Results 151 to 160 of about 18,687 (179)
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Anti-Cancer Drugs, 2014
In parallel with the discovery of the taxanes, our understanding of the molecular underpinnings that comprise the classic biologic principles of fractionated radiotherapy has rapidly evolved over the past half century. Early studies have implicated DNA as the primary target for radiation-induced lethality.
Encouse B, Golden +2 more
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In parallel with the discovery of the taxanes, our understanding of the molecular underpinnings that comprise the classic biologic principles of fractionated radiotherapy has rapidly evolved over the past half century. Early studies have implicated DNA as the primary target for radiation-induced lethality.
Encouse B, Golden +2 more
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Radioprotection by Radiosensitizers
1977The title to this paper was chosen to point deliberately upon the semantic problem involved in characterizing modifications of the response to radiation. In considering the multitarget single-hit model, cellular sensitivity can be modified in the sense of a change in the energy per lethal event and/or in the sense of a change in the amount of ...
L, Révész, B, Littbrand
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Parameters of Radiosensitivity
Radiation Research, 1986Dr. B. Fertil, Dr. E. P. Malaise, and co-workers have shown (1-5) that despite wide variability in the shapes of published in vitro survival curves for cells of human origin, there are, on average, systematic differences in the shapes of survival curves in the low-dose region among cells of distinct histological types.
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The British Journal of Radiology, 1978
In current radiotherapy trials with the oxygen-mimetic radiosensitizing drugs, which are expected to overcome the potential problem of resistant hypoxic tumour cells, no allowance is being made for sensitization of normal tissue. These new agents are competing with hyperbaric oxygen (HBO) for providing therapeutic benefit, and sensitization by HBO was ...
J H, Hendry, M L, Sutton
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In current radiotherapy trials with the oxygen-mimetic radiosensitizing drugs, which are expected to overcome the potential problem of resistant hypoxic tumour cells, no allowance is being made for sensitization of normal tissue. These new agents are competing with hyperbaric oxygen (HBO) for providing therapeutic benefit, and sensitization by HBO was ...
J H, Hendry, M L, Sutton
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[Radiosensitizer: hypoxic cell radiosensitizer].
Gan to kagaku ryoho. Cancer & chemotherapy, 1989There is a world-wide demand for a clinically usable sensitizer for radio-resistant hypoxic cells. After unsuccessful clinical trials of misonidazole, many efforts have been made to develop new sensitizers. In the U.S., Brown and others reported a new drug named SR-2508 (ethanidazole), which is now in phase II and III clinical trials.
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Radiosensitization and Nanoparticles
2015Nanomaterials have been shown to have physical and chemical properties that have opened new avenues for cancer diagnosis and therapy. Nanoconstructs that enhance existing treatments for cancer, such as radiation therapy, are being explored in several different ways. Two general paths toward nanomaterial-enabled radiosensitization have been explored: (1)
Tatjana, Paunesku +3 more
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The British Journal of Radiology, 1980
I should like to comment on the correspondence between Adams and Dische and Hendry and Sutton in The British Journal of Radiology (1979). These authors were debating the risk of sensitization of normal tissues by misonidazole at the dose levels of radiation and drug that are likely to be used clinically.
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I should like to comment on the correspondence between Adams and Dische and Hendry and Sutton in The British Journal of Radiology (1979). These authors were debating the risk of sensitization of normal tissues by misonidazole at the dose levels of radiation and drug that are likely to be used clinically.
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Chromosomes, Cancer, and Radiosensitivity
American Journal of Clinical Oncology, 1982Some specific chromosomal abnormalities are associated with certain cancers. The earliest description of such a specific association is the one of the Philadelphia chromosome and myelogenous leukemia (1960). Other congenital karyotype abnormalities are associated with specific cancers. Examples of these are Down's syndrome with leukemia and Klinefelter'
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