Results 121 to 130 of about 4,270,323 (214)

Degradational and Transcriptional Investigations of the RAF Kinase Inhibitory Protein [PDF]

, 2016
RKIP (Raf-1 kinase inhibitory protein) is a novel potent metastasis suppressor by its function of inhibiting ERK pathway, NF-κB pathway, and GRK-2. RKIP expression level is reported to be critical in the differentiation process and the pathogenesis of ...
Yeh, Shih-Hao 1977-
core  

Kinetic signatures of RAS–BRAF engagement reveal isoform selectivity, oncogenic amplification, and mutation‐dependent inhibitor resistance

The FEBS Journal, EarlyView.
The BRAF N terminus uses a cooperative BSR–CRD gate that restricts RAS binding to the RBD, which can be mitigated by oncogenic RAS mutations. KRAS engages BRAF through stability‐driven, long‐lived complexes, whereas NRAS binds transiently in a frequency‐driven mode.
Sravani Malasani, Zhihong Wang
wiley   +1 more source

Secretory carrier membrane protein 3 modulates nuclear ERK1/2 signaling and drug response in triple-negative breast cancer

Frontiers in Oncology
IntroductionTriple-negative breast cancer (TNBC) frequently displays hyperactive mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinases 1/2 (ERK1/2) signaling but lacks tractable targets to sustain durable pathway inhibition ...
Beatriz M. Morales-Cabán, Millenia Jackson-González, Fernando A. Acosta-Pérez, Bryan S. Ortiz-Torres, Ivette J. Suárez-Arroyo   +4 more
doaj   +1 more source

Epigenetic and Metabolic Changes That Drive Trained Immunity in Response to Microbes and Vaccines

Immunology, EarlyView.
This graphical abstract illustrates how microbial products, vaccines and microbial metabolites activate pattern‐recognition receptor signalling, inducing metabolic rewiring and epigenetic remodelling. These changes establish long‐lasting trained immunity through the functional reprogramming of haematopoietic progenitors and innate immune cells, thereby
Desalegn Abebaw, Aytenew Atnaf, Bantayehu Addis Tegegne, Abebe Fenta, Bantegzie Selabat, Temesgen Baylie, Yonatan Kindie, Zigale Hibstu Teffera, Mekuriaw Belayneh, Mohammed Jemal, Adane Adugna   +10 more
wiley   +1 more source

Calcium/calmodulin-dependent protein kinase II binds to Raf-1 and modulates integrin-stimulated ERK activation

, 2003
Integrin activation generates different signalings in a cell type-dependent manner and stimulates cell proliferation through the Ras/Raf-1/Mek/Erk pathway.
A. L. Cavallo, K. U. Bayer, G. Rossi, ILLARIO, MADDALENA, T. D. Matola, M. Vitale, FENZI, GIANFRANCO   +6 more
core   +1 more source

Light signaling controls chloroplast pyruvate metabolism through the STF1/2–PKP1 module in soybean

Journal of Integrative Plant Biology, EarlyView.
In soybean, light‐responsive proteins switch on GmPKP1, which boosts chloroplast pyruvate production. This increases pigments, photosynthesis, seed oil, pod number, and yield, revealing a new way that light boosts crop productivity. ABSTRACT Light signaling coordinates plant development with metabolism, but the link between photoreceptors and ...
Faming Lin, Xiaoran Wang, Chenhao Zhao, Shaolong Yang, Jingnan Xu, Hongyi Su, Ruixiang Lei, Yilei Xu, Jike Xue, Ming Chang, Fanjiang Kong, Ran Wang   +11 more
wiley   +1 more source

Disruption of OsMAPKKK24 activation by the Xanthomonas oryzae effector XopY leads to compromised disease resistance in rice

Journal of Integrative Plant Biology, EarlyView.
The kinase OsRLCK55 phosphorylates OsMAPKKK24 to positively regulate rice resistance against Xanthomonas oryzae. To compromise this defense, the effector XopY targets OsMAPKKK24 and suppresses its autophosphorylation and the transphosphorylation mediated by OsRLCK55, ultimately leading to reduced disease resistance.
Lilan Chen, Yongming Chen, Wencai Xu, Xiaofang Wu, Shanshan Deng, Zhanchun Wang, Dingzhong Tang, Wei Wang   +7 more
wiley   +1 more source

Raf-1 protein kinase is required for growth of induced NIH/3T3 cells

, 1991
MANY growth factors regulate the cytoplasmic Raf-1 protein kinase1–10, consistent with its having a central role in transduction of growth signals. The kinase is ubiquitously expressed11 and can promote proliferation12, presumably in a manner dependent ...
Kolch, Walter, Rapp, Ulf R., Heidecker, Gisela, Lloyd, Patricia, Patricia Lloyd, Walter Kolch, Ulf R. Rapp, Gisela Heidecker   +7 more
core   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source