Results 21 to 30 of about 1,922,670 (308)
OncoImmunology, 2021 Hypoxia develops in germinal centers (GCs) induced by model antigens; however, it is unknown whether tumor-reactive GCs are also hypoxic. We identified GC hypoxia in lymph nodes (LNs) draining murine mammary tumors and lethally irradiated tumor cells ...
Natalie S Firmino +8 more
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The HIF-2alpha-Driven Pseudo-Hypoxic Phenotype in Tumor Aggressiveness, Differentiation, and Vascularization. [PDF]
, 2010 Cellular adaptation to diminished tissue oxygen tensions, hypoxia, is largely governed by the hypoxia inducible transcription factors, HIF-1 and HIF-2. Tumor hypoxia and high HIF protein levels are frequently associated with aggressive disease. In recent
Påhlman, Sven +9 more
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Hypoxia helps glioma to fight therapy [PDF]
, 2009 Despite major improvements in the surgical management the prognosis for patients bearing malignant gliomas is still dismal. Malignant gliomas are notoriously resistant to treatment and the survival time of patients is between 3-8 years for low-grade and
Amberger-Murphy, Verena +1 more
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Global gene expression profiling in three tumor cell lines subjected to experimental cycling and chronic hypoxia. [PDF]
PLoS ONE, 2014 Hypoxia is one of the most important features of the tumor microenvironment, exerting an adverse effect on tumor aggressiveness and patient prognosis.
Magdalena Olbryt +5 more
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Regulation of Tumor Microenvironment through YAP/TAZ under Tumor Hypoxia. [PDF]
Cancers (Basel)In solid tumors such as hepatocellular carcinoma (HCC), hypoxia is one of the important mechanisms of cancer development that closely influences cancer development, survival, and metastasis.
Choi SH, Kim DY, Kim DY.
europepmc +2 more sources
Global Status and Trends of Tumor Hypoxia: A Scientometric Analysis
Zhongliu Fangzhi Yanjiu, 2019 Objective This study aimed to explore the status quo, hot topics, and future prospects in the field of tumor hypoxia by scientometric analysis. Methods The literatures about tumor hypoxia were downloaded from the Web of Science Core Collection from ...
LIU Ming +5 more
doaj +1 more source
Molecular Cancer, 2022 Given that hypoxia is a persistent physiological feature of many different solid tumors and a key driver for cancer malignancy, it is thought to be a major target in cancer treatment recently.
Ruixue Bai +5 more
doaj +1 more source
Hypoxia-induced signaling in angiogenesis : role of mTOR, HIF and Angiotensin II [PDF]
, 2007 This thesis includes the work of four different projects I have been following during my time as a PhD student; (1) the characterization of mTOR-associated signaling and endothelial cell proliferation in response to hypoxia, and (2) identification of ...
Petrimpol, Marco Renato
core +1 more source
Imaging Cycling Tumor Hypoxia [PDF]
Cancer Research, 2010 Abstract Cycling hypoxia is now a well-recognized phenomenon in animal and human solid tumors. Cycling hypoxia can exist more than 100-μm distances from a microvessel, and some of these regions have been shown to exist adjacent to normal tissue.
Shingo, Matsumoto +3 more
openaire +2 more sources
Hypoxia activates IKK-NF-κB and the immune response in Drosophila melanogaster [PDF]
, 2014 Hypoxia, or low oxygen availability, is an important physiological and pathological stimulus for multicellular organisms. Molecularly, hypoxia activates a transcriptional programme directed at restoration of oxygen homoeostasis and cellular survival ...
Biddlestone, John +4 more
core +1 more source