Results 11 to 20 of about 1,922,670 (308)
International Journal of Nanomedicine, 2019 Jiajun Liu, Zeying Liu, Daocheng Wu Key Laboratory of Biomedical Information Engineering of Education Ministry, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi, China Abstract: Hypoxia is a common feature of
Liu J, Liu Z, Wu D
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Hypoxia and the Tumor Microenvironment [PDF]
Technology in Cancer Research & Treatment, 2021 Hypoxia is an important feature of the tumor microenvironment, and is closely associated with cell proliferation, angiogenesis, metabolism and the tumor immune response. All these factors can further promote tumor progression, increase tumor aggressiveness, enhance tumor metastatic potential and lead to poor prognosis.
Yue Li, Long Zhao, Xiao-Feng Li
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Tumor Hypoxia and Circulating Tumor Cells [PDF]
International Journal of Molecular Sciences, 2020 Circulating tumor cells (CTCs) are a rare tumor cell subpopulation induced and selected by the tumor microenvironment’s extreme conditions. Under hypoxia and starvation, these aggressive and invasive cells are able to invade the lymphatic and circulatory systems.
Tinganelli W., Durante M.
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Clinical Cancer Research, 2006 In this issue of Clinical Cancer Research , Rajendran et al. ([1][1]) have assessed the value of pretherapy fluoromisonidazole (FMISO) positron emission tomography (PET) imaging, an indicator of tissue hypoxia, in predicting survival of 73 patients with head and neck cancers.
Inna, Serganova +3 more
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Hypoxia in microscopic tumors [PDF]
Cancer Letters, 2008 Tumor hypoxia has been commonly observed in a broad spectrum of primary solid malignancies. Hypoxia is associated with tumor progression, increased aggressiveness, enhanced metastatic potential and poor prognosis. Hypoxic tumor cells are resistant to radiotherapy and some forms of chemotherapy. Using an animal model, we recently showed that microscopic
Xiao-Feng, Li, Joseph A, O'Donoghue
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Journal of Nanobiotechnology, 2022 Despite considerable progress has been achieved in hypoxia-associated anti-tumor therapy, the efficacy of utilizing hypoxia-activated prodrugs alone is not satisfied owing to the inadequate hypoxia within the tumor regions.
Jie Lv +5 more
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DCE-MRI of Tumor Hypoxia and Hypoxia-Associated Aggressiveness [PDF]
Cancers, 2020 Tumor hypoxia is associated with resistance to treatment, aggressive growth, metastatic dissemination, and poor clinical outcome in many cancer types. The potential of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to assess the extent of hypoxia in tumors has been investigated in several studies in our laboratory.
Gaustad, Jon-Vidar +6 more
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Expression of DDX3 is directly modulated by hypoxia inducible factor-1 alpha in breast epithelial cells [PDF]
, 2011 DEAD box protein, DDX3, is aberrantly expressed in breast cancer cells ranging from weakly invasive to aggressive phenotypes and functions as an important regulator of cancer cell growth and survival.
Krishnamachary, B. +16 more
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Metabolic profiling of hypoxic cells revealed a catabolic signature required for cell survival [PDF]
, 2011 Hypoxia is one of the features of poorly vascularised areas of solid tumours but cancer cells can survive in these areas despite the low oxygen tension.
Tennant, D.A. +44 more
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Responses to hypoxia via mTOR : role in endothelial cell proliferation and HIF-1[alpha] stabilization [PDF]
, 2005 Ischemic cardiovascular disease and cancer are life-threatening disorders in human mortality. Intensive studies on the etiology of and therapeutics for the diseases are ongoing.
Li, Weimin
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