receptor, GPR56/ADGRG1, inhibits GBM mesenchymal differentiation and radioresistance ...
Xianhua Piao +2 more
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Studies on radioresistance with HeLa cells. Establishment of a radioresistant line.
Radiation research, 1970resistance. To investigate the mechanism of acquiring radioresistance, subcultures from a single HeLa clone were irradiated with 1 kR of x-rays. The results suggest that in a homogeneous cell strain it is difficult to acquire radioresistance; mutation and selection must act together.
N, Muta, S, Koiwai
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Radiation Botany, 1964
Abstract A survey of forty-seven species of crucifers after dry seed irradiation shows that a high proportion (twenty-eight) have an LD 60 over 80 kr, seventeen of them range from 40 to 80 kr, and only for two species ( Hesperis matronalis L. and Matthiola incana R.Br.) is the LD 50 under 40 kr.
C. Gómez-Campo, L. Delgado
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Abstract A survey of forty-seven species of crucifers after dry seed irradiation shows that a high proportion (twenty-eight) have an LD 60 over 80 kr, seventeen of them range from 40 to 80 kr, and only for two species ( Hesperis matronalis L. and Matthiola incana R.Br.) is the LD 50 under 40 kr.
C. Gómez-Campo, L. Delgado
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Lysosomes Contribute to Radioresistance in Cancer
Cancer Letters, 2018Radiotherapy is one of the most widely used methods to treat human tumors. Efficacy is due mainly to the DNA damage it induces. However, tumor cells often develop responsive adaptiveness to radiation treatment to survive, which leads to radioresistance. Many cellular processes, such as DNA damage repair, cell cycle arrest and autophagy, are involved in
Donghai Wang, Xingang Li, Jian Wang
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