Results 31 to 40 of about 1,922,670 (308)

Anticipating metastasis through electrochemical immunosensing of tumor hypoxia biomarkers

, 2021
Metastasis is responsible for about 90% of cancer-associated deaths. In the context of solid tumors, the low oxygen concentration in the tumor microenvironment (hypoxia) is one of the key factors contributing to metastasis.
Pingarrón Carrazón, José Manuel, Campuzano Ruiz, Susana, Muñoz San Martín, Cristina, Gamella Carballo, María, Montero Calle, Ana, Barderas Manchado, Rodrigo, Pedrero Muñoz, María, Ana Montero-Calle, José M. Pingarrón, Rodrigo Barderas, Jordi Camps, Víctor Pérez-Ginés, Cristina Muñoz-San Martín, Susana Campuzano, María Pedrero, Maria Gamella, Meritxell Arenas   +16 more
core   +1 more source

Long-term exposure to hypoxia inhibits tumor progression of lung cancer in rats and mice

BMC Cancer, 2011
Background Hypoxia has been identified as a major negative factor for tumor progression in clinical observations and in animal studies. However, the precise role of hypoxia in tumor progression has not been fully explained.
Hales Charles A, Yu Lunyin
doaj   +1 more source

Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape

Journal of Hematology & Oncology, 2022
Hypoxia, a common feature of the tumor microenvironment in various types of cancers, weakens cytotoxic T cell function and causes recruitment of regulatory T cells, thereby reducing tumoral immunogenicity.
Qinghua Wu, Li You, Eugenie Nepovimova, Zbynek Heger, Wenda Wu, Kamil Kuca, Vojtech Adam   +6 more
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Triggering of erythropoietin production by hypoxia is inhibited by respiratory and metabolic acidosis [PDF]

, 1990
Erythropoietin (EPO) production in response to hypoxic hypoxia is known to be attenuated by simultaneous hypercapnia. This study aimed to investigate whether this inhibitory effect of hypercapnia is 1) a direct effect of carbon dioxide or mediated by ...
Eckardt, K. U., Kurtz, Armin, Bauer, C., A. Kurtz, C. Bauer, K. U. Eckardt, Kurtz, A., Eckardt KU, Bauer C, Kurtz A   +9 more
core   +1 more source

Stromal Expression of Hypoxia Regulated Proteins Is an Adverse Prognostic Factor in Colorectal Carcinomas

Cellular Oncology, 2007
Background: Hypoxia modifies the phenotype of tumors in a way that promotes tumor aggressiveness and resistance towards chemotherapy and radiotherapy.
Arjen H. G. Cleven, Manon van Engeland, Bradly G. Wouters, Adriaan P. de Bruïne   +3 more
doaj   +1 more source

Accomplices of the Hypoxic Tumor Microenvironment Compromising Antitumor Immunity: Adenosine, Lactate, Acidosis, Vascular Endothelial Growth Factor, Potassium Ions, and Phosphatidylserine

Frontiers in Immunology, 2017
In this minireview, we aim to highlight key factors of the tumor microenvironment, including adenosine, lactate, acidosis, vascular endothelial growth factor, phosphatidylserine, high extracellular K+ levels, and tumor hypoxia with respect to antitumor ...
Peter Vaupel, Gabriele Multhoff
doaj   +1 more source

The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to developing treatment

Cancer Cell International, 2021
Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of abnormal blood vessels supplying the tumor.
Asieh Emami Nejad, Simin Najafgholian, Alireza Rostami, Alireza Sistani, Samaneh Shojaeifar, Mojgan Esparvarinha, Reza Nedaeinia, Shaghayegh Haghjooy Javanmard, Marjan Taherian, Mojtaba Ahmadlou, Rasoul Salehi, Bahman Sadeghi, Mostafa Manian   +12 more
doaj   +1 more source

Hypoxia-induced reactive oxygen species cause chromosomal abnormalities in endothelial cells in the tumor microenvironment. [PDF]

PLoS ONE, 2013
There is much evidence that hypoxia in the tumor microenvironment enhances tumor progression. In an earlier study, we reported abnormal phenotypes of tumor-associated endothelial cells such as those resistant to chemotherapy and chromosomal instability ...
Miyako Kondoh, Noritaka Ohga, Kosuke Akiyama, Yasuhiro Hida, Nako Maishi, Alam Mohammad Towfik, Nobuo Inoue, Masanobu Shindoh, Kyoko Hida   +8 more
doaj   +1 more source

A multi-omics deep learning model for hypoxia phenotype to predict tumor aggressiveness and prognosis in uveal melanoma for rationalized hypoxia-targeted therapy

Computational and Structural Biotechnology Journal, 2022
Uveal melanoma (UM) represents the most common primary intraocular malignancy in adults and is characterized by aggressive behaviors and a lack of targeted therapies.
Jingting Zhao, Quanyong Yi, Ke Li, Lu Chen, Lijun Dai, Jiayao Feng, Yan Li, Meng Zhou, Jie Sun   +8 more
doaj   +1 more source

Hypoxia and Cancer: From Bench to Bedside

, 2023
This Special Issue of Cancers (two original articles, five reviews), presented by international experts in tumor hypoxia, focuses on the role of hypoxia, or low oxygen levels, in the development and progression of cancer [...
Qingyu Zhou, Lingzhi Wang
core   +1 more source