Results 121 to 130 of about 60,399 (263)

The MAPK Pathway-Based Drug Therapeutic Targets in Pituitary Adenomas

Frontiers in Endocrinology, 2019
Mitogen-activated protein kinases (MAPKs) include ERK, p38, and JNK MAPK subfamilies, which are crucial regulators of cellular physiology, cell pathology, and many diseases including cancers. For the MAPK signaling system in pituitary adenomas (PAs), the
Miaolong Lu, Miaolong Lu, Miaolong Lu, Ya Wang, Ya Wang, Ya Wang, Xianquan Zhan, Xianquan Zhan, Xianquan Zhan, Xianquan Zhan   +9 more
doaj   +1 more source

Raf/MEK/MAPK signaling stimulates the nuclear translocation and transactivating activity of FOXM1c [PDF]

, 2005
The forkhead box (FOX) transcription factor FOXM1 is ubiquitously expressed in proliferating cells. FOXM1 expression peaks at the G2/M phase of the cell cycle and its functional deficiency in mice leads to defects in mitosis.
Cheung, AMS, Leung, WY, Ma, RYM, Tong, THK, Tsang, ACC, Yao, KM   +5 more
core   +1 more source

Targeting GRP78 and the Proteostasis Network to Break the Therapeutic Ceiling in Neuroendocrine Prostate Cancer

iNew Medicine, EarlyView.
ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi, Md Rakibul Alam, Mithu Howlader, Mohammad Esfini Farahani, Lixiang Gu, Chun Li, Chripus Ngule, Kevin Fulp, Bolaji Owoyemi, Xinyi Wang, Samuel Nwadialo, Fatemeh Selani, Makumba Esoe, Obaleye Oluwafunminiyi, Zhiguo Li   +14 more
wiley   +1 more source

Impact of organic pollutants on phenotype and gene expression in human breast cancer cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Human exposure to industrial chemical compounds is widespread and, although often beneficial, prolonged contact may contribute to disease development, including cancer. While many studies have shown organic pollutants (OP) are cytotoxic, few have explored how long‐term exposure alters cell phenotype.
Camila Confortin, Heloisa Amancio, Jessica Zablocki da Luz, Aliciane de Almeida Roque, Tugstênio Lima de Souza, José Eduardo Vargas, Ciro Alberto de Oliveira Ribeiro, Francisco Filipak Neto   +7 more
wiley   +1 more source

Crosstalk between cAMP and MAP Kinase Signaling in the Regulation of Cell Proliferation

, 2002
Hormonal stimulation of cyclic adenosine monophosphate (cAMP) and the cAMP-dependent protein kinase PKA regulates cell growth by multiple mechanisms.
Altschuler, Ambrosini, Arai, Arslan, Barberis, Barnier, Blanco-Aparicio, Bos, Boucher, Burgering, Burgun, Busca, Caron, Cass, Chen, Chen, Chen, Cheng, Chiloeches, Ciullo, Cole, Cook, Cook, Cospedal, Crepieux, Crespo, Crespo, D'Angelo, Daaka, de Rooij, Deeble, Depoortere, Dhillon, Dremier, Dugan, Feliciello, Filippa, Gonzalez-Robayna, Gottesman, Graves, Greenberg, Grewal, Grewal, Howe, Hsueh, Hu, Iacovelli, Iida, Kahan, Kao, Katagiri, Kato, Kawasaki, Kievit, Kim, Kitayama, Kobierski, Kubicek, L'Allemain, LaBaer, Lee, Lindquist, MacNicol, Mason, McKenzie, Mei, Mikula, Mischak, Misra-Press, Morice, Mutoh, Myklebust, Naderi, Ohba, Osinski, Patterson, Pham, Piiper, Plevin, Qiu, Quilliam, Reedquist, Ribeiro-Neto, Richards, Rommel, Saxena, Schmitt, Schmitt, Schmitt, Scott, Sebzda, Seger, Sevetson, Sidovar, Swanson, Thoresen, Thorson, Tsukamoto, Tsygankova, Tsygankova, Vaillancourt, van Oirschot, Verheijen, Vogt Weisenhorn, von Lintig, Vossler, Wan, Wang, Wellbrock, Wojnowski, Wu, Yamaguchi, Yarwood, Yee, Yonehara, York, Young, Zanassi, Zhang, Zimmermann, Zou, Zwartkruis, Zwartkruis   +122 more
core   +1 more source

Co-Treatment with Panitumumab and Trastuzumab Augments Response to the MEK Inhibitor Trametinib in a Patient-Derived Xenograft Model of Pancreatic Cancer

Neoplasia: An International Journal for Oncology Research, 2014
Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations and epidermal growth factor receptor (EGFR) family signaling are drivers of tumorigenesis in pancreatic ductal adenocarcinoma (PDAC).
James M. Lindberg, Timothy E. Newhook, Sara J. Adair, Dustin M. Walters, Alison J. Kim, Edward B. Stelow, J. Thomas Parsons, Todd W. Bauer   +7 more
doaj   +1 more source

Biomarkers for the estimation of isoproterenol‐induced myocardial infarction: A review of key parameters

Journal of Intelligent Medicine, EarlyView.
Abstract The isoproterenol‐induced myocardial infarction model is a well‐established experimental approach for studying cardiac injury and testing potential protective treatments. By overstimulating beta‐adrenergic receptors, this model closely reproduces key features of human heart attacks, including oxidative damage, calcium imbalance, inflammatory ...
Bushra Imran, Tarique Mahmood, Farogh Ahsan, Shahzadi Bano, Vaseem Ahamad Ansari, Mohd Adnan   +5 more
wiley   +1 more source

Merlin Phosphorylation by p21-activated Kinase 2 and Effects of Phosphorylation on Merlin Localization [PDF]

, 2002
The Nf2 tumor suppressor gene product merlin is related to the membrane-cytoskeleton linker proteins of the band 4.1 superfamily, including ezrin, radixin, and moesin (ERMs). Merlin is regulated by phosphorylation in a Rac/cdc42-dependent fashion.
Eckman, Matthew S., Jacks, Tyler, Johnson, Kristen C., Kissil, Joseph L.   +3 more
core   +1 more source

Exome Sequencing Identifies Variants in MLH1 and ERBB2 as Potential Cancer‐Predisposing Factors in Familial Early‐Onset Colorectal Cancer

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Colorectal cancer (CRC) has raised considerable health concerns worldwide, with increasing incidence rates, specifically among younger populations. Despite remarkable progress in diagnosing and treating various diseases, the genetic basis of CRC remains only partially understood.
Behnaz Bagheri, Neda Mohsen‐Pour, Najmeh Salehi, Pardis Ketabi Moghadam, Adel Zeinalpour, Amir Sadeghi, Samira Kalayinia, Nayeralsadat Fatemi   +7 more
wiley   +1 more source

MiR-543 Promotes Proliferation and Epithelial-Mesenchymal Transition in Prostate Cancer via Targeting RKIP

Cellular Physiology and Biochemistry, 2017
Background/Aims: MicroRNAs (miRNAs, miRs) have emerged as important post-transcriptional regulators in various cancers. miR-543 has been reported to play critical roles in hepatocellular carcinoma and colorectal cancer, however, the role of miR-543 in ...
Yang Du, Xiu-heng Liu, Heng-cheng Zhu, Lei Wang, Jin-zhuo Ning, Cheng-cheng Xiao   +5 more
doaj   +1 more source