Results 111 to 120 of about 10,067 (250)

Potential Application of a Water‐Soluble Fullerene C60 Decorated with Diethylene Glycol in Treatment of Osteoarthritis

Advanced NanoBiomed Research, Volume 5, Issue 9, September 2025.
A new ethoxyethanol derivative of iminofullerene, F2, is synthesized and labeled with 99mTc to produce 99mTc‐F2. In vitro, compound F2 inhibits the activation of primary mouse bone marrow‐derived macrophages stimulated with lipopolysaccharide. Moreover, 99mTc‐F2 is selectively enriched in the injured joints of mice. Inflammatory macrophages play a role
Rui He, Alyssa Costello, Yanjie Liu, Weicheng Wang, Zhichang Zhang, Quanjun Cui, Xinlin Yang   +6 more
wiley   +1 more source

Automated Solid-Phase Radiofluorination Using Polymer-Supported Phosphazenes

Molecules, 2013
The polymer supported phosphazene bases PS-P2tBu and the novel PS-P2PEG allowed for efficient extraction of [18F]F− from proton irradiated [18O]H2O and subsequent radiofluorination of a broad range of substrates directly on the resin.
Bente Mathiessen, Fedor Zhuravlev
doaj   +1 more source

Fully automated radiosynthesis of [18F]LBT999 on TRACERlab FXFN and AllinOne modules, a PET radiopharmaceutical for imaging the dopamine transporter in human brain

EJNMMI Radiopharmacy and Chemistry, 2020
Background Fluorine labelled 8-((E)-4-fluoro-but-2-enyl)-3β-p-tolyl-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid methyl ester ([18F]LBT999) is a selective radioligand for the in vivo neuroimaging and quantification of the dopamine transporter by ...
Christine Vala, Céline Mothes, Gabrielle Chicheri, Pauline Magadur, Gilles Viot, Jean-Bernard Deloye, Serge Maia, Yann Bouvet, Anne-Claire Dupont, Nicolas Arlicot, Denis Guilloteau, Patrick Emond, Johnny Vercouillie   +12 more
doaj   +1 more source

Synthesis of a carbon‐11 labeled nonsteroidal antiandrogen as a potential radioligand for pet imaging of prostate cancer [PDF]

, 2001
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/91184/1/25804401116_ftp ...
Bonasera, Hobisch, Katzenellenbogen, Liu, Teutsch, Van Dort   +5 more
core   +1 more source

PET quantification of [18F]MPPF in the canine brain using blood input and reference tissue modelling [PDF]

, 2019
Numerous studies have shown that the serotonin(1A) (5-HT1A) receptor is implicated in the pathophysiology and treatment of several psychiatric and neurological disorders.
Bosmans, Tim, De Vos, Filip, Dobbeleir, André, Dockx, Robrecht, Goethals, Ingeborg, Pauwelyn, Glenn, Peremans, Kathelijne, Polis, Ingeborgh, Vanhove, Christian, Verhoeven, Jeroen, Vlerick, Lise   +10 more
core   +1 more source

Automated GMP production and long‐term experience in radiosynthesis of CB₁ tracer [¹⁸F]FMPEP‐d₂ [PDF]

, 2020
Salla Lahdenpohja, Thomas H. Keller, Sarita Forsbäck, Tapio Viljanen, Esa Kokkomäki, Riikka V. Kivelä, Jörgen Bergman, Olof Solin, Anna K. Kirjavainen   +8 more
openalex   +1 more source

Ionic Liquid Aided [11C]CO Fixation for Synthesis of 11C‐carbonyls

ChemistryOpen, Volume 14, Issue 7, July 2025.
Tributyl(ethyl)phosphonium oxopentenolate ([P4442][Pen]) is an ionic liquid used in a proof‐of‐concept study evaluating its utility to trap carbon‐11 (t1/2=20.4 min)‐labeled CO for preparation of amides, ureas and carbamates. Abstract Tributyl(ethyl)phosphonium oxopentenolate ([P4442][Pen]) is an ionic liquid developed to capture CO and has shown ...
Anton Lindberg, Narges Mokhtarinori, Zhenzhen Yang, Sheng Dai, Ilja Popovs, Neil Vasdev   +5 more
wiley   +1 more source

Development of Carbon‐11 Labeled Pyrimidine Derivatives as Novel Positron Emission Tomography (PET) Agents Enabling Brain Sigma‐1 Receptor Imaging

Advanced Science, Volume 12, Issue 21, June 5, 2025.
Novel carbon‐11 labeled pyrimidine derivatives are developed as PET imaging probes for visualizing sigma‐1 receptors in the brain. [11C]CNY‐01 demonstrates superior brain uptake and binding specificity in both rodents and non‐human primates. The study reveals decreased sigma‐1 receptor expression in Alzheimer's disease, offering a promising tool for ...
Ping Bai, Ashley Gomm, Chi‐Hyeon Yoo, Prasenjit Mondal, Fleur Marie Lobo, Hui Meng, Yanting Zhou, Weiyao Xie, Hsiao‐Ying Wey, Rudolph E. Tanzi, Can Zhang, Changning Wang, Yu Lan   +12 more
wiley   +1 more source

Design and Optimization of Coin-Shaped Microreactor Chips for PET Radiopharmaceutical Synthesis [PDF]

, 2010
An integrated elastomeric microfluidic device, with a footprint the size of a postage stamp, has been designed and optimized for multistep radiosynthesis of PET tracers. Methods: The unique architecture of the device is centered around a 5-µL coin-shaped
Daridon, Antoine, Elizarov, Arkadij M., Heath, James R., Huang, Jiang, Kolb, Hartmuth C., Padgett, Henry C., Shin, Young Shik, Shu, Jenny, Stout, David, van Dam, R. Michael   +9 more
core   +1 more source

Production Of 11C‐Labeled Amides Via “In‐Loop” 11C‐Carbonylation

Asian Journal of Organic Chemistry, Volume 14, Issue 6, June 2025.
The current work utilizes carbon‐11 labelled aroyl dimethylaminopyridinium salts in a two‐step in‐loop carbonylative cross‐coupling reaction of aryl halides with [¹¹C]CO yielding a diverse range of carbon‐11 labelled primary benzamides with good to excellent yields.
Tanpreet Kaur, Xia Shao, Allen F. Brooks, Peter J. H. Scott   +3 more
wiley   +1 more source