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Application of nanomedicine in radiotherapy sensitization
Frontiers in Oncology, 2023 Radiation therapy is an important component of cancer treatment. As research in radiotherapy techniques advances, new methods to enhance tumor response to radiation need to be on the agenda to enable enhanced radiation therapy at low radiation doses ...
Xiaoyu Song +7 more
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Photodissociation of bromine-substituted nitroimidazole radiosensitizers [PDF]
, 2023 Heavy elements and some nitroimidazoles both exhibit radiosensitizing properties through different mechanisms. In an effort to see how the overall radiosensitivity might be affected when the two radiosensitizers are combined in the same molecule, we ...
Kooser, Kuno, +36 more
core +3 more sources
Radiosensitization and apoptosis [PDF]
Oncogene, 1998 The toxicity of radiation to living tissues was discovered soon after the discovery of radioactivity itself and this toxicity is the basis for cancer therapy with radiation. Although this mode of therapy is often effective, its success is far from assured.
R J, Muschel +3 more
openaire +2 more sources
Radiation Damage Mechanisms of Chemotherapeutically Active Nitroimidazole Derived Compounds
Frontiers in Chemistry, 2019 Photoionization mass spectrometry, photoelectron-photoion coincidence spectroscopic technique, and computational methods have been combined to investigate the fragmentation of two nitroimidazole derived compounds: the metronidazole and misonidazole ...
Jacopo Chiarinelli +12 more
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Oxygen switches: Refueling for cancer radiotherapy
Frontiers in Oncology, 2023 Radiotherapy remains the major therapeutic intervention for tumor patients. However, the hypoxic tumor microenvironment leads to treatment resistance. Recently, a burgeoning number of nano-radiosensitizers designed to increase the oxygen concentration in
Xianghui Li +9 more
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Radiosensitizing Nucleosides [PDF]
JNCI Journal of the National Cancer Institute, 1996 Chemotherapeutic drugs that perturb nucleotide metabolism have the potential to produce substantial sensitization of tumor cells to radiation treatment. The process is called radiosensitization, and the agents that induce it are called radiosensitizers.
C J, McGinn, D S, Shewach, T S, Lawrence
openaire +2 more sources
Boron clusters (ferrabisdicarbollides) shaping the future as radiosensitizers for multimodal (chemo/radio/PBFR) therapy of glioblastoma [PDF]
, 2022 Glioblastoma multiforme (GBM) is the most common and fatal primary brain tumor, and is highly resistant to conventional radiotherapy and chemotherapy. Therefore, the development of multidrug resistance and tumor recurrence are frequent.
VV.AA. +3 more
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HDAC inhibitors as radiosensitizers [PDF]
Radiation therapy is one of the main anticancer therapies. However, there are considerable numbers of radioresistant carcinoma cells and severe adverse effects occasionally occur after radiation therapy.
Zhang, Yubin +6 more
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The Structure and Activity of Double-Nitroimidazoles. A Mini-Review
Scientia Pharmaceutica, 2018 Many interesting applications have been found for nitroimidazoles as therapeutic agents. Among others, some of these compounds can radiosensitize hypoxic tumor cells.
Justyna Żwawiak, Lucjusz Zaprutko
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Pharmaceutics, 2021 Noble metal nanoparticles, such as gold (Au NPs), platinum (Pt NPs), or palladium (Pd NPs), due to their highly developed surface, stability, and radiosensitizing properties, can be applied to support proton therapy (PT) of cancer.
Bartosz Klebowski +6 more
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