Results 61 to 70 of about 1,922,670 (308)

Multimodal evaluation of hypoxia in brain metastases of lung cancer and interest of hypoxia image-guided radiotherapy

Scientific Reports, 2021
Lung cancer patients frequently develop brain metastases (BM). Despite aggressive treatment including neurosurgery and external-radiotherapy, overall survival remains poor.
Aurélien Corroyer-Dulmont, Samuel Valable, Jade Fantin, Laurent Chatre, Jérôme Toutain, Sylvain Teulier, Céline Bazille, Elise Letissier, Jérôme Levallet, Didier Divoux, Méziane Ibazizène, Stéphane Guillouet, Cécile Perrio, Louisa Barré, Sébastien Serres, Nicola R. Sibson, Françoise Chapon, Guénaëlle Levallet, Myriam Bernaudin   +18 more
doaj   +1 more source

Visualization of hypoxia in cancer cells from effusions in animals and cancer patients

Frontiers in Oncology, 2022
ObjectiveTumor hypoxia is frequently observed in primary solid malignancies, but the hypoxic status of tumor cells floating in body cavity effusions is largely unknown, especially in patients.
Yue Li, Yue Li, Yue Li, Long Zhao, Long Zhao, Yunlong Huo, Xianghong Yang, Yong Li, Hao Xu, Xiao-Feng Li, Xiao-Feng Li, Xiao-Feng Li   +11 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

International Conference «Tumor Hypoxia and Malignant Progression». October 1–4, 2008, House of Scientists of NASU, Kiev, Ukraine [PDF]

, 2008
Tumor hypoxia: pathophysiological and molecular mechanisms; Hypoxia and HIF-1: role in tumor progression; Evaluation of tumor oxygenation; Hypoxia-modulated tumor stroma; Hypoxia and glycolysis in tumor: mechanisms of interrelationship;Hypoxia and tumor ...
Hao, B., Lin, Y., Zhang, G., Shi, R., Huang, Z.   +4 more
core   +2 more sources

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Hypoxia and activation of hypoxia inducible factor alpha as influencers of inflammatory helper T cells in autoimmune disease – a link between cancer and autoimmunity

Frontiers in Immunology
As a part of the tumor microenvironment, hypoxia is an important hallmark in the tumor progression. Hypoxia is a condition in which the oxygen supply is not sufficient to sustain the cell demand.
Giovanni Almanzar, Juan Carlos Alarcon, Juan Carlos Alarcon, Ruth Garzon, Ana Maria Navarro, Alejandro Ondo-Méndez, Martina Prelog   +6 more
doaj   +1 more source

Intermittent hypoxia selects for genotypes and phenotypes that increase survival, invasion, and therapy resistance. [PDF]

PLoS ONE, 2015
Hypoxia in tumors correlates with greater risk of metastases, increased invasiveness, and resistance to systemic and radiation therapy. The evolutionary dynamics that links specific adaptations to hypoxia with these observed tumor properties have not ...
Daniel Verduzco, Mark Lloyd, Liping Xu, Arig Ibrahim-Hashim, Yoganand Balagurunathan, Robert A Gatenby, Robert J Gillies   +6 more
doaj   +1 more source

Hypoxia-degradable and long-circulating zwitterionic phosphorylcholine-based nanogel for enhanced tumor drug delivery

Acta Pharmaceutica Sinica B, 2021
Tumor microenvironment has been widely utilized for advanced drug delivery in recent years, among which hypoxia-responsive drug delivery systems have become the research hotspot. Although hypoxia-responsive micelles or polymersomes have been successfully
Shaojun Peng, Boshu Ouyang, Yongjie Xin, Wei Zhao, Shun Shen, Meixiao Zhan, Ligong Lu   +6 more
doaj   +1 more source

Common Responses of Tumors and Wounds to Hypoxia

The Cancer Journal, 2015
Hypoxia is a characteristic of tumors and wounds. Hypoxic cells develop 2 common strategies to face hypoxia: the glycolytic switch and the angiogenic switch. At the onset of hypoxia, alleviation of the Pasteur effect ensures short-term cell survival.
Payen, Valéry, Brisson, Lucie, Dewhirst, Mark, Sonveaux, Pierre   +3 more
openaire   +4 more sources