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The cellular interpretation of tumour radioresistance
Cancer Treatment Reviews, 1984The curative action of radiotherapy in neoplastic diseases is due to the sterilizing effect of ionizing radiations on clonogenic stem cells. With an increasing radiation dose, the number of surviving clonogenic cells (i.e. those cells capable of forming a tumour recurrence) decreases exponentially as in a serial dilution experiment, each radiation dose
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Radioresistant Mutants of L5178Y Cells
Radiation Research, 1969Radioresistant cultures of the L5178Y leukemia were obtained during continuous β-irradiation at 4.8 rads/hour by means of tritiated water incorporated in the culture medium. The development of radiation resistance in individual cultures after exposures of 39 days or more (total dose ≥ 4.6 krads) was shown to be due to the production of resistant ...
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Defining clinical radioresistance and radiosensitivity
The British Journal of Radiology, 1983Dr. Courdi (November 1982) draws our attention to the problems that arise when radiotherapists attempt to apply their concepts of radiosensitivity and radioresistance to non-standard clinical situations. His call for clarification of the terms should not ignore the fact that radiosensitivity already has a precise radiobiological meaning.
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The Role of Epithelial-Mesenchymal Transition in Regulating Radioresistance
Critical Reviews in Oncology/Hematology, 2020Haihua Yang, Mingxin Zhang, Suna Zhou
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DGKB Mediates Radioresistance by Regulating DGAT1-Dependent Lipotoxicity in Glioblastoma
Cell Reports Medicine, 2023BuHyun Youn, Haksoo Lee, Eunguk Shin
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