Results 71 to 80 of about 4,270,323 (214)

TWIN SISTER OF FT (TSF) Interacts with FRUCTOKINASE6 and Inhibits Its Kinase Activity in Arabidopsis

Frontiers in Plant Science, 2017
In flowering plants, the developmental switch to the reproductive phase is tightly regulated and involves the integration of internal and external signals. FLOWERING LOCUS T (FT) and TWIN SISTER OF FT (TSF) integrate signals from multiple pathways.
Suhyun Jin, Sun Young Kim, Ji Hoon Ahn
doaj   +1 more source

Enhanced peripheral blood mononuclear cell lipid metabolism drives poor immunotherapy response via ferroptotic stress‐induced T cell exhaustion in hepatocellular carcinoma

Interdisciplinary Medicine, EarlyView.
Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu, Zhouyu Ning, Yong Deng, Changjing Huang, Hui Li, Yun Sun, Zhiqiang Meng   +6 more
wiley   +1 more source

Raf kinase inhibitor protein is downregulated in hepatocellular carcinoma [PDF]

, 2006
The Ras/Raf/MEK/ERK signalling cascade is frequently deregulated in tumourigenic diseases and known to be involved in proliferation and transformation of cells.
Schuierer, Marion M., Weiss, Thomas S., Bataille, Frauke, Hellerbrand, Claus, Bosserhoff, Anja   +4 more
core   +1 more source

Nail Toxicities Associated With Anticancer Therapies in Children

JEADV Clinical Practice, EarlyView.
ABSTRACT Nail toxicities are a frequent yet often underrecognized component of dermatologic adverse events in children receiving anticancer therapies. Both conventional cytotoxic chemotherapy and newer targeted agents can affect the nail matrix, nail bed and periungual tissues, producing a broad spectrum of clinical manifestations that range from ...
Luca Rapparini, Michela Starace
wiley   +1 more source

Phosphorylation and regulation of Raf by Akt (protein kinase B).

, 1999
Activation of the protein kinase Raf can lead to opposing cellular responses such as proliferation, growth arrest, apoptosis, or differentiation. Akt (protein kinase B), a member of a different signaling pathway that also regulates these responses ...
Zimmermann S, Moelling K
core   +1 more source

Expression of Drug Targets in Patients Treated with Sorafenib, Carboplatin and Paclitaxel [PDF]

, 2013
Introduction: Sorafenib, a multitarget kinase inhibitor, targets members of the mitogen-activated protein kinase (MAPK) pathway and VEGFR kinases.
John M Kirkwood, Keith T Flaherty, Fengmin Zhao (139710), Kluger Harriet M., Wilson, M, Harriet M Kluger, Jilaveanu Lucia B., Rimm, DL, Lee, Sandra J., Kurt D'Andrea (442217), Rimm David L., Harriet M. Kluger (184091), Kluger, HM, D'Andrea, Kurt, Zhao, F, Kurt D'Andrea, Melissa Wilson (442218), Keith T. Flaherty (226339), Nathanson, KL, Kirkwood, John M., Sandra J. Lee (213144), Lee Sandra J., Fengmin Zhao, D'Andrea, K, Zhao, Fengmin, David L. Rimm (323315), Kirkwood, JM, Flaherty Keith T., Kirkwood John M., Sandra J Lee, Wilson Melissa, Katherine L Nathanson, Flaherty, Keith T., Jilaveanu, LB, John M. Kirkwood (141762), David L Rimm, Rimm, David L., Nathanson Katherine L., Zito, Christopher R., D'Andrea Kurt, Zito, CR, Lucia B Jilaveanu, Zhao Fengmin, Wilson, Melissa, Jilaveanu, Lucia B., Flaherty, KT, Lee, SJ, Katherine L. Nathanson (154077), Melissa Wilson, Smalley, Keiran, Lucia B. Jilaveanu (184077), Kluger, Harriet M., Christopher R. Zito (184074), Zito Christopher R., Christopher R Zito, Nathanson, Katherine L.   +55 more
core   +2 more sources

Genetic Mutations in Recurrent/Metastatic Papillary Thyroid Carcinoma

The Laryngoscope, EarlyView.
We investigated the mutational landscape and prognostic implications of recurrent/metastatic papillary thyroid carcinoma using nationwide C‐CAT data from 348 patients. CDKN2A, KMT2D, and concurrent TERT/BRAF mutations were independently associated with poorer overall survival, highlighting the potential prognostic value of comprehensive genomic ...
Hiromi Nagano, Satoshi Kiyama, Takayuki Kyutoku, Masaru Yamashita   +3 more
wiley   +1 more source

Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer

Medicinal Research Reviews, EarlyView.
ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek, Jernej Cingl, Urša Pečar Fonović, Tihomir Tomašič   +3 more
wiley   +1 more source

Downregulation of RKIP is associated with poor outcome and malignant progression in gliomas.

PLoS ONE, 2012
Malignant gliomas are highly infiltrative and invasive tumors, which precludes the few treatment options available. Therefore, there is an urgent need to elucidate the molecular mechanisms underlying gliomas aggressive phenotype and poor prognosis.
Olga Martinho, Sara Granja, Teresa Jaraquemada, Cláudia Caeiro, Vera Miranda-Gonçalves, Mrinalini Honavar, Paulo Costa, Margarida Damasceno, Marsha R Rosner, José M Lopes, Rui M Reis   +10 more
doaj   +1 more source

Activation of the MAP kinase pathway by the protein kinase raf

, 1992
Both MAP kinases and the protein kinase p74raf-1 are activated by many growth factors in a c-ras-dependent manner and by oncogenic p21ras. We were therefore interested in determining the relationship between MAP kinases and raf.
Gómez, Néstor, Nakielny, Sara, Leevers, Sally J., Cohen, Philip; id_orcid, Howe, Louise R., Marshall, Christopher J.   +5 more
core   +1 more source