Results 231 to 240 of about 27,469 (292)

Ferroptosis Inducers as Promising Radiosensitizer Agents in Cancer Radiotherapy.

Current Radiopharmaceuticals, 2023
Radiotherapy (RT) failure has historically been mostly attributed to radioresistance. Ferroptosis is a type of controlled cell death that depends on iron and is caused by polyunsaturated fatty acid peroxidative damage. Utilizing a ferroptosis inducer may
Fatemeh-Jalali Zefrei, Mohammd Shormij, L. Dastranj, M. Alvandi, Z. Shaghaghi, Soghra Farzipour, Nasim Zarei-Polgardani   +6 more
semanticscholar   +1 more source

Biotin-Targeted Au(I) Radiosensitizer for Cancer Synergistic Therapy by Intervening with Redox Homeostasis and Inducing Ferroptosis.

Journal of Medicinal Chemistry, 2022
The search for highly selective sensitizers with a novel mechanism for tumor targeting therapy is of considerable interest. In this work, we have developed a series of new biotin-targeted Au(I) complexes.
Zhibin Yang, Sheng Huang, Yu Liu, Xingyu Chang, Yanshan Liang, Xi Li, Zhongren Xu, Shiyu Wang, Yunlong Lu, Yuan Liu, Wukun Liu   +10 more
semanticscholar   +1 more source

GMT8 aptamer conjugated PEGylated Ag@Au core-shell nanoparticles as a novel radiosensitizer for targeted radiotherapy of glioma.

Colloids and Surfaces B: Biointerfaces, 2022
Radiotherapy is one of the main treatment modalities for glioma, but the therapeutic efficacy is often limited by the radioresistance of tumor cells. The radiosensitization effects of silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs) on tumors ...
Dongdong Li, Jing Zhao, Jun Ma, Huiquan Yang, Xiaodong Zhang, Yuyu Cao, Peidang Liu   +6 more
semanticscholar   +1 more source

Biophysical radiosensitization

Radiation and Environmental Biophysics, 1983
Experimental studies on normal and tumor-bearing rats revealed that chronic treatment with hydroquinone (5 mg/kg/day) inhibited catalase activity in liver, spleen, blood, and H 18R tumor. 3H-hydroquinone (1.5 microCi/g body weight) showed tumor specificity, with maximum radioactivity in the tumor at 1 h after administration. The biological half-time of
C, Vladescu, M, Apetroae
openaire   +2 more sources

Antimetabolite Radiosensitizers

Journal of Clinical Oncology, 2007
Radiosensitization with antimetabolites has improved clinical outcome for patients with solid malignancies, especially cancers of the GI tract, cervix, and head and neck. Fluorouracil (FU) and hydroxyurea have been widely used clinically during the last four decades, and promising results have been observed more recently with gemcitabine. Although the
Donna S, Shewach, Theodore S, Lawrence
openaire   +2 more sources

Cancer Radiosensitizers

Trends in Pharmacological Sciences, 2018
Radiotherapy (RT) is a mainstay treatment for many types of cancer, although it is still a large challenge to enhance radiation damage to tumor tissue and reduce side effects to healthy tissue. Radiosensitizers are promising agents that enhance injury to tumor tissue by accelerating DNA damage and producing free radicals.
Hao, Wang, Xiaoyu, Mu, Hua, He, Xiao-Dong, Zhang   +3 more
openaire   +2 more sources

X-ray and NIR Light Dual-triggered Mesoporous Upconversion Nanophosphor/Bi Heterojunction Radiosensitizer for Highly Efficient Tumor Ablation.

Acta Biomaterialia, 2020
Developing a multi-functional radiosensitizer with high efficiency and low toxicity remains challenging. Herein, we report a mesoporous heterostructure radiosensitizer (UCNP@NBOF-FePc-PFA) containing Lu-based upconversion nanophosphor (UCNP) and Bi-based
Jie Liu, Jing Zhang, Fei Huang, Yong Deng, Bing Li, Ruizhuo Ouyang, Y. Miao, Yun Sun, Yuhao Li   +8 more
semanticscholar   +1 more source

MnO2@CeOx-GAMP radiosensitizer with oxygen vacancies depended mimicking enzyme-like activities for radiosensitization-mediated STING pathway activation.

Biomaterials
Activation of the stimulator of interferon genes (STING) pathway by radiotherapy (RT) has a significant effect on eliciting antitumor immune responses.
Meiling Tan, Zhimin Gao, Xinyi Wang, Xiaozhao Wang, Chen Lin, Yongxin Huang, Wei Chen, Yaru Zhang, Zhiyao Hou   +8 more
semanticscholar   +1 more source

The potential role of borophene as a radiosensitizer in boron neutron capture therapy (BNCT) and particle therapy (PT).

Biomaterials Science, 2020
The potential role of borophene as a radiosensitizer in PT and BNCT was investigated. Our study focused on two aspects: (1) the synthesis and characterization of borophene nanomaterials; and (2) biocompatibility and dose enhancement.
Pengyuan Qi, Qianyuan Chen, Dong Tu, Songhuan Yao, Yupeng Zhang, Jike Wang, C. Xie, C. Pan, Hao Peng   +8 more
semanticscholar   +1 more source

Ultrafast Synthesizing Bismuth Mesoporous Nanolitchi Radiosensitizer Loading High Dose DOX for CT-Guided Enhanced Chemoradiotherapy

ACS Applied Materials & Interfaces, 2019
Radiotherapy and chemotherapy are both common clinical treatment methods. The combination of the two treatments can decrease tumor recurrence. In this study, bismuth-based mesoporous litchi shaped Na0.2Bi0.8O0.35F1.91:20%Yb (NBOF) nanoparticles (NPs ...
Yunhua Xu, Ruizhuo Ouyang, Yu-Hao Li
exaly   +2 more sources