Results 61 to 70 of about 60,399 (263)

Targeting Oncogenic BRAF: Past, Present, and Future. [PDF]

, 2019
Identifying recurrent somatic genetic alterations of, and dependency on, the kinase BRAF has enabled a "precision medicine" paradigm to diagnose and treat BRAF-driven tumors.
Bivona, Trever G, Wu, Wei, Zaman, Aubhishek   +2 more
core   +1 more source

AB0140 The role of raf kinase inhibitory protein in rheumatoid arthritis [PDF]

Annals of the Rheumatic Diseases, 2018
Background Rheumatoid arthritis (RA) is an autoimmune inflammatory disease of the joints and is characterised by immune cell infiltration, synovial hyperplasia, and destruction of cartilage and underlying bone 1 . Raf kinase inhibitory protein (RKIP), an endogenous inhibitor of the extracellular signal-regulated kinase (ERK) pathway, has been ...
Y.-H. Cheon, Y.S. Suh, S.M. Yi, M. Kim, S.-I. Lee, H.S. Noh   +5 more
openaire   +1 more source

GRK2 Constitutively Governs Peripheral Delta Opioid Receptor Activity

Cell Reports, 2016
Opioids remain the standard for analgesic care; however, adverse effects of systemic treatments contraindicate long-term administration. While most clinical opioids target mu opioid receptors (MOR), those that target the delta class (DOR) also ...
Allison Doyle Brackley, Ruben Gomez, Armen N. Akopian, Michael A. Henry, Nathaniel A. Jeske   +4 more
doaj   +1 more source

Reduction of acetylcholine in the hippocampus of hippocampal cholinergic neurostimulating peptide precursor protein knockout mice

Scientific Reports, 2021
The cholinergic efferent network from the medial septal nucleus to the hippocampus plays an important role in learning and memory processes. This cholinergic projection can generate theta oscillations in the hippocampus to encode novel information ...
Yuko Kondo-Takuma, Masayuki Mizuno, Yo Tsuda, Yuta Madokoro, Kengo Suzuki, Toyohiro Sato, Hiroshi Takase, Yuto Uchida, Ken-ichi Adachi, Hideki Hida, Cesario V. Borlongan, Noriyuki Matsukawa   +11 more
doaj   +1 more source

RAGE Signaling in Skeletal Biology [PDF]

, 2019
PURPOSE OF REVIEW: The receptor for advanced glycation end products (RAGE) and several of its ligands have been implicated in the onset and progression of pathologies associated with aging, chronic inflammation, and cellular stress. In particular, the
Davis, Hannah M., Essex, Alyson L., Plotkin, Lilian I.   +2 more
core   +2 more sources

Development of Inflammatory Immune Response-Related Drugs Based on G Protein-Coupled Receptor Kinase 2

Cellular Physiology and Biochemistry, 2018
G protein-coupled receptor kinase 2 (GRK2), as a vital Ser/Thr kinase, is an important regulatory protein in the inflammatory immune response (IIR) by maintaining the balance between the function of inflammatory immune cells and non-conventional ...
Chenchen Han, Yifan Li, Yang Wang, Dongqian Cui, Tingting Luo, Yuwen Zhang, Yang Ma, Wei  Wei   +7 more
doaj   +1 more source

A new GTF2I-BRAF fusion mediating MAPK pathway activation in pilocytic astrocytoma. [PDF]

PLoS ONE, 2017
Pilocytic astrocytoma (PA) is the most common pediatric brain tumor. A recurrent feature of PA is deregulation of the mitogen activated protein kinase (MAPK) pathway most often through KIAA1549-BRAF fusion, but also by other BRAF- or RAF1-gene fusions ...
Tajana Tešan Tomić, Josefin Olausson, Annica Wilzén, Magnus Sabel, Katarina Truvé, Helene Sjögren, Sándor Dósa, Magnus Tisell, Birgitta Lannering, Fredrik Enlund, Tommy Martinsson, Pierre Åman, Frida Abel   +12 more
doaj   +1 more source

Molecular characterization of autophagic and apoptotic signaling induced by sorafenib in liver cancer cells [PDF]

, 2018
Sorafenib is the unique accepted molecular targeted drug for the treatment of patients in advanced stage of hepatocellular carcinoma. The current study evaluated cell signaling regulation of endoplasmic reticulum (ER) stress, c-Jun-N-terminal kinase (JNK)
Contreras Bernal, Laura, Cruz Díaz, Jesús de la, Gallego, Paloma, González, Raúl, Navarro Villarán, Elena, Ordóñez, Raquel, Rodríguez Arribas, M., Rodríguez Hernández, María A., Rosa, Ángel J. de la   +8 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Examining the role of insulin in the regulation of cardiovascular health [PDF]

, 2013
A substantial body of evidence has reported that insulin has direct actions on the cardiovascular system independent of its systemic effects on plasma glucose or lipids.
Salt, Ian P.
core   +1 more source