Results 121 to 130 of about 10,067 (250)

Optimized and Automated Radiosynthesis of [18F]DHMT for Translational Imaging of Reactive Oxygen Species with Positron Emission Tomography

Molecules, 2016
Reactive oxygen species (ROS) play important roles in cell signaling and homeostasis. However, an abnormally high level of ROS is toxic, and is implicated in a number of diseases.
Wenjie Zhang, Zhengxin Cai, Lin Li, Jim Ropchan, Keunpoong Lim, Nabil E. Boutagy, Jing Wu, John C. Stendahl, Wenhua Chu, Robert Gropler, Albert J. Sinusas, Chi Liu, Yiyun Huang   +12 more
doaj   +1 more source

Improved protocol for the radiosynthesis of [¹⁸F]FTC‐146: A potent and selective sigma‐1 receptor radioligand [PDF]

, 2023
Masoud Sadeghzadeh, Barbara Wenzel, Julia Nikodemus, Alexandru Florea, Fabian Hertel, Klaus Kopka, Andreas Vogg, Fabian Kießling, Felix M. Mottaghy   +8 more
openalex   +1 more source

Radiosynthesis and evaluation of a 68Ga‐labeled brominated benzamide derivative for detection of melanoma in small animals

Bulletin of the Korean Chemical Society, Volume 46, Issue 5, Page 540-546, May 2025.
Malignant melanoma has the highest mortality rate among skin cancers due to its aggressiveness and metastatic potential, and early diagnosis is important because treatment options are limited. We synthesized a brominated benzamide derivative labeled with 68Ga and evaluated its biological properties as a PET imaging probe.
Dagyeong Hong, Chaewon Lee, Boreum Song, Eunsu Kim, Yejin Seo, Jiyu Kim, Wookyeong Jeong, Seong‐Young Kwon, Dong‐Yeon Kim, Ayoung Pyo   +9 more
wiley   +1 more source

Improved automated one-pot two-step radiosynthesis of (S)-[18F]FETrp, a radiotracer for PET imaging of indoleamine 2,3-dioxygenase 1 (IDO1)

EJNMMI Radiopharmacy and Chemistry
Background (S)-[18F]FETrp is a promising PET radiotracer for imaging IDO1 activity, one of the main enzymes involved in the tryptophan metabolism that plays a key role in several diseases including cancers.
Aurélie Maisonial-Besset, David Kryza, Klaus Kopka, Sophie Levesque, Emmanuel Moreau, Barbara Wenzel, Jean-Michel Chezal   +6 more
doaj   +1 more source

Synthesis and pre-clinical evaluation of a [18F] fluoromethyl-tanaproget derivative for imaging of progesterone receptor expression [PDF]

, 2016
The estrogen receptor (ER) and progesterone receptor (PR) are over-expressed in ∼50% of breast cancer lesions, and used as biomarkers to stratify patients for endocrine therapy. Currently, immunohistochemical (IHC) assessment of these lesions from a core-
Aboagye, EO, Allott, L, Carroll, L, Kealey, S, Merchant, S, Miller, PW, Smith, G, Tittrea, V, Witney, TH   +8 more
core   +1 more source

Fully automated synthesis of [18F]T807, a PET tau tracer for Alzheimer’s disease [PDF]

, 2015
The authentic standard T807 and its nitro-precursor T807P as well as t-Boc-protected T807P precursor for radiolabeling were synthesized from (4-bromophenyl)boronic acid, 3-bromo-4-nitropyridine and 3-bromo-6-nitropyridine with overall chemical yield 27 ...
Gao, Mingzhang, Wang, Min, Zheng, Qi-Huang   +2 more
core   +1 more source

Procedures for the GMP-Compliant Production and Quality Control of [18F]PSMA-1007: A Next Generation Radiofluorinated Tracer for the Detection of Prostate Cancer

Pharmaceuticals, 2017
Radiolabeled tracers targeting the prostate-specific membrane antigen (PSMA) have become important radiopharmaceuticals for the PET-imaging of prostate cancer.
Jens Cardinale, René Martin, Yvonne Remde, Martin Schäfer, Antje Hienzsch, Sandra Hübner, Anna-Maria Zerges, Heike Marx, Ronny Hesse, Klaus Weber, Rene Smits, Alexander Hoepping, Marco Müller, Oliver C. Neels, Klaus Kopka   +14 more
doaj   +1 more source

Development of novel fluorine-18 labeled PET radioligands for monoamine oxidase B (MAO-B) [PDF]

, 2013
Monoamine oxidases (MAO-A and MAO-B) are important enzymes regulating the levels of monoaminergic neurotransmitters. Selectiv e and irreversible MAO-B inhibitors such as L -deprenyl and rasagiline are clinically used for the t reatment of ...
Nag, Sangram
core   +2 more sources

Step-by-step optimisation of the radiosynthesis of the brain HDAC6 radioligand [18F]FSW-100 for clinical applications

EJNMMI Radiopharmacy and Chemistry
Background Histone deacetylase 6 (HDAC6) is an emerging target for the treatment and diagnosis of proteinopathies. [18F]FSW-100 was recently developed as a promising brain-penetrating radioligand for HDAC6 PET imaging and the process validation of [18F ...
Tetsuro Tago, Jun Toyohara
doaj   +1 more source

Radiosynthesis and in vivo evaluation of a 18F-labelled styryl-benzoxazole derivative for β-amyloid targeting [PDF]

, 2013
The formation of β-amyloid deposits is considered a histopathological feature of Alzheimer′s disease (AD). In vivo molecular imaging by means of amyloid-avid radiotracers will allow for an early and conclusive diagnostic of AD.
Abrunhosa, A., Bergmann, R., Gano, L., Kniess, T., Morais, G. Ribeiro, Paulo, A., Santos, I.   +6 more
core   +1 more source