Results 41 to 50 of about 1,922,670 (308)

Microarray analysis of pathways involved in bladder cancer invasion and metastasis. [PDF]

, 2008
MDHypoxia-inducible genes have been linked to the aggressive phenotype of cancer. However, nearly all work on hypoxia-regulated genes has been conducted in vitro on cell lines.
Ord, Jonathan J
core   +2 more sources

Comprehensive analysis of hypoxia-related genes for prognosis, immune features, and drugs treatment strategy in gastric cancer using bulk and single-cell RNA-sequencing

Scientific Reports, 2022
Hypoxia is one of the malignant characteristics of solid tumors and is related to the multiple malignant characteristics of the tumor. No study has not yet reported a systematical analysis of the characteristics of hypoxia from single-cell resolution in ...
Guoqiang Tao, Chengwen Jiao, Yong Wang, Qi Zhou   +3 more
doaj   +1 more source

Effect of ultrasound combined with microbubbles therapy on tumor hypoxic microenvironment

Frontiers in Pharmacology
IntroductionTumor tissues exhibit significantly lower oxygen partial pressure compared to normal tissues, leading to hypoxia in the tumor microenvironment and result in resistance to tumor treatments.
Yuyi Feng, Danxia Qiu, Yangcheng He, Hai Jin, Liping Chen, Fen Xi, Zhiwen Hu, Yanlin Xie, Yucai Li, Minhua Lin, Pengxiao Sun, Yan He, Jianhua Liu   +12 more
doaj   +1 more source

Pathophysiological Response to Hypoxia — From the Molecular Mechanisms of Malady to Drug Discovery: Drug Discovery for Targeting the Tumor Microenvironment

Journal of Pharmacological Sciences, 2011
The tumor microenvironment, characterized by regions of hypoxia, low nutrition, and acidosis due to incomplete blood vessel networks, has been recognized as a major factor that influences not only the response to conventional anti-cancer therapies but ...
Hideko Nagasawa
doaj   +1 more source

The Effect of Hypoxia and Hypoxia-Associated Pathways in the Regulation of Antitumor Response: Friends or Foes?

Frontiers in Immunology, 2022
Hypoxia is an environmental stressor that is instigated by low oxygen availability. It fuels the progression of solid tumors by driving tumor plasticity, heterogeneity, stemness and genomic instability.
Raefa Abou Khouzam, Rania Faouzi Zaarour, Klaudia Brodaczewska, Bilal Azakir, Goutham Hassan Venkatesh, Jerome Thiery, Jerome Thiery, Stéphane Terry, Stéphane Terry, Stéphane Terry, Salem Chouaib, Salem Chouaib   +11 more
doaj   +1 more source

Quantitative hypoxia mapping using a self-calibrated activatable nanoprobe

Journal of Nanobiotechnology, 2022
Hypoxia is a distinguished hallmark of the tumor microenvironment. Hypoxic signaling affects multiple gene expressions, resulting in tumor invasion and metastasis.
Xin Feng, Yuhao Li, Shiyuan Zhang, Changjian Li, Jie Tian   +4 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Iridium complex, a phosphorescent light-emitting diode material, serves as a novel chemical probe for imaging hypoxic tumor tissues [PDF]

, 2007
Iridium complex, a promising organic light-emitting diode for next generation television displays, emits phosphorescence. Phosphorescence is quenched by oxygen. We used this oxygen-quenching feature for imaging tumor hypoxia.
Yasuhiko Iida, Keigo Endo, Masahiro Hosaka, Seiji Tobita, Toshiyuki Takeuchi, Toshitada Yoshihara, Shaojuan Zhang   +6 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Molecular responses to hypoxia in tumor cells

Molecular Cancer, 2003
Highly aggressive, rapidly growing tumors are exposed to hypoxia or even anoxia which occurs as a consequence of inadequate blood supply. Both hypoxia and consecutive hypoxia/reoxygenation exert a variety of influences on tumor cell biology.
Ibrahim Saleh M, Kunz Manfred
doaj   +1 more source