Results 111 to 120 of about 4,270,323 (214)

Five‐Year Trends in Biomarker Testing and Targeted Therapy for NSCLC: A Patient‐Initiated Nationwide Survey in Japan

Cancer Science, EarlyView.
This nationwide survey reveals that comprehensive multigene testing for advanced NSCLC has rapidly expanded in Japan, steadily increasing the use of targeted therapies for rare oncogenic drivers. Despite these diagnostic advancements, approximately 30% of patients consistently remain untested, highlighting a persistent clinical gap in real‐world ...
Satoshi Ikeda, Kazuo Hasegawa, Takayuki Takahama, Kenta Kachi, Akihiro Yanagisawa, Sachiko Kawakami, Masashi Yoshida, Miyuki Sakai, Sachiko Watanabe, Kazuhiko Nakagawa   +9 more
wiley   +1 more source

Cross-Talks between Raf Kinase Inhibitor Protein and Programmed Cell Death Ligand 1 Expressions in Cancer: Role in Immune Evasion and Therapeutic Implications

Cells
Innovations in cancer immunotherapy have resulted in the development of several novel immunotherapeutic strategies that can disrupt immunosuppression. One key advancement lies in immune checkpoint inhibitors (ICIs), which have shown significant clinical ...
Mai Ho, Benjamin Bonavida
doaj   +1 more source

Distinct Clinicogenomic Contexts of BRAF‐Altered Gliomas and Glioneuronal Tumors: A Nationwide Real‐World Study

Cancer Science, EarlyView.
Nationwide real‐world profiling revealed distinct clinicogenomic contexts across major BRAF alteration classes in gliomas and glioneuronal tumors. KIAA1549::BRAF fusion was associated with younger age and predominantly low‐grade tumors, whereas BRAF amplification‐only tumors were predominantly high‐grade and showed frequent MET amplification.
Seiji Yamada, Tetsuya Takimoto, Sayaka Ueno, Sachiko Minamiguchi, Shigeo Ohba, Yuichi Hirose, Hideyuki Saya, Tamotsu Sudo   +7 more
wiley   +1 more source

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

GSK3α‐mediated regulation of the RNA demethylase fat mass and obesity‐associated protein (FTO) during murine spermatogenesis

The FEBS Journal, EarlyView.
FTO regulates mRNA stability and translational efficiency through its m6A‐demethylation activity. GSK3 functions as an upstream regulator of FTO, leading to its inhibition via phosphorylation. In male germ cells, FTO activity is kept in check by GSK3α.
Neha Choudhari, Budheswar Dehury, Rounak Roy, Radhakrishnan Periyasamy, Indrashis Bhattacharya, Mahesh Sahare, Srinivasan Vijayraghavan, Souvik Dey   +7 more
wiley   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology
Lung adenocarcinoma (LUAD), the most common subtype of non‐small‐cell lung cancer (NSCLC), is often driven by mutations, particularly in epidermal growth factor receptor (EGFR), that guide targeted therapy choices. However, resistance to these treatments
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. daSilva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
doaj   +1 more source

Structural features of ZAK kinase regulation at the ribosome

The FEBS Journal, EarlyView.
ZAK kinase binds ribosomes in various states (hibernating, translating, and colliding). Widespread ribosome collisions promote ZAK autophosphorylation and activation of the ribotoxic stress response pathway. This stress signaling pathway mediates downstream cell fate decisions such as cell cycle arrest and apoptosis. ZAKα is a MAP3K that interacts with
Shuangshuang Niu, Vienna L. Huso, Roland Beckmann, Rachel Green   +3 more
wiley   +1 more source

Targeting B-Raf inhibitor resistant melanoma with novel cell penetrating peptide disrupters of PDE8A – C-Raf

, 2019
Background: Recent advances in the treatment of melanoma that involve immunotherapy and B-Raf inhibition have revolutionised cancer care for this disease.
Bruce H. Littman, Littman, Bruce H., Baillie, George S., George Baillie (6505871), Frank Marcoux (6505868), Bruce Littman (6505865), Walsh, Nicola, Marcoux, Frank W., Nicola M. Walsh, George S. Baillie, Blair, Connor M., Frank W. Marcoux, Connor Blair (6505862), Nicola Walsh (3402650), Connor M. Blair   +14 more
core   +1 more source

A guide to host genetic determinants of female microbiome composition across distinct anatomical niches

The FEBS Journal, EarlyView.
Host genetic variation in immune regulation and cell signalling genes was associated with microbiome composition across vaginal, gut, oral and skin sites, while associations involving metabolic function, epithelial barrier integrity and hormonal processes were more site‐specific. Overall, our findings indicate that host genetic variation contributes to
Isabella Margaret Davidson, Elham Nikbakht, Hayley O'Neill, Larisa Margaret Haupt, Paul Joseph Dunn   +4 more
wiley   +1 more source

Phosphotyrosine recognition by raf kinase inhibitor protein

, 2011
Raf kinase inhibitor protein (RKIP) negatively regulates the mitogen-activated protein kinase (MAPK) signaling cascade by direct interaction with Raf-1.
Simister, PC, Burton, NM, Brady, RL
core