Results 1 to 10 of about 245,937 (119)

Role of hypoxia in the tumor microenvironment and targeted therapy

Frontiers in Oncology, 2022
Tumor microenvironment (TME), which is characterized by hypoxia, widely exists in solid tumors. As a current research hotspot in the TME, hypoxia is expected to become a key element to break through the bottleneck of tumor treatment.
Gaoqi Chen, Kaiwen Wu, Hao Li, Demeng Xia, Tianlin He   +4 more
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The Promise of Targeting Hypoxia to Improve Cancer Immunotherapy: Mirage or Reality?

Frontiers in Immunology, 2022
Almost all solid tumors display hypoxic areas in the tumor microenvironment associated with therapeutic failure. It is now well established that the abnormal growth of malignant solid tumors exacerbates their susceptibility to hypoxia.
Bassam Janji, Salem Chouaib, Salem Chouaib   +2 more
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Imaging of Tumor Hypoxia With Radionuclide-Labeled Tracers for PET

Frontiers in Oncology, 2021
The hypoxic state in a solid tumor refers to the internal hypoxic environment that appears as the tumor volume increases (the maximum radius exceeds 180-200 microns).
Yuan Huang, Junying Fan, Yi Li, Shaozhi Fu, Shaozhi Fu, Yue Chen, Yue Chen, Jingbo Wu, Jingbo Wu   +8 more
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Tumor Hypoxia Drives Genomic Instability

Frontiers in Cell and Developmental Biology, 2021
Cancer is a leading cause of death worldwide. As a common characteristic of cancer, hypoxia is associated with poor prognosis due to enhanced tumor malignancy and therapeutic resistance.
Ming Tang, Ming Tang, Emma Bolderson, Emma Bolderson, Kenneth J. O’Byrne, Kenneth J. O’Byrne, Kenneth J. O’Byrne, Derek J. Richard, Derek J. Richard   +8 more
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Changes in hypoxia level of CT26 tumors during various stages of development and comparing different methods of hypoxia determination. [PDF]

PLoS ONE, 2018
The aim of this study was to evaluate hypoxia level at various tumor developmental stages and to compare various methods of hypoxia evaluation in pre-clinical CT26 tumor model.
Łukasz Kiraga, Łukasz Cheda, Bartłomiej Taciak, Kamila Różańska, Katarzyna Tonecka, Aleksandra Szulc, Krzysztof Kilian, Emilia Górka, Zbigniew Rogulski, Tomasz P Rygiel, Magdalena Król   +10 more
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Hypoxia Contributes to Poor Prognosis in Primary IDH-wt GBM by Inducing Tumor Cells MES-Like Transformation Trend and Inhibiting Immune Cells Activity

Frontiers in Oncology, 2021
AimsTo reveal the influence of hypoxia on tumor cells and immune cells in primary IDH-wt glioblastoma patients.MethodsSingle-cell RNA-seq data and bulk RNA-seq data were acquired from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA ...
Zujian Xiong, Zujian Xiong, Zujian Xiong, Hongwei Liu, Hongwei Liu, Chenqi He, Chenqi He, Xuejun Li, Xuejun Li   +8 more
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Hypoxia signaling in cancer: Implications for therapeutic interventions

MedComm, 2023
Hypoxia is a persistent physiological feature of many different solid tumors and a key driver of malignancy, and in recent years, it has been recognized as an important target for cancer therapy.
Yan Zhuang, Kua Liu, Qinyu He, Xiaosong Gu, Chunping Jiang, Junhua Wu   +5 more
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The relevance between hypoxia-dependent spatial transcriptomics and the prognosis and efficacy of immunotherapy in claudin-low breast cancer

Frontiers in Immunology, 2023
IntroductionHypoxia is an important characteristic of solid tumors. However, spatial transcriptomics (ST) of hypoxia-associated heterogeneity is not clear.MethodsThis study integrated Spatial Transcriptomics (ST) with immunofluorescence to demonstrate ...
Huizhi Sun, Huizhi Sun, Yanlei Li, Yanhui Zhang, Xiulan Zhao, Xueyi Dong, Yuhong Guo, Jing Mo, Na Che, Xinchao Ban, Fan Li, Xiaoyu Bai, Yue Li, Jihui Hao, Danfang Zhang   +14 more
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W18O49@EP nanoparticles improve the anti-tumor effect of radiotherapy and photodynamic therapy by avoiding the limitation of hypoxia

Frontiers in Bioengineering and Biotechnology, 2022
Insufficient oxygen supply at the tumor site and hypoxia caused during tumor treatment lead to a poor therapeutic effect and poor prognosis. Therefore, effectively overcoming the problem of hypoxia in tumors and avoiding hypoxia that compromises the ...
Jianquan Wang, Jianquan Wang, Lingyun Hao, Lingyun Hao, Xinhua Li, Xinhua Li, Sen Liu   +6 more
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Distinct Tumor Microenvironment at Tumor Edge as a Result of Astrocyte Activation Is Associated With Therapeutic Resistance for Brain Tumor

Frontiers in Oncology, 2019
Tumor vasculatures and hypoxia are critical tumor micro-environmental factors associated with tumor response to the therapy and heterogeneous in both time- and location-dependent manner.
Chiu-Min Lin, Ching-Fang Yu, Ching-Fang Yu, Hsueh-Ya Huang, Hsueh-Ya Huang, Fang-Hsin Chen, Fang-Hsin Chen, Fang-Hsin Chen, Ji-Hong Hong, Ji-Hong Hong, Ji-Hong Hong, Chi-Shiun Chiang, Chi-Shiun Chiang, Chi-Shiun Chiang   +13 more
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