Results 111 to 120 of about 9,194 (267)

Effectiveness and Safety of Radium‐223 for Bone‐Metastatic Castration‐Resistant Prostate Cancer: The KYUCOG‐1901 Study

Cancer Science, EarlyView.
The KYUCOG‐1901 prospective multicenter study evaluated radium‐223 in 93 Japanese patients with bone‐metastatic castration‐resistant prostate cancer. Ra‐223 was well tolerated, produced meaningful declines in ALP, and yielded a median overall survival of 23.0 months. Early initiation in patients with lower disease burden and integration with subsequent
Masaki Shiota, Shuichi Tatarano, Tomomi Kamba, Toshiyuki Kamoto, Tsukasa Igawa, Naoya Masumori, Hirotsugu Uemura, Kensuke Mitsunari, Takayuki Sumiyoshi, Hiroji Uemura, Katsuyoshi Higashijima, Shoji Tokunaga, Masatoshi Eto   +12 more
wiley   +1 more source

Data from Radium-223 Treatment Increases Immune Checkpoint Expression in Extracellular Vesicles from the Metastatic Prostate Cancer Bone Microenvironment

, 2023
Ioulia Vardaki, Paul G. Corn, Emanuela Gentile, Jian H. Song, Namrata Madan, Anh Tuan Hoang, Nila U. Parikh, Leah Gandee, Yu‐Chen Lee, Song-Chang Lin, Guoyu Yu, Elmer Santos, Marites P. Melancon, Patricia Troncoso, Nora M. Navone, Gary E. Gallick, Eleni Efstathiou, Sumit K. Subudhi, Sue-Hwa Lin, Christopher J. Logothetis, Theocharis Panaretakis   +20 more
openalex   +1 more source

Compound Library Screening Identified Cladribine as a Novel Radiosensitizer for Prostate Cancer

Cancer Science, EarlyView.
The combination of cladribine and irradiation significantly suppressed the growth of DU145‐derived tumors compared with the DMSO plus irradiation group in the mouse model. In addition, it also elevated the percentage of γH2AX‐positive cells after irradiation.
Toshiki Oka, Koji Hatano, Shohei Katsuki, Tomohiro Kanaki, Shunsuke Inoguchi, Masaru Tani, Akihiro Yoshimura, Yuki Horibe, Yutong Liu, Nesrine Sassi, Yohei Okuda, Akinaru Yamamoto, Toshihiro Uemura, Gaku Yamamichi, Yu Ishizuya, Takuji Hayashi, Yoshiyuki Yamamoto, Taigo Kato, Atsunari Kawashima, Keisuke Tamari, Bangzhong Lin, Akiyoshi Tani, Kazutake Tsujikawa, Yutaka Takahashi, Kazuhiko Ogawa, Shawn E. Lupold, Norio Nonomura   +26 more
wiley   +1 more source

Correction: A real-world evaluation of radium-223 in combination with abiraterone or enzalutamide for the treatment of metastatic castration-resistant prostate cancer

, 2021
Stephanie I. Kim, Andy H. Szeto, Katherine P. Morgan, Blaine Brower, Mary Dunn, Amir H. Khandani, Paul A. Godley, Tracy L. Rose, Ethan Basch, Matthew I. Milowsky, Young E. Whang, Daniel J. Crona   +11 more
openalex   +4 more sources

On a data-driven mathematical model for prostate cancer bone metastasis

AIMS Mathematics
Prostate cancer bone metastasis poses significant health challenges, affecting countless individuals. While treatment with the radioactive isotope radium-223 ($ ^{223} $Ra) has shown promising results, there remains room for therapy optimization. In vivo
Zholaman Bektemessov, Laurence Cherfils, Cyrille Allery, Julien Berger, Elisa Serafini, Eleonora Dondossola, Stefano Casarin   +6 more
doaj   +1 more source

mCRPC: Radium-223 auch kombinierbar [PDF]

Im Focus Onkologie, 2016
Radium-223 verbesserte in der ALSYMPCA-Studie das Gesamtuberleben von Patienten mit kastrationsresistentem Prostatakarzinom und symptomatischen Knochenmetastasen deutlich im Vergleich zu Placebo. Nun liegen Daten zur Kombination von Radium-223 u. a. mit Abirateron oder Enzalutamid vor.
openaire   +1 more source

Effects of age and disease duration on the glycaemic outcomes and safety of insulin glargine 300 U/mL in people with type 2 diabetes in China: A post‐hoc analysis of the INITIATION study

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims To evaluate the glycaemic outcomes and safety of insulin glargine 300 U/mL (Gla‐300) in Chinese people with uncontrolled type 2 diabetes (T2D) by baseline age and disease duration. Materials and Methods INITIATION was a 24‐week, interventional, single‐arm study where adults with T2D (glycated haemoglobin [HbA1c] 7.5%–11.0%) received Gla ...
Liming Chen, Qiu Zhang, Binhong Duan, Xiaohong Wu, Hailong Wan, Binhong Wen, Jie Han, Haixia Liu, Caixian Yang, Weiwei Liu, Qin Du, Lei Kang, Minlu Zhang   +12 more
wiley   +1 more source

EFFICACY AND SAFETY OF RADIUM-223 AND STANDARD OF CARE IN PATIENTS WITH BREAST CANCER AND BONE METASTASIS: A SYSTEMATIC REVIEW AND META-ANALYSIS

Hematology, Transfusion and Cell Therapy
Summary: Radium-223 (Ra-223) has been used to treat metastatic bone disease in prostate cancer, improving overall survival and quality of life. Breast cancer often presents bone metastasis too, but it is often associated with other sites of disease.
Felipe Alves MOURATO, Lucas Yuji Gomes ITIKAWA, Débora Mendes BRAUN, Simone Cristina Soares BRANDÃO, Lauro WICHERT-ANA   +4 more
doaj   +1 more source

RioM‐1: A New Calcite Reference Material for U‐Pb LA‐ICP‐MS Geochronology

Geostandards and Geoanalytical Research, EarlyView.
Key Points RioM‐1 calcite was characterised for trace elements, U‐Pb geochronology, Sr and O isotopes using ID‐TIMS, LA‐ICP‐MS and SIMS. U‐Pb dates from ID‐TIMS and LA‐ICP‐MS across several independent laboratories returned identical results within uncertainty.
Marco Silva, Cristiano Lana, Ricardo Scholz, Ian Buick, Sandra Kamo, Nick M.W. Roberts, Axel Gerdes, Michael Wiedenbeck, Blair Schoene, Francisco E. Apen, Sean P. Gaynor   +10 more
wiley   +1 more source

Radium-223-chloride

Reactions Weekly
Pinto, Álvaro, Cruz, Patricia
  +7 more sources