Results 51 to 60 of about 7,625 (228)

Lactylation‐Driven PROS1‐TYRO3‐CARF Signaling Promotes Therapy‐Induced Senescence Escape and Radioresistance in Meningioma

Advanced Science, EarlyView.
A glycolysis‐driven epigenetic switch promotes therapy resistance in meningioma. Increased lactate production enhances histone H3K27 lactylation, which activates PROS1 secretion. Secreted PROS1 engages TYRO3 signaling to degrade the senescence regulator CARF, allowing cancer cells to escape growth arrest.
Zhuohang Wang, Qixiang Zhang, Keman Liao, Xiaoyu Liu, Hongchi Zhang, Yunsheng Chen, Yuxiao Ma, Yikui Liu, Aoqian Xu, Yuhao Sun, Jiayi Chen, Liuguan Bian, Baofeng Wang   +12 more
wiley   +1 more source

Why Does the Type of Halogen Atom Matter for Radiosensitizing Properties of 5-Substituted 4-Thio-2′-Deoxyuridines?

Proceedings, 2019
In order to explain the unexpected difference between radiosensitizing. [...]
Paulina Spisz, Magdalena Zdrowowicz, Samanta Makurat, Witold Kozak, Konrad Skotnicki, Krzysztof Bobrowski, Janusz Rak   +6 more
doaj   +1 more source

Topological Quantum Biomaterials Enable Pyroptosis‐Senescence Coupling for Enhanced Colorectal Cancer Therapy

Advanced Science, EarlyView.
This work reports conceptually unprecedented topological quantum biomaterials derived from engineered Pd3Sn nanostrips for oncological applications. Their near‐Fermi‐level electronic architecture and superior interfacial charge transport facilitate ultrasound‐amplified redox reactions and efficient ROS generation.
Zilu Chen, Kun Mei, Yan Yang, Mengna Xu, Xinyue Dai, Renjun Gu, Fuqiong Zhou, Cheng Wang, Meiqi Chang, Yan Huang, Yu Chen   +10 more
wiley   +1 more source

Metabolizable lanthanum-coordination nanoparticles as efficient radiosensitizers for solid tumor therapy

, 2017
Metabolizable lanthanum-coordination nanoparticles have been rationally designed and used as novel nano-sized radiosensitizers for solid tumor therapy.
Tianbo Yang, Yanli Dou, Jiazi Hou, Wanxi Zhang, Yuan Liang   +4 more
core   +1 more source

Action of Carnosic Acid Against Melanoma: A Strategy for Selective Radiosensitization with Protection of Non-Tumoral Cells

Current Issues in Molecular Biology
Carnosic acid (CA) is a phenolic diterpene with high antioxidant activity that supports its radioprotective capacity. This study aims to determine whether the radiosensitizing effect of CA established in B16F10 melanoma cells also occurs in other melanin-
Amparo Olivares, Isabel de la Fuente, Daniel Gyingiri Achel, Ana María Mercado, José Antonio Garcia-Gamuz, María del Rosario Tudela, Miguel Alcaraz   +6 more
doaj   +1 more source

Amcinonide Exhibits Antitumor Effects in Radioresistant Colorectal Cancer Through the circRNF10/miR‐296‐5p/Snail Axis

Advanced Science, EarlyView.
Amcinonide (AMC), the FDA‐approved corticosteroid, was identified as a repurposed agent for radiation‐resistant colorectal cancer. AMC suppresses radiation‐induced epithelial–mesenchymal transition, migration, and invasion via the circRNF10/miR‐296‐5p/Snail axis.
Hyun Jeong Seok, Dong Hyeon Lee, Junhye Kwon, Ui Sup Shin, In Hwa Bae   +4 more
wiley   +1 more source

Role of Natural Radiosensitizers and Cancer Cell Radioresistance: An Update [PDF]

, 2016
Cancer originates from genetic mutations accumulation. Cancer stem cells have been depicted as tumorigenic cells that can differentiate and self-renew. Cancer stem cells are thought to be resistant to conventional therapy like chemotherapy and radiation ...
Abdul Basit Ashraf, Gulshan Parveen, Arif Malik, Mahmood Husain Qazi, Sulayman Waquar, Misbah Sultana, Mahmood Rasool, Aamer Qazi   +7 more
core   +1 more source

Facile preparation of silver based radiosensitizers via biomineralization method for enhanced in vivo breast cancer radiotherapy

, 2023
To solve the traditional radiotherapy obstacles, and also to enhance the radiation therapy efficacy various radiosensitizers have been developed. Radiosensitizers are promising agents that under X-ray irradiation enhance injury to tumor tissue by ...
Nosrati, Hamed, Ali Mohammadi, Javani, Siamak, BARSBAY, MURAT, ERTAŞ, YAVUZ NURİ, Yavuz Nuri Ertas, Jalil Charmi, Charmi, Jalil, Navid Mousazadeh, Yahya Kalantari, Hamed Rezaeejam, Mousazadeh, Navid, Ghaffarlou, Mohammadreza, Hossein Danafar, Mohammadi, Ali, Mohammadreza Ghaffarlou, Hamed Nosrati, Marziyeh Salehiabar, Kalantari, Yahya, Rezaeejam, Hamed, Salehiabar, Marziyeh, Murat Barsbay, Siamak Javani, Danafar, Hossein   +23 more
core   +1 more source

Tantalum–Zirconium Co‐Doped Metal–Organic Frameworks Sequentially Sensitize Radio–Radiodynamic–Immunotherapy for Metastatic Osteosarcoma

Advanced Science, 2023
Due to radiation resistance and the immunosuppressive microenvironment of metastatic osteosarcoma, novel radiosensitizers that can sensitize radiotherapy (RT) and antitumor immunity synchronously urgently needed.
Tao Li, Mingquan Gao, Zifei Wu, Junjun Yang, Banghui Mo, Songtao Yu, Xiaoyuan Gong, Jing Liu, Weidong Wang, Shenglin Luo, Rong Li   +10 more
doaj   +1 more source

DTX3 Suppresses the NPM3–RUVBL1 Axis to Inhibit Homologous Recombination Repair and Abrogate Tumor Radioresistance

Advanced Science, EarlyView.
Deltex 3 (DTX3) catalyzes K27‐linked ubiquitination of nucleophosmin 3 to disrupt homologous recombination repair and reverse tumor radioresistance. Low DTX3 predicts poor survival and radiotherapy recurrence, serving as a radiosensitizing therapeutic target.
Jia‐Hao Xiao, Chang‐Jun Xie, Yan‐Hua Chen, Hao Cheng, Shuang‐Hui Li, Wei Li, Ya‐Wen Bin, Rui‐Min He, Ying‐Qing Li, Ping Feng   +9 more
wiley   +1 more source