Results 41 to 50 of about 14,947 (171)

Composition analysis and toxigenic fungi isolation on the surface of Polygala Radix in China

, 2023
Abstract Purpose Polygalae Radix (PR) has been widely used in traditional Chinese medicine for decades. Aflatoxins easily contaminate PR during cultivation, harvesting and storage. However, which fungus produces these toxins on the surface PR is unknown.
Xuyu Chen, xiangsheng Zhao, Haimei Chen, Chang Liu, meihua Yang   +4 more
openaire   +1 more source

Identification of protein targets for the antidepressant effects of Kai-Xin-San in Chinese medicine using isobaric tags for relative and absolute quantitation

Neural Regeneration Research, 2020
Kai-Xin-San consists of Ginseng Radix, Polygalae Radix, Acori Tatarinowii Rhizoma, and Poria at a ratio of 3:3:2:2. Kai-Xin-San has been widely used for the treatment of emotional disorders in China.
Xian-Zhe Dong, Dong-Xiao Wang, Tian-Yi Zhang, Xu Liu, Ping Liu, Yuan Hu   +5 more
doaj   +1 more source

Multi-target regulatory mechanism of Yang Xin Tang − a traditional Chinese medicine against dementia

Chinese Medicine, 2023
Background Yang Xin Tang (YXT) is a traditional Chinese herbal preparation which has been reported to improve cognitive function and memory in patients with dementia.
Tung Yan Lo, Anthony Siu Lung Chan, Suet Ting Cheung, Lisa Ying Yung, Manton Man Hon Leung, Yung Hou Wong   +5 more
doaj   +1 more source

A Modified Chinese Herbal Decoction (Kai-Xin-San) Promotes NGF-Induced Neuronal Differentiation in PC12 Cells via Up-Regulating Trk A Signaling

Frontiers in Cell and Developmental Biology, 2017
Kai-Xin-San (KXS), a Chinese herbal decoction, has been applied to medical care of depression for thousands of years. It is composed of two functional paired-herbs: Ginseng Radix et Rhizoma (GR)-Polygalae Radix (PR) and Acori Tatarinowii Rhizoma (ATR ...
Lu Yan, Lu Yan, Lu Yan, Lu Yan, Min Wei, Min Wei, Amy G. Gong, Amy G. Gong, Pingping Song, Pingping Song, Jianshu Lou, Jianshu Lou, Cathy W. Bi, Cathy W. Bi, Sherry L. Xu, Aizhen Xiong, Tina T. Dong, Tina T. Dong, Karl W. Tsim, Karl W. Tsim   +19 more
doaj   +1 more source

Antidepressant-like effect of Radix Polygalae is associated with phosphorylation of hippocampal AMPA receptor GluR1 but not mTOR.

, 2014
(A) RP treatment (0.1 mg/kg p.o.) reduced hippocampal GluR1 phosphorylation (S845) but not when RP was co-administered with NBQX (10 mg/kg, i.p.) [F(2,15) = 4.38, p = 0.032]. There was no significant change in total GluR1 levels.
Sung Un Son (521287), Joo-Yeon Shin (521292), Seung-Hun Cho (521297), Jae-Hwan Lew (521296), Im-Joon Shin (521286), Sung Hyun Park (521290), Yoonju Cho (521294), Sungho Maeng (521298), Hyunwoo Park (521288), Yoorim Kim (521289), Kelley Swanberg (521291), Sang-Kyu Ha (521293), Soo-Yong Bang (521295)   +12 more
core   +1 more source

Saponins isolated from Radix polygalae extent lifespan by modulating complement C3 and gut microbiota

Pharmacological Research, 2021
With the increase in human lifespan, population aging is one of the major problems worldwide. Aging is an irreversible progressive process that affects humans via multiple factors including genetic, immunity, cellular oxidation and inflammation. Progressive neuroinflammation contributes to aging, cognitive malfunction, and neurodegenerative diseases ...
Wu, Zeng, An Guo, Wu, Xiao-Gang, Zhou, Imran, Khan, Rui Long, Zhang, Hang Hong, Lo, Li Qun, Qu, Lin Lin, Song, Xiao Yun, Yun, Hui Miao, Wang, Juan, Chen, Jerome P L, Ng, Fang, Ren, Si Yu, Yuan, Lu, Yu, Yong, Tang, Guo Xin, Huang, Vincent Kam Wai, Wong, Sookja Kim, Chung, Simon Wing Fai, Mok, Da Lian, Qin, Hua Lin, Sun, Liang, Liu, W L Wendy, Hsiao, Betty Yuen Kwan, Law   +24 more
openaire   +2 more sources

Evaluation of Storage Conditions and Pre‐Treatment Methods to Mitigate Aflatoxin Contamination in Commonly Used Chinese Herbal Medicines

Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.
High temperature and humidity significantly promote aflatoxin contamination in herbal medicines. This research demonstrates that drying, vacuum packaging, and sulfur fumigation are effective strategies to minimize contamination and extend shelf life, whereas UV exposure proves ineffective for decontamination.
Tung Leong Fong, Tingyuan Xing, Yau‐Tuen Chan, Zixin Feng, Guoyi Tang, Yibin Feng, Cheng Zhang, Ning Wang   +7 more
wiley   +1 more source

Kai-Xin-San series formulae alleviate depressive-like behaviors on chronic mild stressed mice via regulating neurotrophic factor system on hippocampus

Scientific Reports, 2017
Kai-xin-san (KXS) is a famous Chinese medicinal formula applied for treating stress-related psychiatric diseases with the symptoms such as depression, forgetfulness and dizziness.
Yue Zhu, Cheng Chao, Xiuzhu Duan, Xiaoxuan Cheng, Pei Liu, Shulan Su, Jinao Duan, Tina Tingxia Dong, Karl Wah-Keung Tsim   +8 more
doaj   +1 more source

MicroRNAs in Methamphetamine: Addiction, Neurotoxicity, and Therapeutic Potential

MedComm – Future Medicine, Volume 5, Issue 1, March 2026.
The use of METH leads to the release of dopamine from the affected brain regions, including the nucleus accumbens (NAc), ventral tegmental area (VTA), prefrontal cortex (PFC), hippocampus (Hip), and striatum. This triggers signals that alter miRNA expression, which in turn leads to differential expression of target genes.
Yacoubou Abdoul Razak Mahaman, An‐Ping Ye, Ya‐Xian Zhang, Ming‐Yu Chen, Fang Huang, Rong Liu, Ying‐Yan Fang, Xiaochuan Wang   +7 more
wiley   +1 more source

Acute-onset antidepressant-like effect of Radix Polygalae in mice.

, 2014
(A) Novelty suppressed feeding test. Latency to take a food pellet was reduced by RP (0.1 mg/kg, p.o.) administered 30 minutes before test, suggesting either rapid-onset anxiolytic or antidepressant-like effect ...
Sung Un Son (521287), Joo-Yeon Shin (521292), Seung-Hun Cho (521297), Jae-Hwan Lew (521296), Im-Joon Shin (521286), Sung Hyun Park (521290), Yoonju Cho (521294), Sungho Maeng (521298), Hyunwoo Park (521288), Yoorim Kim (521289), Kelley Swanberg (521291), Sang-Kyu Ha (521293), Soo-Yong Bang (521295)   +12 more
core   +1 more source