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Replication Stress in Cancer: Mechanistic Insights and Therapeutic Opportunities for Radiosensitization. [PDF]
Curr Issues Mol BiolVasilopoulos SN +6 more
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Correction to "MicroRNA-1275 induces radiosensitization in oesophageal cancer by regulating epithelial-to-mesenchymal transition via Wnt/β-catenin pathway". [PDF]
J Cell Mol Medeuropepmc +1 more source
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Biophysical radiosensitization
Radiation and Environmental Biophysics, 1983Experimental studies on normal and tumor-bearing rats revealed that chronic treatment with hydroquinone (5 mg/kg/day) inhibited catalase activity in liver, spleen, blood, and H 18R tumor. 3H-hydroquinone (1.5 microCi/g body weight) showed tumor specificity, with maximum radioactivity in the tumor at 1 h after administration. The biological half-time of
C, Vladescu, M, Apetroae
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Antimetabolite Radiosensitizers
Journal of Clinical Oncology, 2007Radiosensitization with antimetabolites has improved clinical outcome for patients with solid malignancies, especially cancers of the GI tract, cervix, and head and neck. Fluorouracil (FU) and hydroxyurea have been widely used clinically during the last four decades, and promising results have been observed more recently with gemcitabine. Although the
Donna S, Shewach, Theodore S, Lawrence
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Trends in Pharmacological Sciences, 2018
Radiotherapy (RT) is a mainstay treatment for many types of cancer, although it is still a large challenge to enhance radiation damage to tumor tissue and reduce side effects to healthy tissue. Radiosensitizers are promising agents that enhance injury to tumor tissue by accelerating DNA damage and producing free radicals.
Hao, Wang +3 more
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Radiotherapy (RT) is a mainstay treatment for many types of cancer, although it is still a large challenge to enhance radiation damage to tumor tissue and reduce side effects to healthy tissue. Radiosensitizers are promising agents that enhance injury to tumor tissue by accelerating DNA damage and producing free radicals.
Hao, Wang +3 more
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The British Journal of Radiology, 1979
Hendry and Sutton (1978) express concern about the possible sensitizing effect of misonidazole in normal tissues in patients treated with this drug combined with radiotherapy. Their argument is based upon the enhanced effect seen in human normal tissues following treatment in hyperbaric oxygen and upon observations in animals when radiotherapy is ...
G E, Adams, S, Dische
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Hendry and Sutton (1978) express concern about the possible sensitizing effect of misonidazole in normal tissues in patients treated with this drug combined with radiotherapy. Their argument is based upon the enhanced effect seen in human normal tissues following treatment in hyperbaric oxygen and upon observations in animals when radiotherapy is ...
G E, Adams, S, Dische
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Organelle-localized radiosensitizers
Chemical Communications, 2020This feature article highlights the recent advances of organelle-localized radiosensitizers and discusses the current challenges and future directions.
Yuanyuan Chen +5 more
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[Radiosensitization by hypoxic cell radiosensitizer--present status of radiosensitizer].
Gan no rinsho. Japan journal of cancer clinics, 1991Because of the unsuccessful clinical trials of misonidazole (MISO), many efforts have been made to find a new hypoxic cell sensitizer which is more effective and/or less toxic than MISO. In Japan, RK-28 is already under going Phase II clinical evaluation and RP-170, KU-2285 and KIH-802 have been proven to be effective both in vitro and in vivo and are ...
C, Murayama, T, Mori
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Experientia, 1989
Many different methods exist by which the radiosensitivity of cells, and hence of normal tissues and tumours, can be manipulated. Several of these can be traced to a common redox pathway involving competition between oxidising and reducing species. Others involve the biochemical enzyme systems required for removal of DNA lesions.
A, Rojas, J, Denekamp
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Many different methods exist by which the radiosensitivity of cells, and hence of normal tissues and tumours, can be manipulated. Several of these can be traced to a common redox pathway involving competition between oxidising and reducing species. Others involve the biochemical enzyme systems required for removal of DNA lesions.
A, Rojas, J, Denekamp
openaire +2 more sources